Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE   Type   Machinery gene
Locus tag   Q7612_RS03140 Genome accession   NZ_CP131722
Coordinates   629568..630905 (+) Length   445 a.a.
NCBI ID   WP_126513466.1    Uniprot ID   -
Organism   Haemophilus influenzae strain 2018C09-260     
Function   type IV pilus biogenesis and function (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 624568..635905
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  Q7612_RS03115 (Q7612_03110) - 624633..627227 (-) 2595 WP_342123008.1 penicillin-binding protein 1A -
  Q7612_RS03120 (Q7612_03115) comA 627326..628123 (+) 798 WP_005649306.1 pilus assembly protein PilM Machinery gene
  Q7612_RS03125 (Q7612_03120) comB 628124..628630 (+) 507 WP_005649305.1 competence protein ComB Machinery gene
  Q7612_RS03130 (Q7612_03125) comC 628627..629148 (+) 522 WP_005649304.1 competence protein ComC Machinery gene
  Q7612_RS03135 (Q7612_03130) comD 629145..629558 (+) 414 WP_126513465.1 pilus assembly protein PilP Machinery gene
  Q7612_RS03140 (Q7612_03135) comE 629568..630905 (+) 1338 WP_126513466.1 type IV pilus secretin PilQ family protein Machinery gene
  Q7612_RS03145 (Q7612_03140) - 630918..631604 (+) 687 WP_126513467.1 ComF family protein -
  Q7612_RS03150 (Q7612_03145) nfuA 631680..632276 (+) 597 WP_005649300.1 Fe-S biogenesis protein NfuA -
  Q7612_RS03155 (Q7612_03150) nudC 632343..633137 (+) 795 WP_005666520.1 NAD(+) diphosphatase -
  Q7612_RS03160 (Q7612_03155) - 633173..633763 (+) 591 WP_005649296.1 YjaG family protein -
  Q7612_RS03165 (Q7612_03160) - 633903..634175 (+) 273 WP_005630954.1 HU family DNA-binding protein -

Sequence

Protein


Download         Length: 445 a.a.        Molecular weight: 49124.40 Da        Isoelectric Point: 7.7999

>NTDB_id=864754 Q7612_RS03140 WP_126513466.1 629568..630905(+) (comE) [Haemophilus influenzae strain 2018C09-260]
MKKYLFKCGCFLVCFCLPLIVFANPKTDNERFFIRLSQAPLAQTLEQLAFQQDVNLVMGERLEGNISLKLNNIDMPRLLK
IIAKSKHLTLNKDDGVYYLNGSQSGKGQVAGNLTTNEPHLVSHTVKLHFAKASELMKSLTTGSGSLLSPDGSITFDDRSN
LLVIQDEPRSVQNIKKLIAEMDKPIEQIAIEARIVTITDESLKELGVRWGIFNPTENARRVAGSLTGNSFENIADNLNVN
FATTTTPAGSIALQVAKINGRLLDLELSALERENNVEIIASPRLLTTNKKSASIKQGTEIPYIVSNTRNDTQSVEFREAV
LGLEVTPHISKDNNILLDLLVSQNSPGSRVAYGQNEVVSIDKQEINTQVFAKDGETIVLGGVFHDTITKSEDKVPLLGDI
PVIKRLFSKESERHQKRELVIFVTPHILKAGETLEALKQKSAGKK

Nucleotide


Download         Length: 1338 bp        

>NTDB_id=864754 Q7612_RS03140 WP_126513466.1 629568..630905(+) (comE) [Haemophilus influenzae strain 2018C09-260]
ATGAAGAAATATCTTTTTAAGTGCGGTTGTTTTTTAGTGTGTTTTTGTTTGCCATTAATCGTCTTTGCTAATCCTAAAAC
AGATAACGAACGTTTTTTTATTCGTTTATCGCAAGCACCTTTAGCTCAAACACTGGAGCAATTAGCTTTTCAACAAGATG
TGAATTTAGTGATGGGTGAGAGGTTAGAAGGCAATATTTCTTTGAAATTAAACAATATTGATATGCCACGTTTGCTAAAA
ATAATCGCAAAAAGTAAGCATCTTACTTTGAATAAAGATGATGGGGTTTATTATTTAAACGGCAGTCAATCTGGCAAAGG
TCAAGTTGCAGGAAATCTTACGACAAATGAACCGCACTTAGTCAGCCACACGGTAAAACTCCATTTTGCTAAAGCCTCTG
AATTAATGAAATCCTTAACAACAGGAAGTGGATCTTTGCTTTCTCCCGATGGGAGCATTACCTTTGATGATCGCAGTAAT
TTGCTGGTTATTCAGGATGAACCTCGTTCTGTGCAAAATATCAAAAAACTAATTGCTGAAATGGATAAGCCTATTGAGCA
GATCGCTATTGAAGCGCGAATTGTGACAATTACGGATGAGAGTTTGAAAGAACTTGGCGTTCGGTGGGGGATTTTTAATC
CAACTGAAAATGCAAGACGAGTTGCGGGCAGCCTTACAGGCAATAGCTTTGAAAATATTGCGGATAATCTTAATGTAAAT
TTTGCGACAACGACGACACCTGCTGGCTCTATAGCATTACAAGTCGCGAAAATTAATGGGCGATTGCTTGATTTAGAATT
GAGTGCGTTGGAGCGTGAAAATAATGTAGAAATTATTGCAAGTCCTCGCTTACTCACTACCAATAAGAAAAGTGCGAGCA
TTAAACAGGGGACAGAAATTCCTTACATCGTGAGTAATACTCGTAACGATACGCAATCTGTGGAATTTCGTGAGGCGGTG
CTTGGTTTGGAAGTGACGCCACATATTTCTAAAGATAACAATATCTTACTTGATTTATTGGTAAGTCAAAATTCCCCTGG
TTCTCGTGTCGCTTATGGACAAAATGAGGTGGTTTCTATTGATAAACAAGAAATTAATACTCAGGTTTTTGCCAAAGATG
GGGAAACCATTGTGCTTGGCGGCGTATTTCACGACACAATCACGAAAAGCGAAGATAAAGTGCCATTGCTTGGCGATATA
CCCGTTATTAAACGATTATTTAGCAAAGAAAGTGAACGACATCAAAAACGTGAGCTAGTGATTTTCGTTACGCCGCATAT
TTTAAAAGCGGGGGAAACGTTAGAGGCGTTGAAACAAAAAAGTGCGGGGAAAAAATAA

Domains

Predicted by InterproScan.

Bacterial type II and III secretion system protein (Secretin)

(269-429)

Bacterial type II/III secretion system short domain (Secretin_N)

(123-187)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE Haemophilus influenzae 86-028NP

98.427

100

0.984
  comE Haemophilus influenzae Rd KW20

97.303

100

0.973
  comE Glaesserella parasuis strain SC1401

52.113

95.73

0.499
  pilQ Vibrio campbellii strain DS40M4

42.959

94.157

0.404
  pilQ Vibrio cholerae O1 biovar El Tor strain E7946

42.233

92.584

0.391
  pilQ Vibrio cholerae strain A1552

42.233

92.584

0.391