Detailed information NTG0863790

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: Q7627_RS02600
• Genome accession: NZ_CP131706
• Coordinates: 504208..504945 (+)
• Length: 245 a.a.
• NCBI ID: WP_001219120.1
• Uniprot ID: Q9S1I6
• Organism: Streptococcus pneumoniae strain 2018N21-288
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 499208..509945

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
Q7627_RS02565 (Q7627_02560)	-	500138..500377 (-)	240	WP_001810235.1	hypothetical protein	-
Q7627_RS02570 (Q7627_02565)	-	500539..500826 (-)	288	WP_000777760.1	hypothetical protein	-
Q7627_RS02575 (Q7627_02570)	-	500836..501246 (-)	411	WP_001278300.1	HIT family protein	-
Q7627_RS02580 (Q7627_02575)	pptA	501314..502045 (+)	732	WP_000889925.1	ABC transporter ATP-binding protein	Regulator
Q7627_RS02585 (Q7627_02580)	-	502042..503091 (+)	1050	WP_000653767.1	ABC transporter permease	-
Q7627_RS02590 (Q7627_02585)	-	503259..503588 (-)	330	WP_000132572.1	hypothetical protein	-
Q7627_RS02595 (Q7627_02590)	-	503865..504203 (+)	339	WP_000682135.1	LytTR family DNA-binding domain-containing protein	-
Q7627_RS02600 (Q7627_02595)	comE/blpR	504208..504945 (+)	738	WP_001219120.1	LytTR family DNA-binding domain-containing protein	Regulator
Q7627_RS02605 (Q7627_02600)	-	504959..506299 (+)	1341	WP_001017638.1	sensor histidine kinase	-
Q7627_RS02610 (Q7627_02605)	blpC	506341..506496 (-)	156	WP_000358817.1	quorum-sensing system pheromone BlpC	-
Q7627_RS02615 (Q7627_02610)	-	506553..507914 (-)	1362	WP_001069091.1	bacteriocin secretion accessory protein	-
Q7627_RS02620 (Q7627_02615)	comA/nlmT	507925..509601 (-)	1677	WP_196299874.1	peptide cleavage/export ABC transporter	Regulator

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28754.98 Da
• Isoelectric Point: 6.5884

>NTDB_id=863790 Q7627_RS02600 WP_001219120.1 504208..504945(+) (comE/blpR) [Streptococcus pneumoniae strain 2018N21-288]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRAHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INKLH

Nucleotide

• Length: 738 bp

>NTDB_id=863790 Q7627_RS02600 WP_001219120.1 504208..504945(+) (comE/blpR) [Streptococcus pneumoniae strain 2018N21-288]
ATGAGAATATTTGTTTTAGAGGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCTGAAGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAAGAGATGAAGGGACTGGAAGTGGCTAGAAAGATTCGGGATCGGGAT
CCTTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCTTTTCGCTACCAAGTGTCTGCTTTGGA
CTACATTGATAAGGCCTTGTCAGCAGAGGAGTTTGAATCTCGGATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTTCAGTATCCTTTTAAAGAGGTTTACTAT
CTCGAAACGTCGCCCAGAGCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTTTAGAGGA
GGTTTTCAAGCAGGAGCCCCGTCTCTTGCAGTGCCACCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTGCTTTTCTTTCCCAATGGTGGAAGTTGTCTAATCGCCCGTTATAAGGTCAGGGAAGTGTCTGAGGCC
ATCAATAAATTACACTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

3D structure

• AlphaFold DB: Q9S1I6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	54.321	99.184	0.539
comE/comE1	Streptococcus equinus JB1	43.46	96.735	0.42
comE/comE2	Streptococcus equinus JB1	38.017	98.776	0.376
comE	Streptococcus infantis strain Atu-4	35.887	100	0.363