NTDB

Overview

Name	comEA/celA/cilE	Type	Machinery gene
Locus tag	Q7622_RS06365	Genome accession	NZ_CP131711
Coordinates	1247100..1247750 (+)	Length	216 a.a.
NCBI ID	WP_000387328.1	Uniprot ID	A0A4N9N7Z7
Organism	Streptococcus pneumoniae strain 2014C08-275
Function	dsDNA binding to the cell surface (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1242100..1252750

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
Q7622_RS06335 (Q7622_06330)	-	1242583..1242798 (+)	216	WP_001232081.1	YozE family protein	-
Q7622_RS06340 (Q7622_06335)	-	1242884..1243852 (+)	969	WP_000658198.1	PhoH family protein	-
Q7622_RS06345 (Q7622_06340)	-	1244045..1244545 (+)	501	WP_000566986.1	GNAT family N-acetyltransferase	-
Q7622_RS06350 (Q7622_06345)	-	1244548..1244874 (+)	327	Protein_1255	TfoX/Sxy family protein	-
Q7622_RS06355 (Q7622_06350)	ald	1245175..1246286 (-)	1112	Protein_1256	alanine dehydrogenase	-
Q7622_RS06360 (Q7622_06355)	-	1246463..1247032 (+)	570	WP_000443775.1	GNAT family N-acetyltransferase	-
Q7622_RS06365 (Q7622_06360)	comEA/celA/cilE	1247100..1247750 (+)	651	WP_000387328.1	ComEA family DNA-binding protein	Machinery gene
Q7622_RS06370 (Q7622_06365)	comEC/celB	1247734..1249974 (+)	2241	WP_000942392.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
Q7622_RS06375 (Q7622_06370)	-	1250116..1250340 (+)	225	WP_000583432.1	hypothetical protein	-
Q7622_RS06380 (Q7622_06375)	-	1250373..1250960 (+)	588	WP_000939884.1	ABC transporter ATP-binding protein	-
Q7622_RS06385 (Q7622_06380)	-	1250964..1252145 (+)	1182	WP_000655951.1	membrane protein	-

Sequence

Protein

Download Length: 216 a.a. Molecular weight: 23230.59 Da Isoelectric Point: 5.0667

                                >NTDB_id=864194 Q7622_RS06365 WP_000387328.1 1247100..1247750(+) (comEA/celA/cilE) [Streptococcus pneumoniae strain 2014C08-275]

MEAIIEKIKEYKIIVICTGLGLLVGGFFLLKPAPQTPVKETNLQAEVAAVSKDLVSEEEVNKEEKEEPLEQDLITVDVKG

AVKSPGIYDLPVGSRVNDAVQKAGGLTEQADSKSLNLAQKVSDEALVYVPTKGEEAVSQQTGLGTASSISKEKKVNLNKA

SLEELKQVKGLGGKRAQDIIDHREANGKFKSVDELKKVSGIGGKTIEKLKDYVTVD

Nucleotide

Download Length: 651 bp

                                >NTDB_id=864194 Q7622_RS06365 WP_000387328.1 1247100..1247750(+) (comEA/celA/cilE) [Streptococcus pneumoniae strain 2014C08-275]

ATGGAAGCAATTATCGAGAAAATCAAAGAGTATAAAATCATCGTCATCTGTACTGGTCTGGGCTTGCTTGTAGGAGGATT

TTTCCTGCTAAAACCAGCTCCACAAACACCTGTCAAAGAGACGAATTTGCAGGCTGAAGTCGCAGCTGTTTCCAAGGATT

TGGTATCCGAAGAGGAAGTGAACAAGGAAGAAAAGGAAGAACCCCTTGAACAAGATCTAATCACAGTAGATGTCAAAGGT

GCTGTCAAATCGCCAGGGATTTATGACTTGCCTGTAGGTAGTCGAGTCAATGATGCTGTTCAGAAGGCTGGTGGCTTGAC

AGAGCAAGCAGACAGCAAGTCGCTCAATCTAGCTCAGAAAGTTAGTGATGAGGCTCTGGTTTACGTTCCTACTAAGGGAG

AAGAAGCAGTTAGCCAACAGACTGGTTTGGGGACAGCTTCTTCAATAAGCAAGGAAAAGAAGGTCAATCTCAACAAGGCC

AGTCTGGAAGAACTCAAGCAGGTCAAGGGACTGGGAGGAAAACGAGCTCAGGACATTATCGACCATCGTGAGGCAAATGG

CAAGTTCAAGTCAGTAGACGAGCTCAAGAAGGTCTCTGGCATTGGTGGCAAAACAATAGAAAAGCTTAAAGACTATGTTA

CAGTGGATTAA

Domains

Predicted by InterproScan.

SLBB domain (SLBB)

(76-126)

Helix-hairpin-helix motif (HHH_3)

(151-214)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	A0A4N9N7Z7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
comEA/celA/cilE	Streptococcus pneumoniae Rx1	99.537	100	0.995
comEA/celA/cilE	Streptococcus pneumoniae D39	99.537	100	0.995
comEA/celA/cilE	Streptococcus pneumoniae R6	99.537	100	0.995
comEA/celA/cilE	Streptococcus pneumoniae TIGR4	96.759	100	0.968
comEA/celA/cilE	Streptococcus mitis NCTC 12261	95.833	100	0.958
comEA/celA/cilE	Streptococcus mitis SK321	89.815	100	0.898
comEA	Lactococcus lactis subsp. cremoris KW2	43.172	100	0.454
comEA	Bacillus subtilis subsp. subtilis str. 168	41.579	87.963	0.366

Detailed information NTG0864194