Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE   Type   Machinery gene
Locus tag   Hhaem_RS01365 Genome accession   NZ_AP024093
Coordinates   277011..278348 (-) Length   445 a.a.
NCBI ID   WP_223893822.1    Uniprot ID   -
Organism   Haemophilus haemolyticus strain 2019-19     
Function   type IV pilus biogenesis and function (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 272011..283348
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  Hhaem_RS01335 (Hhaem_02670) - 272841..273614 (-) 774 WP_223893818.1 DeoR/GlpR family DNA-binding transcription regulator -
  Hhaem_RS01340 (Hhaem_02680) - 273742..274014 (-) 273 WP_005634530.1 HU family DNA-binding protein -
  Hhaem_RS01345 (Hhaem_02690) - 274152..274742 (-) 591 WP_105893546.1 YjaG family protein -
  Hhaem_RS01350 (Hhaem_02700) nudC 274778..275572 (-) 795 WP_223893819.1 NAD(+) diphosphatase -
  Hhaem_RS01355 (Hhaem_02710) nfuA 275640..276236 (-) 597 WP_223893820.1 Fe-S biogenesis protein NfuA -
  Hhaem_RS01360 (Hhaem_02720) - 276312..276998 (-) 687 WP_223894288.1 ComF family protein -
  Hhaem_RS01365 (Hhaem_02730) comE 277011..278348 (-) 1338 WP_223893822.1 type IV pilus secretin PilQ family protein Machinery gene
  Hhaem_RS01370 (Hhaem_02740) comD 278358..278771 (-) 414 WP_223893823.1 pilus assembly protein PilP Machinery gene
  Hhaem_RS01375 (Hhaem_02750) comC 278768..279289 (-) 522 WP_118845892.1 competence protein ComC Machinery gene
  Hhaem_RS01380 (Hhaem_02760) comB 279286..279792 (-) 507 WP_223893824.1 competence protein B Machinery gene
  Hhaem_RS01385 (Hhaem_02770) comA 279793..280590 (-) 798 WP_223893825.1 competence protein ComA Machinery gene
  Hhaem_RS01390 (Hhaem_02780) - 280689..283292 (+) 2604 WP_223893826.1 penicillin-binding protein 1A -

Sequence

Protein


Download         Length: 445 a.a.        Molecular weight: 48929.14 Da        Isoelectric Point: 6.9094

>NTDB_id=83422 Hhaem_RS01365 WP_223893822.1 277011..278348(-) (comE) [Haemophilus haemolyticus strain 2019-19]
MKKCLLKCGYFLVCFCLPLIVFANPKTDNERFFIRLSQAPLAQTLEQLAFQHDVNLVMDETLEGNISLKLDNIDMPRLLQ
IIAKSKKLTLNKDEGIYYLNGGQSGKGQVAGNLATNEPHLMSHTVKLHFAKASELMKSLTTGSGSLLSPAGSITFDDRSN
LLVIQDEPRSVQNIKKLIYEMDKPIEQIAIEARIVTITDESLKELGVRWGIFNPTENAGRVAGSLAGNGFENITDNLNVN
FATTTTPAGSIALQVAKINGRLLDLELSALERENNVEIIASPRLLTTNKKSASIKQGTEIPYVVSNTRNDTQSVEFREAV
LGLEVTPHISKDNNILLDLLVSQNSPGSRVAYGQNEVVSIDKQEINTQVFAKDGETIVLGGVFHDTITKSEDKVPVLGDI
PGIKRLFSKESERHQKRELVIFVTPHILKAGETLDALKQKSAGKK

Nucleotide


Download         Length: 1338 bp        

>NTDB_id=83422 Hhaem_RS01365 WP_223893822.1 277011..278348(-) (comE) [Haemophilus haemolyticus strain 2019-19]
ATGAAGAAATGTCTTTTAAAGTGCGGTTATTTTTTAGTGTGTTTTTGTTTGCCATTAATCGTTTTTGCTAATCCTAAAAC
AGATAACGAACGTTTTTTTATTCGTTTATCTCAAGCGCCTTTAGCCCAAACACTGGAGCAATTAGCTTTTCAACATGATG
TCAATTTAGTGATGGATGAGACGCTAGAAGGCAATATTTCGTTGAAATTAGATAATATTGATATGCCACGTTTGCTACAA
ATAATCGCTAAAAGTAAGAAGCTTACTTTGAATAAAGACGAGGGTATTTACTATCTGAATGGAGGGCAATCAGGCAAAGG
TCAAGTTGCAGGAAATCTTGCTACAAATGAACCGCACTTAATGAGTCATACGGTTAAACTCCATTTTGCTAAAGCCTCTG
AATTAATGAAGTCCTTAACGACAGGAAGTGGCTCTTTGCTTTCACCAGCTGGGAGCATTACCTTTGATGATCGCAGTAAT
TTGCTCGTGATTCAAGATGAACCTCGTTCTGTGCAGAATATCAAAAAACTAATTTATGAAATGGATAAACCTATTGAGCA
GATCGCTATTGAAGCGCGTATTGTGACAATTACGGATGAGAGTTTGAAAGAGCTTGGCGTTCGCTGGGGGATTTTTAATC
CAACGGAAAATGCGGGGCGTGTAGCAGGTAGCCTCGCAGGCAATGGCTTTGAAAATATTACGGATAATCTTAATGTGAAT
TTTGCGACAACGACGACACCTGCTGGCTCGATAGCATTACAGGTCGCGAAAATTAATGGTCGATTGCTTGATTTAGAATT
GAGCGCTTTGGAGCGTGAAAATAATGTGGAAATTATCGCAAGTCCTCGCTTACTCACTACCAATAAGAAAAGTGCGAGCA
TTAAACAGGGGACAGAAATTCCTTATGTTGTGAGTAATACTCGTAATGATACACAATCTGTCGAATTTCGCGAAGCGGTG
CTAGGTTTGGAAGTGACACCACATATTTCTAAAGATAACAATATTTTGCTTGATTTATTAGTGAGCCAAAACTCCCCAGG
TTCTCGTGTTGCTTATGGACAAAACGAGGTGGTTTCTATTGATAAGCAAGAAATTAATACTCAGGTTTTTGCTAAAGATG
GGGAAACCATTGTGCTTGGCGGTGTGTTCCACGATACGATCACGAAAAGCGAAGATAAAGTGCCAGTACTTGGCGATATA
CCTGGCATTAAACGATTGTTTAGTAAAGAAAGTGAACGACATCAAAAACGTGAACTAGTGATTTTCGTGACGCCGCATAT
TTTAAAAGCAGGAGAAACGTTAGATGCTCTGAAGCAAAAAAGTGCGGGTAAAAAATAA

Domains

Predicted by InterproScan.

Bacterial type II/III secretion system short domain (Secretin_N)

(123-187)

Bacterial type II and III secretion system protein (Secretin)

(269-429)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE Haemophilus influenzae Rd KW20

94.382

100

0.944
  comE Haemophilus influenzae 86-028NP

94.382

100

0.944
  comE Glaesserella parasuis strain SC1401

52.471

95.506

0.501
  pilQ Vibrio campbellii strain DS40M4

42.417

94.831

0.402
  pilQ Vibrio cholerae O1 biovar El Tor strain E7946

41.505

92.584

0.384
  pilQ Vibrio cholerae strain A1552

41.505

92.584

0.384

Multiple sequence alignment