Detailed information NTG0877737

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: RIM63_RS00285
• Genome accession: NZ_CP133952
• Coordinates: 48949..49863 (+)
• Length: 304 a.a.
• NCBI ID: WP_115251528.1
• Uniprot ID: A0A380KQA4
• Organism: Streptococcus equi subsp. zooepidemicus strain HT321
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 43949..54863

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
RIM63_RS00265 (RIM63_00265)	purE	44092..44580 (+)	489	WP_196819743.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
RIM63_RS00270 (RIM63_00270)	purK	44567..45640 (+)	1074	WP_317584259.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
RIM63_RS00275 (RIM63_00275)	-	45656..47122 (+)	1467	WP_317584261.1	hypothetical protein	-
RIM63_RS00280 (RIM63_00280)	purB	47358..48650 (+)	1293	WP_037582405.1	adenylosuccinate lyase	-
RIM63_RS00285 (RIM63_00285)	comR	48949..49863 (+)	915	WP_115251528.1	XRE family transcriptional regulator	Regulator
RIM63_RS10425	comS	49946..50044 (+)	99	WP_200831644.1	quorum-sensing system DWW-type pheromone	Regulator
RIM63_RS00290 (RIM63_00290)	ruvB	50078..51079 (+)	1002	WP_111677625.1	Holliday junction branch migration DNA helicase RuvB	-
RIM63_RS00295 (RIM63_00295)	-	51372..51830 (+)	459	WP_126436186.1	low molecular weight protein-tyrosine-phosphatase	-
RIM63_RS00300 (RIM63_00300)	-	51836..52237 (+)	402	WP_037582396.1	membrane protein	-
RIM63_RS00305 (RIM63_00305)	-	52234..54015 (+)	1782	WP_317584266.1	acyltransferase family protein	-

Sequence

Protein

• Length: 304 a.a.
• Molecular weight: 35865.36 Da
• Isoelectric Point: 4.4139

>NTDB_id=877737 RIM63_RS00285 WP_115251528.1 48949..49863(+) (comR) [Streptococcus equi subsp. zooepidemicus strain HT321]
MLDNFGEKVRDLRYQKKITREDLCGDESELSIRQLARIELGQSIPSLSKVIFIAKALDVSVGFLTDGEDLELPKRYKELK
YLILRTPTYMDDDKLKLREEQFDEIFEDYYDQLPEEEKLVVDCLQSIMDTLLTENINFGVGLLQEYFEQTKSKTQFREND
LILIELYLAYLDIVGMNGEYSDKGFYDSLLDILLNQFEHFELEELFIVNKIAIGISSLSIKNNKLEILEKVIVLSQKIIL
KTQDFNRMPILNLIEWKYALMKKKDVEMAEKCYDKACLFAQLTGDQYLEKKLREEWDKDIKQYQ

Nucleotide

• Length: 915 bp

>NTDB_id=877737 RIM63_RS00285 WP_115251528.1 48949..49863(+) (comR) [Streptococcus equi subsp. zooepidemicus strain HT321]
ATGTTAGACAATTTTGGTGAAAAGGTGAGAGACCTTCGGTATCAGAAAAAAATTACCAGAGAGGATTTATGTGGAGATGA
GTCAGAATTATCCATTCGTCAATTGGCACGAATAGAACTGGGCCAATCGATTCCCAGCCTATCAAAGGTGATTTTTATTG
CTAAGGCTTTGGACGTTAGTGTCGGCTTTTTGACAGACGGAGAGGATTTGGAGCTACCGAAGCGCTATAAGGAGCTTAAA
TATTTGATTTTAAGAACACCGACCTATATGGACGATGACAAATTAAAGCTACGTGAAGAGCAATTTGACGAAATTTTTGA
AGATTATTATGATCAGCTGCCAGAGGAAGAAAAGCTTGTGGTGGACTGCTTGCAGTCCATAATGGATACGTTATTAACTG
AGAATATCAATTTTGGAGTTGGGTTATTACAGGAATACTTTGAACAGACAAAAAGCAAGACTCAATTTAGAGAGAATGAC
CTTATTCTTATTGAGCTGTATTTAGCGTATCTGGATATTGTGGGAATGAATGGAGAGTATTCAGATAAAGGATTCTATGA
TTCTTTATTAGACATTTTGTTAAATCAGTTTGAACATTTTGAATTAGAGGAATTATTTATCGTCAATAAAATAGCTATAG
GGATTTCCTCGTTGAGCATCAAAAACAATAAGCTGGAGATTCTTGAGAAGGTTATTGTGCTTAGTCAAAAAATTATTCTC
AAGACTCAGGATTTTAATAGAATGCCTATCTTAAATTTGATAGAGTGGAAATACGCTTTAATGAAGAAAAAAGACGTAGA
AATGGCAGAAAAATGTTATGATAAGGCATGCCTGTTTGCTCAATTAACAGGAGATCAGTATTTAGAAAAGAAATTAAGAG
AAGAATGGGATAAAGATATAAAACAATATCAATAG

Domains

Predicted by InterproScan.

• Helix-turn-helix domain (HTH_19) (6-69)

• ComR tetratricopeptide (ComR_TPR) (73-296)

3D structure

• AlphaFold DB: A0A380KQA4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS8232	75.248	99.671	0.75
comR	Streptococcus pyogenes MGAS315	54.817	99.013	0.543
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	52.069	95.395	0.497
comR	Streptococcus mutans UA159	48.495	98.355	0.477
comR	Streptococcus suis P1/7	38.591	98.026	0.378
comR	Streptococcus suis 05ZYH33	38.644	97.039	0.375
comR	Streptococcus suis D9	37.037	97.697	0.362