Detailed information NTG0870527

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: RA106_RS01395
• Genome accession: NZ_CP132900
• Coordinates: 254718..255617 (+)
• Length: 299 a.a.
• NCBI ID: WP_014607953.1
• Uniprot ID: A0AAN1ZWJ0
• Organism: Streptococcus thermophilus strain CICC 20372
• Function: activate transcription of comX; activate transcription of comS (predicted from homology) Competence regulation

Genomic Context

Location: 249718..260617

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
RA106_RS01375 (RA106_01380)	trkA	250854..252203 (-)	1350	WP_024704181.1	Trk system potassium transporter TrkA	-
RA106_RS01380 (RA106_01385)	-	252463..253002 (+)	540	WP_370869438.1	tRNA (cytidine(34)-2'-O)-methyltransferase	-
RA106_RS01385 (RA106_01390)	-	253313..253870 (+)	558	WP_024704183.1	ECF transporter S component	-
RA106_RS01390 (RA106_01395)	-	253873..254523 (+)	651	WP_011225447.1	phosphatase PAP2 family protein	-
RA106_RS01395 (RA106_01400)	comR	254718..255617 (+)	900	WP_014607953.1	helix-turn-helix domain-containing protein	Regulator
RA106_RS01400 (RA106_01405)	-	255855..256286 (+)	432	Protein_236	cysteine peptidase family C39 domain-containing protein	-
RA106_RS01405 (RA106_01410)	-	256316..257032 (+)	717	Protein_237	ABC transporter transmembrane domain-containing protein	-
RA106_RS01410 (RA106_01415)	comA	257054..257263 (+)	210	WP_002946147.1	hypothetical protein	Regulator
RA106_RS01415 (RA106_01420)	-	257318..257886 (+)	569	Protein_239	ATP-binding cassette domain-containing protein	-
RA106_RS01420 (RA106_01425)	-	257994..258326 (+)	333	WP_024704184.1	DUF805 domain-containing protein	-
RA106_RS01425 (RA106_01430)	-	258472..258951 (-)	480	WP_224107489.1	DUF4153 domain-containing protein	-
RA106_RS01430 (RA106_01435)	-	259393..259764 (-)	372	WP_224107488.1	hypothetical protein	-

Sequence

Protein

• Length: 299 a.a.
• Molecular weight: 35289.70 Da
• Isoelectric Point: 5.0061

>NTDB_id=870527 RA106_RS01395 WP_014607953.1 254718..255617(+) (comR) [Streptococcus thermophilus strain CICC 20372]
MNIKDSIGLRIKTERERQQMSREVLCLDGAELTVRQLIRIEKGESLPSLDRLSYIAKRLGKSMTELLDQDNITIPDEYYE
MKNRLIKFPTYRNPDRIKSKLTLIEEVYEKFFDILPEEELLTLDILENILSFTSWEESPKVEEIYEDLFEQVKRKRKFST
NDLLVIDYYFFHLYGRKQYDKKLFERIIKRVLNQEIWTDDVYNIVLFNDLMAIAALKIFHNSFSDFLTVVDKALAVIENS
QLYSYKPSVFVLKAKYELLHKENKKEAAENYDKAIMFASVLEDSVLEESIKAGKLADGL

Nucleotide

• Length: 900 bp

>NTDB_id=870527 RA106_RS01395 WP_014607953.1 254718..255617(+) (comR) [Streptococcus thermophilus strain CICC 20372]
TTGAACATAAAAGACAGCATTGGACTAAGAATCAAAACTGAGCGTGAACGCCAACAGATGTCACGTGAAGTGCTATGTTT
AGATGGTGCGGAATTGACTGTTCGCCAGTTAATTCGTATTGAAAAGGGGGAGTCTCTCCCGTCTTTAGATAGATTATCGT
ATATTGCTAAACGTTTAGGAAAAAGTATGACAGAGTTATTGGATCAAGACAATATTACCATTCCTGACGAATATTATGAA
ATGAAGAATCGTTTGATTAAGTTTCCAACGTACAGAAACCCTGACAGAATAAAGTCTAAACTTACTTTGATTGAGGAAGT
CTATGAGAAATTTTTTGATATTCTTCCAGAAGAAGAATTATTAACTCTAGACATTCTCGAAAATATATTGAGTTTTACTA
GCTGGGAGGAGAGTCCAAAAGTTGAGGAGATATATGAAGACTTGTTTGAACAAGTCAAAAGGAAGAGGAAATTCTCAACT
AACGATTTATTAGTCATTGACTATTATTTCTTTCATCTTTATGGGAGAAAACAGTATGACAAAAAACTATTTGAAAGAAT
TATAAAGAGAGTATTAAATCAGGAAATTTGGACAGATGATGTTTACAATATTGTTTTATTTAATGATTTGATGGCTATTG
CTGCTTTAAAGATTTTTCACAATTCCTTCTCAGACTTCTTAACAGTTGTGGATAAAGCCTTAGCTGTCATAGAAAACTCA
CAATTATATAGCTACAAGCCTAGTGTTTTTGTACTTAAGGCTAAATATGAACTTCTGCATAAAGAAAACAAGAAAGAGGC
TGCAGAGAATTATGATAAGGCCATAATGTTTGCTTCCGTTTTGGAAGACTCGGTTTTAGAGGAAAGTATAAAGGCAGGAA
AATTGGCAGATGGTTTATAG

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (11-66)

• ComR tetratricopeptide (ComR_TPR) (75-292)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus thermophilus LMG 18311	99.666	100	0.997
comR	Streptococcus thermophilus LMD-9	98.997	100	0.99
comR	Streptococcus salivarius strain HSISS4	94.983	100	0.95
comR	Streptococcus salivarius SK126	94.314	100	0.943
comR/comR2	Streptococcus sobrinus strain NIDR 6715-7	42.14	100	0.421
comR/comR1	Streptococcus sobrinus strain NIDR 6715-7	41.806	100	0.418