Detailed information NTG0880322

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: RJW53_RS06620
• Genome accession: NZ_CP134488
• Coordinates: 1282259..1282930 (-)
• Length: 223 a.a.
• NCBI ID: WP_009909965.1
• Uniprot ID: A0A075SH40
• Organism: Streptococcus suis strain NLS50
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1277259..1287930

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
RJW53_RS06600 (RJW53_06600)	coaA	1277845..1278765 (+)	921	WP_002935283.1	type I pantothenate kinase	-
RJW53_RS06605 (RJW53_06605)	rpsT	1278824..1279072 (+)	249	WP_012027069.1	30S ribosomal protein S20	-
RJW53_RS06610 (RJW53_06610)	-	1279334..1280563 (-)	1230	WP_023369936.1	transglutaminase domain-containing protein	-
RJW53_RS06615 (RJW53_06615)	ciaH	1280887..1282266 (-)	1380	WP_024381361.1	cell wall metabolism sensor histidine kinase WalK	Regulator
RJW53_RS06620 (RJW53_06620)	ciaR	1282259..1282930 (-)	672	WP_009909965.1	response regulator transcription factor	Regulator
RJW53_RS06625 (RJW53_06625)	-	1283124..1283504 (-)	381	WP_023369940.1	hypothetical protein	-
RJW53_RS06630 (RJW53_06630)	phoU	1283670..1284326 (-)	657	WP_002937611.1	phosphate signaling complex protein PhoU	-
RJW53_RS06635 (RJW53_06635)	pstB	1284355..1285113 (-)	759	WP_074389058.1	phosphate ABC transporter ATP-binding protein PstB	-
RJW53_RS06640 (RJW53_06640)	pstB	1285125..1285928 (-)	804	WP_002940866.1	phosphate ABC transporter ATP-binding protein PstB	-
RJW53_RS06645 (RJW53_06645)	pstA	1285953..1286840 (-)	888	WP_002937616.1	phosphate ABC transporter permease PstA	-
RJW53_RS06650 (RJW53_06650)	pstC	1286830..1287747 (-)	918	WP_002937619.1	phosphate ABC transporter permease subunit PstC	-

Sequence

Protein

• Length: 223 a.a.
• Molecular weight: 25290.00 Da
• Isoelectric Point: 4.2183

>NTDB_id=880322 RJW53_RS06620 WP_009909965.1 1282259..1282930(-) (ciaR) [Streptococcus suis strain NLS50]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGEEGVYEAETGVYDLILLDLMLPEKDGFQVLKELREKGVTTPVLITTA
KESLEDKGHGFELGADDYLTKPFYLEELKMRIQALLKRAGKFNENTLTFGDVTVDLSTNMTMVNGEEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRIWGFDSDTTISVVEVYVSKIRKKLKGTTFGENLQTLRSVGYILKNA

Nucleotide

• Length: 672 bp

>NTDB_id=880322 RJW53_RS06620 WP_009909965.1 1282259..1282930(-) (ciaR) [Streptococcus suis strain NLS50]
ATGATTAAAATATTGTTAGTGGAAGATGATTTAAGTCTATCAAATTCTGTTTTCGATTTCTTAGATGATTTTGCGGATGT
TATGCAGGTTTTTGATGGTGAAGAGGGCGTTTATGAGGCGGAAACAGGCGTTTATGATTTGATTCTTTTGGATTTGATGT
TGCCTGAAAAAGATGGCTTCCAAGTCTTGAAAGAGTTACGTGAAAAGGGGGTTACGACACCAGTTCTGATTACAACAGCC
AAGGAAAGTCTAGAGGATAAAGGCCATGGTTTTGAATTGGGGGCTGATGACTATTTGACAAAACCGTTTTATTTAGAAGA
ATTGAAGATGCGAATTCAAGCTCTATTAAAACGAGCGGGTAAGTTTAATGAAAACACACTAACCTTTGGAGATGTGACAG
TTGACCTATCTACAAATATGACGATGGTAAATGGCGAAGAAGTTGAACTGCTAGGAAAAGAATTTGATCTACTAGTTTAT
TTCTTGCAAAATCAAAATGTTATTTTGCCAAAAACACAAATTTTTGACCGTATTTGGGGCTTTGACAGTGATACTACAAT
TTCAGTAGTAGAAGTATATGTTTCTAAAATTAGGAAAAAGTTGAAAGGAACGACCTTCGGGGAAAATCTTCAAACCCTGC
GTAGTGTCGGGTACATTCTAAAAAATGCCTAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

3D structure

• AlphaFold DB: A0A075SH40

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus mutans UA159	90.135	100	0.901
ciaR	Streptococcus pneumoniae Rx1	88.341	100	0.883
ciaR	Streptococcus pneumoniae D39	88.341	100	0.883
ciaR	Streptococcus pneumoniae R6	88.341	100	0.883
ciaR	Streptococcus pneumoniae TIGR4	88.341	100	0.883
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.496	100	0.39
vicR	Streptococcus mutans UA159	35.47	100	0.372
covR	Streptococcus salivarius strain HSISS4	35.841	100	0.363