Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   RDV49_RS08505 Genome accession   NZ_CP133988
Coordinates   1764298..1764978 (-) Length   226 a.a.
NCBI ID   WP_037607818.1    Uniprot ID   A0A2I1TVC1
Organism   Streptococcus parasanguinis strain B-1756     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1759298..1769978
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  RDV49_RS08485 (RDV49_08485) - 1759922..1761007 (+) 1086 WP_003006630.1 DEAD/DEAH box helicase -
  RDV49_RS08490 (RDV49_08490) - 1761050..1762432 (-) 1383 WP_003006627.1 polysaccharide deacetylase family protein -
  RDV49_RS08495 (RDV49_08495) - 1762543..1762923 (-) 381 WP_003006623.1 VOC family protein -
  RDV49_RS08500 (RDV49_08500) ciaH 1762953..1764314 (-) 1362 WP_003006620.1 cell wall metabolism sensor histidine kinase WalK Regulator
  RDV49_RS08505 (RDV49_08505) ciaR 1764298..1764978 (-) 681 WP_037607818.1 response regulator transcription factor Regulator
  RDV49_RS08510 (RDV49_08510) - 1765114..1765653 (-) 540 WP_003006614.1 hypothetical protein -
  RDV49_RS08515 (RDV49_08515) - 1765860..1766393 (+) 534 WP_003006609.1 biotin transporter BioY -
  RDV49_RS08520 (RDV49_08520) - 1766450..1768993 (-) 2544 WP_037607815.1 M1 family metallopeptidase -
  RDV49_RS08525 (RDV49_08525) phoU 1769124..1769777 (-) 654 WP_003006603.1 phosphate signaling complex protein PhoU -

Sequence

Protein


Download         Length: 226 a.a.        Molecular weight: 25709.43 Da        Isoelectric Point: 4.3559

>NTDB_id=878172 RDV49_RS08505 WP_037607818.1 1764298..1764978(-) (ciaR) [Streptococcus parasanguinis strain B-1756]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGIYDLILLDLMLPEKDGFHVLKELREKGVTTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKVNENTLNYGNLKVNLSTNSTYVDGKEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKIRKKLKGTDFVESLQTLRSVGYILKDANQN

Nucleotide


Download         Length: 681 bp        

>NTDB_id=878172 RDV49_RS08505 WP_037607818.1 1764298..1764978(-) (ciaR) [Streptococcus parasanguinis strain B-1756]
ATGATTAAAATTCTATTGGTCGAAGATGACCTTGGTTTGTCAAATTCAGTATTTGATTTTTTAGATGATTTTGCGGATGT
CATGCAGGTCTTTGACGGAGAAGAAGGCCTTTACGAAGCAGAAAGCGGGATCTATGATTTGATTTTGCTGGACCTCATGC
TTCCTGAAAAAGACGGTTTCCATGTCTTGAAAGAATTGCGTGAAAAAGGCGTGACAACCCCTGTTTTGATCATGACAGCC
AAAGAAAGTCTGGATGACAAGGGACACGGATTTGAGCTAGGGGCAGACGATTACCTCACTAAGCCTTTCTACCTAGAAGA
GCTTAAGATGCGGATTCAAGCCCTCTTGAAGCGCTCAGGAAAGGTCAATGAAAACACCCTTAATTATGGCAATTTGAAGG
TCAACTTATCTACCAATTCGACTTATGTGGATGGGAAAGAAGTGGAACTTCTTGGGAAGGAATTTGATCTTCTGGTCTAC
TTCCTTCAAAACCAAAATGTCATCCTTCCAAAAACACAGATTTTCGATCGCCTTTGGGGCTTTGACAGTGATACGACCAT
CTCTGTTGTTGAGGTATATGTTTCAAAAATCCGTAAAAAATTAAAAGGTACCGATTTCGTTGAGAGCTTGCAAACATTGC
GCAGTGTGGGGTATATCTTAAAAGATGCTAACCAGAATTAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)

Response regulator receiver domain (Response_reg)

(4-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A2I1TVC1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

90.179

99.115

0.894
  ciaR Streptococcus pneumoniae D39

90.179

99.115

0.894
  ciaR Streptococcus pneumoniae R6

90.179

99.115

0.894
  ciaR Streptococcus pneumoniae TIGR4

90.179

99.115

0.894
  ciaR Streptococcus mutans UA159

88.393

99.115

0.876
  vicR Streptococcus mutans UA159

36.481

100

0.376
  covR Lactococcus lactis subsp. lactis strain DGCC12653

36.889

99.558

0.367
  covR Streptococcus salivarius strain HSISS4

36.123

100

0.363