Detailed information NTG0840680

Bioinformatically predicted

Overview

• Name: clpP
• Type: Regulator
• Locus tag: VKP54_RS01895
• Genome accession: NZ_CP142356
• Coordinates: 350011..350601 (+)
• Length: 196 a.a.
• NCBI ID: WP_002985850.1
• Uniprot ID: A0A9X9QW05
• Organism: Streptococcus pyogenes strain CT95-157
• Function: degradation of ComX (predicted from homology) Competence regulation

Genomic Context

Location: 345011..355601

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
VKP54_RS01880 (VKP54_01880)	-	345823..347268 (-)	1446	WP_111711344.1	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L- lysine ligase	-
VKP54_RS01885 (VKP54_01885)	-	347356..348990 (+)	1635	WP_002990932.1	polysaccharide biosynthesis protein	-
VKP54_RS01890 (VKP54_01890)	upp	349158..349787 (+)	630	WP_002985854.1	uracil phosphoribosyltransferase	-
VKP54_RS01895 (VKP54_01895)	clpP	350011..350601 (+)	591	WP_002985850.1	ATP-dependent Clp protease proteolytic subunit	Regulator
VKP54_RS01900 (VKP54_01900)	-	351096..351371 (+)	276	WP_002985847.1	YlbG family protein	-
VKP54_RS01905 (VKP54_01905)	tmk	351620..352255 (+)	636	WP_014635306.1	dTMP kinase	-
VKP54_RS01910 (VKP54_01910)	-	352273..353148 (+)	876	WP_011528291.1	DNA polymerase III subunit delta'	-
VKP54_RS01915 (VKP54_01915)	-	353273..353407 (+)	135	WP_014635307.1	tpl protein	-
VKP54_RS01920 (VKP54_01920)	yabA	353811..354134 (+)	324	WP_002985838.1	DNA replication initiation control protein YabA	-
VKP54_RS01925 (VKP54_01925)	rsmI	354139..355002 (+)	864	WP_002990904.1	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	-
VKP54_RS01930 (VKP54_01930)	-	355029..355421 (+)	393	WP_002985833.1	DUF5684 domain-containing protein	-

Sequence

Protein

• Length: 196 a.a.
• Molecular weight: 21648.88 Da
• Isoelectric Point: 5.2834

>NTDB_id=840680 VKP54_RS01895 WP_002985850.1 350011..350601(+) (clpP) [Streptococcus pyogenes strain CT95-157]
MIPVVIEQTSRGERSYDIYSRLLKDRIIMLTGPVEDNMANSVIAQLLFLDAQDNTKDIYLYVNTPGGSVSAGLAIVDTMN
FIKADVQTIVMGMAASMGTVIASSGTKGKRFMLPNAEYMIHQPMGGTGGGTQQTDMAIAAEHLLKTRHRLEKILAQNAGK
TIKQIHKDAERDYWMSAEETLAYGFIDEIMENNELK

Nucleotide

• Length: 591 bp

>NTDB_id=840680 VKP54_RS01895 WP_002985850.1 350011..350601(+) (clpP) [Streptococcus pyogenes strain CT95-157]
ATGATTCCTGTTGTTATTGAACAAACTAGTCGTGGAGAACGTTCTTATGACATTTATTCACGTTTATTAAAAGACCGTAT
TATCATGTTAACAGGGCCTGTCGAAGACAACATGGCCAACTCTGTCATAGCGCAGCTCTTATTCCTTGACGCGCAAGACA
ACACGAAAGATATCTACCTATATGTCAACACACCAGGTGGCTCTGTCTCAGCAGGCTTGGCTATTGTCGATACCATGAAC
TTTATCAAGGCCGATGTGCAAACTATTGTCATGGGTATGGCAGCTTCTATGGGGACAGTCATTGCTTCATCAGGAACAAA
AGGCAAACGCTTTATGTTACCAAATGCAGAGTATATGATCCACCAGCCAATGGGTGGCACAGGCGGTGGCACGCAACAAA
CGGATATGGCTATCGCAGCAGAACATCTCTTAAAAACACGTCACCGTTTAGAAAAAATCTTAGCGCAAAATGCTGGAAAA
ACGATTAAACAAATCCATAAAGATGCTGAGCGTGATTATTGGATGAGTGCTGAAGAAACCTTGGCTTACGGTTTCATTGA
TGAAATCATGGAAAACAACGAACTAAAATAA

Domains

Predicted by InterProScan.

• Clp protease (CLP_protease) (11-192)

3D structure

• AlphaFold DB: A0A9X9QW05

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpP	Streptococcus pyogenes MGAS315	100	100	1
clpP	Streptococcus pyogenes JRS4	100	100	1
clpP	Streptococcus mutans UA159	90.816	100	0.908
clpP	Streptococcus pneumoniae Rx1	90.769	99.49	0.903
clpP	Streptococcus pneumoniae D39	90.769	99.49	0.903
clpP	Streptococcus pneumoniae R6	90.769	99.49	0.903
clpP	Streptococcus pneumoniae TIGR4	90.769	99.49	0.903
clpP	Streptococcus thermophilus LMG 18311	89.796	100	0.898
clpP	Streptococcus thermophilus LMD-9	89.796	100	0.898
clpP	Lactococcus lactis subsp. lactis strain DGCC12653	86.224	100	0.862
clpP	Lactococcus lactis subsp. cremoris KW2	85.714	100	0.857
clpP	Bacillus subtilis subsp. subtilis str. 168	57.143	100	0.571
clpP	Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819	56.995	98.469	0.561