Detailed information    

insolico Bioinformatically predicted

Overview


Name   clpP   Type   Regulator
Locus tag   RJW56_RS07825 Genome accession   NZ_CP134472
Coordinates   1577740..1578330 (-) Length   196 a.a.
NCBI ID   WP_002937303.1    Uniprot ID   A0A0K2E545
Organism   Streptococcus suis strain 1522228     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Related MGE


Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 1525724..1578330 1577740..1578330 within 0


Gene organization within MGE regions


Location: 1525724..1578330
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  RJW56_RS07445 (RJW56_07445) - 1525724..1526668 (-) 945 WP_024395069.1 bifunctional oligoribonuclease/PAP phosphatase NrnA -
  RJW56_RS07450 (RJW56_07450) - 1526763..1527224 (+) 462 WP_024395068.1 flavodoxin -
  RJW56_RS07455 (RJW56_07455) rpsN 1527365..1527634 (+) 270 WP_002940393.1 30S ribosomal protein S14 -
  RJW56_RS07460 (RJW56_07460) - 1527716..1527994 (+) 279 WP_024381604.1 chorismate mutase -
  RJW56_RS07465 (RJW56_07465) - 1527984..1529198 (+) 1215 WP_032533014.1 chloride channel protein -
  RJW56_RS07470 (RJW56_07470) - 1529651..1530028 (-) 378 WP_024394270.1 PBECR2 nuclease fold domain-containing protein -
  RJW56_RS07475 (RJW56_07475) - 1530093..1530830 (-) 738 WP_172051272.1 PlySs2 family phage lysin -
  RJW56_RS07480 (RJW56_07480) - 1530814..1531164 (-) 351 WP_002937841.1 phage holin -
  RJW56_RS07485 (RJW56_07485) - 1531167..1531466 (-) 300 WP_014636661.1 hypothetical protein -
  RJW56_RS07490 (RJW56_07490) - 1531470..1531814 (-) 345 WP_002937844.1 hypothetical protein -
  RJW56_RS07495 (RJW56_07495) - 1531817..1532035 (-) 219 WP_002937846.1 hypothetical protein -
  RJW56_RS07500 (RJW56_07500) - 1532044..1537353 (-) 5310 WP_172051271.1 phage tail spike protein -
  RJW56_RS07505 (RJW56_07505) - 1537350..1538045 (-) 696 WP_002937853.1 adenylosuccinate synthetase -
  RJW56_RS07510 (RJW56_07510) - 1538045..1540627 (-) 2583 WP_024417667.1 hypothetical protein -
  RJW56_RS07515 (RJW56_07515) - 1540617..1541000 (-) 384 WP_002937861.1 DUF5361 domain-containing protein -
  RJW56_RS07520 (RJW56_07520) - 1540997..1541275 (-) 279 WP_002937863.1 hypothetical protein -
  RJW56_RS07525 (RJW56_07525) - 1541286..1541873 (-) 588 WP_002937867.1 hypothetical protein -
  RJW56_RS07530 (RJW56_07530) - 1541889..1542224 (-) 336 WP_002937874.1 hypothetical protein -
  RJW56_RS07535 (RJW56_07535) - 1542221..1542460 (-) 240 WP_002937877.1 hypothetical protein -
  RJW56_RS07540 (RJW56_07540) - 1542453..1542791 (-) 339 WP_002937879.1 hypothetical protein -
  RJW56_RS07545 (RJW56_07545) - 1542778..1543173 (-) 396 WP_002937880.1 phage Gp19/Gp15/Gp42 family protein -
  RJW56_RS07550 (RJW56_07550) - 1543177..1543401 (-) 225 WP_002937881.1 HeH/LEM domain-containing protein -
  RJW56_RS07555 (RJW56_07555) - 1543403..1544305 (-) 903 WP_002937882.1 phage major capsid protein -
  RJW56_RS07560 (RJW56_07560) - 1544320..1544790 (-) 471 WP_002937883.1 DUF4355 domain-containing protein -
  RJW56_RS07565 (RJW56_07565) - 1544873..1546288 (-) 1416 WP_002937884.1 terminase -
  RJW56_RS07570 (RJW56_07570) - 1546433..1546564 (-) 132 WP_002937886.1 hypothetical protein -
  RJW56_RS07575 (RJW56_07575) - 1546633..1546845 (-) 213 WP_002937901.1 hypothetical protein -
  RJW56_RS07580 (RJW56_07580) - 1546842..1547921 (-) 1080 WP_002937903.1 hypothetical protein -
  RJW56_RS07585 (RJW56_07585) - 1547914..1549179 (-) 1266 WP_002937907.1 phage portal protein -
  RJW56_RS07590 (RJW56_07590) - 1549176..1549538 (-) 363 WP_002937910.1 hypothetical protein -
  RJW56_RS07595 (RJW56_07595) - 1549617..1549964 (-) 348 WP_002937914.1 HNH endonuclease -
  RJW56_RS07600 (RJW56_07600) - 1550061..1550495 (-) 435 WP_002937915.1 DUF1492 domain-containing protein -
  RJW56_RS07605 (RJW56_07605) - 1550572..1550823 (-) 252 WP_002937919.1 hypothetical protein -
  RJW56_RS07610 (RJW56_07610) - 1550896..1551743 (+) 848 WP_141669245.1 IS630 family transposase -
  RJW56_RS07615 (RJW56_07615) - 1551736..1552002 (-) 267 WP_172051244.1 hypothetical protein -
  RJW56_RS07620 (RJW56_07620) - 1552002..1552178 (-) 177 WP_002937925.1 hypothetical protein -
  RJW56_RS07625 (RJW56_07625) - 1552178..1552411 (-) 234 WP_002937935.1 hypothetical protein -
  RJW56_RS07630 (RJW56_07630) - 1552427..1552729 (-) 303 WP_002937939.1 DUF1372 family protein -
  RJW56_RS07635 (RJW56_07635) - 1552739..1553257 (-) 519 WP_002937943.1 hypothetical protein -
  RJW56_RS07640 (RJW56_07640) - 1553254..1553586 (-) 333 WP_002937944.1 hypothetical protein -
  RJW56_RS07645 (RJW56_07645) - 1553899..1554273 (-) 375 WP_002937949.1 hypothetical protein -
  RJW56_RS07650 (RJW56_07650) ssb 1554301..1554762 (-) 462 WP_002937951.1 single-stranded DNA-binding protein Machinery gene
  RJW56_RS07655 (RJW56_07655) - 1554865..1555044 (-) 180 WP_002937955.1 hypothetical protein -
  RJW56_RS07660 (RJW56_07660) - 1555034..1555360 (-) 327 WP_002937956.1 hypothetical protein -
  RJW56_RS07665 (RJW56_07665) - 1555370..1555639 (-) 270 WP_002937957.1 hypothetical protein -
  RJW56_RS07670 (RJW56_07670) - 1555642..1556670 (-) 1029 WP_014636674.1 DUF1351 domain-containing protein -
  RJW56_RS07675 (RJW56_07675) bet 1556680..1557450 (-) 771 WP_014636675.1 phage recombination protein Bet -
  RJW56_RS07680 (RJW56_07680) - 1557447..1557626 (-) 180 WP_004195116.1 hypothetical protein -
  RJW56_RS07685 (RJW56_07685) - 1557626..1557754 (-) 129 WP_014636676.1 hypothetical protein -
  RJW56_RS07690 (RJW56_07690) - 1557765..1557908 (-) 144 WP_014636677.1 hypothetical protein -
  RJW56_RS07695 (RJW56_07695) - 1558167..1558532 (-) 366 WP_004194647.1 hypothetical protein -
  RJW56_RS07700 (RJW56_07700) - 1558585..1558809 (-) 225 WP_004194648.1 hypothetical protein -
  RJW56_RS07705 (RJW56_07705) - 1558790..1559047 (-) 258 WP_014636678.1 hypothetical protein -
  RJW56_RS07710 (RJW56_07710) - 1559402..1560112 (-) 711 WP_014636680.1 phage antirepressor KilAC domain-containing protein -
  RJW56_RS07715 (RJW56_07715) - 1560166..1560855 (+) 690 WP_014636681.1 DUF4145 domain-containing protein -
  RJW56_RS07720 (RJW56_07720) - 1560951..1561172 (-) 222 WP_004195135.1 hypothetical protein -
  RJW56_RS07725 (RJW56_07725) - 1561232..1561441 (-) 210 WP_024395040.1 transcriptional regulator -
  RJW56_RS07730 (RJW56_07730) - 1561448..1561639 (-) 192 WP_024390858.1 helix-turn-helix transcriptional regulator -
  RJW56_RS07735 (RJW56_07735) - 1561782..1562006 (+) 225 WP_024377139.1 DUF2188 domain-containing protein -
  RJW56_RS07740 (RJW56_07740) - 1562003..1562143 (-) 141 WP_125064532.1 hypothetical protein -
  RJW56_RS07745 (RJW56_07745) - 1562567..1562713 (-) 147 WP_153308637.1 hypothetical protein -
  RJW56_RS07750 (RJW56_07750) - 1562887..1563630 (+) 744 WP_172051243.1 XRE family transcriptional regulator -
  RJW56_RS07755 (RJW56_07755) - 1563699..1564535 (+) 837 WP_024395036.1 type II toxin-antitoxin system PemK/MazF family toxin -
  RJW56_RS07760 (RJW56_07760) - 1565180..1566268 (+) 1089 WP_125169320.1 tyrosine-type recombinase/integrase -
  RJW56_RS07770 (RJW56_07770) - 1566579..1568603 (-) 2025 WP_023370923.1 bifunctional UDP-sugar hydrolase/5'-nucleotidase -
  RJW56_RS07775 (RJW56_07775) sodA 1568865..1569470 (-) 606 WP_024381607.1 superoxide dismutase SodA -
  RJW56_RS07780 (RJW56_07780) holA 1569583..1570614 (-) 1032 WP_024381608.1 DNA polymerase III subunit delta -
  RJW56_RS07785 (RJW56_07785) - 1570764..1571354 (-) 591 WP_013730461.1 hypothetical protein -
  RJW56_RS07790 (RJW56_07790) - 1571462..1572217 (-) 756 WP_002937287.1 epoxyqueuosine reductase QueH -
  RJW56_RS07795 (RJW56_07795) - 1572524..1573234 (-) 711 WP_002937288.1 ABC transporter ATP-binding protein -
  RJW56_RS07800 (RJW56_07800) - 1573234..1573998 (-) 765 WP_002937291.1 ABC transporter ATP-binding protein -
  RJW56_RS07805 (RJW56_07805) - 1573998..1574945 (-) 948 WP_002937293.1 branched-chain amino acid ABC transporter permease -
  RJW56_RS07810 (RJW56_07810) - 1574948..1575835 (-) 888 WP_002937296.1 branched-chain amino acid ABC transporter permease -
  RJW56_RS07815 (RJW56_07815) - 1576041..1577210 (-) 1170 WP_002937297.1 ABC transporter substrate-binding protein -
  RJW56_RS07820 (RJW56_07820) - 1577341..1577613 (-) 273 WP_002937299.1 YlbG family protein -
  RJW56_RS07825 (RJW56_07825) clpP 1577740..1578330 (-) 591 WP_002937303.1 ATP-dependent Clp protease proteolytic subunit Regulator

Sequence


Protein


Download         Length: 196 a.a.        Molecular weight: 21494.74 Da        Isoelectric Point: 5.7110

>NTDB_id=880122 RJW56_RS07825 WP_002937303.1 1577740..1578330(-) (clpP) [Streptococcus suis strain 1522228]
MIPVVIEQTSRGERSYDIYSRLLKDRIIMLTGPVEDNMANSIIAQLLFLDAQDPTKDIYLYVNTPGGSVSAGLAIVDTMN
FIKADVQTIVMGTAASMGTIIASSGAKGKRFMLPNAEYMIHQPMGGTGGGTQQTDMAIAAEHLLKTRNKLEKILADNSGK
TVKQIHKDAERDYWMSAEETLAYGFIDQIMDNTKVK

Nucleotide


Download         Length: 591 bp        

>NTDB_id=880122 RJW56_RS07825 WP_002937303.1 1577740..1578330(-) (clpP) [Streptococcus suis strain 1522228]
ATGATTCCAGTAGTTATTGAACAAACTAGCCGTGGTGAGCGTTCTTATGATATTTACTCACGCCTTTTGAAAGACCGCAT
TATCATGTTGACAGGACCAGTTGAGGACAACATGGCAAACTCTATCATTGCACAATTGCTTTTCCTTGATGCCCAAGACC
CTACAAAGGATATTTACCTCTATGTTAATACGCCAGGAGGATCGGTGTCAGCAGGTCTTGCCATTGTAGACACGATGAAT
TTCATTAAAGCTGATGTTCAAACCATCGTTATGGGAACAGCTGCGAGCATGGGAACCATCATTGCATCAAGCGGTGCCAA
GGGCAAACGTTTCATGTTGCCAAATGCAGAGTACATGATTCACCAGCCAATGGGTGGAACTGGTGGTGGTACTCAGCAAA
CAGATATGGCTATTGCTGCAGAACACCTATTAAAAACACGTAATAAGCTAGAAAAAATCTTGGCAGACAACTCAGGTAAG
ACAGTCAAGCAAATCCACAAGGATGCAGAACGTGATTACTGGATGTCAGCTGAAGAAACCTTGGCTTATGGATTTATTGA
CCAGATTATGGACAATACAAAAGTCAAATAA

Domains


Predicted by InterproScan.

(11-192)


Secondary structure


Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure


Source ID Structure
  AlphaFold DB A0A0K2E545

Transmembrane helices


Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.



Visualization of predicted probability:


Similar proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpP Streptococcus pyogenes JRS4

92.347

100

0.923

  clpP Streptococcus pyogenes MGAS315

92.347

100

0.923

  clpP Streptococcus mutans UA159

90.306

100

0.903

  clpP Streptococcus pneumoniae R6

88.776

100

0.888

  clpP Streptococcus pneumoniae Rx1

88.776

100

0.888

  clpP Streptococcus pneumoniae D39

88.776

100

0.888

  clpP Streptococcus pneumoniae TIGR4

88.776

100

0.888

  clpP Streptococcus thermophilus LMG 18311

88.776

100

0.888

  clpP Streptococcus thermophilus LMD-9

88.776

100

0.888

  clpP Lactococcus lactis subsp. lactis strain DGCC12653

84.184

100

0.842

  clpP Lactococcus lactis subsp. cremoris KW2

83.673

100

0.837

  clpP Bacillus subtilis subsp. subtilis str. 168

58.163

100

0.582

  clpP Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819

58.549

98.469

0.577