Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   RIN70_RS04270 Genome accession   NZ_CP134147
Coordinates   832399..833079 (+) Length   226 a.a.
NCBI ID   WP_003003305.1    Uniprot ID   A0A6I3P8Y0
Organism   Streptococcus parasanguinis strain 30.8.10     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 827399..838079
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  RIN70_RS04250 (RIN70_04250) phoU 827601..828254 (+) 654 WP_003006603.1 phosphate signaling complex protein PhoU -
  RIN70_RS04255 (RIN70_04255) - 828385..830928 (+) 2544 WP_195623089.1 M1 family metallopeptidase -
  RIN70_RS04260 (RIN70_04260) - 830985..831518 (-) 534 WP_003006609.1 biotin transporter BioY -
  RIN70_RS04265 (RIN70_04265) - 831724..832263 (+) 540 WP_313790709.1 hypothetical protein -
  RIN70_RS04270 (RIN70_04270) ciaR 832399..833079 (+) 681 WP_003003305.1 response regulator transcription factor Regulator
  RIN70_RS04275 (RIN70_04275) ciaH 833063..834424 (+) 1362 WP_313790710.1 HAMP domain-containing sensor histidine kinase Regulator
  RIN70_RS04280 (RIN70_04280) - 834454..834834 (+) 381 WP_003006623.1 VOC family protein -
  RIN70_RS04285 (RIN70_04285) - 835093..836475 (+) 1383 WP_070666109.1 polysaccharide deacetylase family protein -
  RIN70_RS04290 (RIN70_04290) - 836518..837603 (-) 1086 WP_070589290.1 DEAD/DEAH box helicase -

Sequence

Protein


Download         Length: 226 a.a.        Molecular weight: 25768.49 Da        Isoelectric Point: 4.3321

>NTDB_id=878871 RIN70_RS04270 WP_003003305.1 832399..833079(+) (ciaR) [Streptococcus parasanguinis strain 30.8.10]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGIYDLILLDLMLPEKDGFHVLKELREKGVTTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKVNENTLNYGNLKVNLSTNSTYVDDKEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKIRKKLKGTDFVESLQTLRSVGYILKDANKD

Nucleotide


Download         Length: 681 bp        

>NTDB_id=878871 RIN70_RS04270 WP_003003305.1 832399..833079(+) (ciaR) [Streptococcus parasanguinis strain 30.8.10]
ATGATTAAAATTCTATTGGTCGAAGATGACCTTGGTTTATCAAATTCAGTATTTGATTTTTTAGATGATTTTGCGGATGT
CATGCAGGTCTTTGACGGAGAAGAAGGTCTTTACGAAGCAGAAAGCGGGATCTATGATTTGATTCTGCTGGATCTCATGC
TTCCTGAAAAAGACGGCTTCCATGTCTTGAAAGAATTGCGTGAAAAAGGCGTGACAACCCCTGTTTTGATCATGACAGCT
AAAGAAAGTCTGGATGACAAAGGGCACGGCTTTGAGCTAGGTGCAGACGATTACCTCACCAAGCCTTTCTATCTTGAAGA
GCTTAAGATGCGGATCCAAGCTCTCTTGAAGCGGTCAGGTAAGGTCAATGAAAACACCCTCAATTATGGCAATTTGAAGG
TCAATTTATCTACCAATTCGACTTACGTGGACGATAAGGAAGTAGAACTTCTTGGGAAGGAATTTGATCTCTTGGTCTAC
TTCCTTCAAAACCAAAATGTCATCCTTCCAAAAACACAGATCTTCGATCGTCTCTGGGGCTTTGACAGTGACACAACTAT
CTCAGTGGTTGAAGTCTATGTTTCAAAAATCCGTAAGAAATTAAAAGGTACTGATTTTGTTGAGAGCTTGCAAACATTGC
GTAGTGTGGGGTATATCTTAAAAGATGCTAACAAGGATTAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A6I3P8Y0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

90.625

99.115

0.898
  ciaR Streptococcus pneumoniae D39

90.625

99.115

0.898
  ciaR Streptococcus pneumoniae R6

90.625

99.115

0.898
  ciaR Streptococcus pneumoniae TIGR4

90.625

99.115

0.898
  ciaR Streptococcus mutans UA159

87.946

99.115

0.872
  covR Lactococcus lactis subsp. lactis strain DGCC12653

37.445

100

0.376
  vicR Streptococcus mutans UA159

36.052

100

0.372
  micA Streptococcus pneumoniae Cp1015

34.746

100

0.363