Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   VKP53_RS04390 Genome accession   NZ_CP142354
Coordinates   865565..866239 (+) Length   224 a.a.
NCBI ID   WP_002984519.1    Uniprot ID   A0A0H2UUK3
Organism   Streptococcus pyogenes strain 6745-99     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 860565..871239
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  VKP53_RS04375 (VKP53_04375) pstB 860997..861755 (+) 759 WP_002993892.1 phosphate ABC transporter ATP-binding protein PstB -
  VKP53_RS04380 (VKP53_04380) phoU 861823..862476 (+) 654 WP_326675185.1 phosphate signaling complex protein PhoU -
  VKP53_RS04385 (VKP53_04385) - 862681..865218 (+) 2538 WP_326675187.1 M1 family metallopeptidase -
  VKP53_RS04390 (VKP53_04390) ciaR 865565..866239 (+) 675 WP_002984519.1 response regulator transcription factor Regulator
  VKP53_RS04395 (VKP53_04395) ciaH 866232..867542 (+) 1311 WP_326675189.1 HAMP domain-containing sensor histidine kinase Regulator
  VKP53_RS04400 (VKP53_04400) rpsT 867667..867915 (-) 249 WP_009881183.1 30S ribosomal protein S20 -
  VKP53_RS04405 (VKP53_04405) coaA 867969..868889 (-) 921 WP_010922353.1 type I pantothenate kinase -
  VKP53_RS04410 (VKP53_04410) - 869157..869750 (+) 594 WP_010922352.1 class I SAM-dependent methyltransferase -
  VKP53_RS04415 (VKP53_04415) - 870403..870792 (+) 390 WP_002984531.1 cytidine deaminase -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25703.91 Da        Isoelectric Point: 4.7287

>NTDB_id=840517 VKP53_RS04390 WP_002984519.1 865565..866239(+) (ciaR) [Streptococcus pyogenes strain 6745-99]
MIKILLVEDDLSLSNSIFDFLDDFADVMQVFDGDEGLYEAESGIYDLILLDLMLPEKNGFQVLKELREKDIKIPVLIMTA
KEGLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRTGKFADKNISFGNLVVDLARKEVKVEGKVVELLGKEFDLLVY
LLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYISKIRKKLKGTRFVNRLQTLRSVGYILKNNE

Nucleotide


Download         Length: 675 bp        

>NTDB_id=840517 VKP53_RS04390 WP_002984519.1 865565..866239(+) (ciaR) [Streptococcus pyogenes strain 6745-99]
ATGATAAAAATATTATTAGTAGAAGATGACTTGAGCTTATCAAATTCCATTTTTGATTTTTTAGATGATTTTGCAGACGT
CATGCAAGTTTTTGATGGCGATGAAGGTTTATACGAAGCAGAAAGTGGTATTTATGATTTGATTTTGTTAGACCTTATGT
TGCCGGAGAAAAATGGCTTTCAAGTCTTAAAAGAATTGCGAGAAAAAGATATTAAAATTCCTGTATTGATCATGACAGCT
AAAGAGGGTTTAGATGATAAAGGCCACGGATTTGAATTAGGTGCTGATGATTATCTGACAAAGCCGTTCTATTTAGAAGA
GTTAAAAATGCGAATTCAAGCACTGTTAAAAAGAACAGGGAAATTTGCAGATAAAAATATTAGTTTTGGCAATTTAGTGG
TTGACTTAGCTCGAAAAGAGGTGAAGGTTGAAGGGAAAGTAGTTGAATTACTTGGCAAAGAATTTGATTTGTTGGTGTAT
CTTTTGCAAAATCAAAACGTTATTTTACCAAAGACACAAATTTTTGATCGTTTATGGGGATTCGATAGTGATACTACGAT
TTCGGTTGTTGAAGTTTACATTTCTAAAATAAGGAAAAAATTAAAAGGTACCCGTTTTGTTAACAGGCTTCAAACTTTAA
GAAGCGTAGGGTATATTCTAAAAAACAATGAATAA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0H2UUK3

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus mutans UA159

85.135

99.107

0.844
  ciaR Streptococcus pneumoniae D39

84.685

99.107

0.839
  ciaR Streptococcus pneumoniae R6

84.685

99.107

0.839
  ciaR Streptococcus pneumoniae TIGR4

84.685

99.107

0.839
  ciaR Streptococcus pneumoniae Rx1

84.685

99.107

0.839
  covR Lactococcus lactis subsp. lactis strain DGCC12653

39.111

100

0.393
  vicR Streptococcus mutans UA159

35.897

100

0.375
  micA Streptococcus pneumoniae Cp1015

35.47

100

0.371
  covR Streptococcus salivarius strain HSISS4

36.283

100

0.366