Detailed information NTG0082898

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: H7677_RS04320
• Genome accession: NZ_AP023391
• Coordinates: 868875..869546 (+)
• Length: 223 a.a.
• NCBI ID: WP_009909965.1
• Uniprot ID: A0A075SH40
• Organism: Streptococcus suis strain DAT299
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 863875..874546

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H7677_RS04290 (DAT299_08020)	pstC	864058..864975 (+)	918	WP_002937619.1	phosphate ABC transporter permease subunit PstC	-
H7677_RS04295 (DAT299_08030)	pstA	864965..865852 (+)	888	WP_014635996.1	phosphate ABC transporter permease PstA	-
H7677_RS04300 (DAT299_08040)	pstB	865877..866680 (+)	804	WP_002940866.1	phosphate ABC transporter ATP-binding protein PstB	-
H7677_RS04305 (DAT299_08050)	pstB	866692..867450 (+)	759	WP_002937614.1	phosphate ABC transporter ATP-binding protein PstB	-
H7677_RS04310 (DAT299_08060)	phoU	867479..868135 (+)	657	WP_002937611.1	phosphate signaling complex protein PhoU	-
H7677_RS04315 (DAT299_08070)	-	868301..868681 (+)	381	WP_184494264.1	hypothetical protein	-
H7677_RS04320 (DAT299_08080)	ciaR	868875..869546 (+)	672	WP_009909965.1	response regulator transcription factor	Regulator
H7677_RS04325 (DAT299_08090)	ciaH	869539..870918 (+)	1380	WP_024381361.1	sensor histidine kinase	Regulator
H7677_RS04330 (DAT299_08100)	-	871242..872471 (+)	1230	WP_002935288.1	transglutaminase domain-containing protein	-
H7677_RS04335 (DAT299_08110)	rpsT	872734..872982 (-)	249	WP_012027069.1	30S ribosomal protein S20	-
H7677_RS04340 (DAT299_08120)	coaA	873041..873961 (-)	921	WP_002935283.1	type I pantothenate kinase	-

Sequence

Protein

• Length: 223 a.a.
• Molecular weight: 25290.00 Da
• Isoelectric Point: 4.2183

>NTDB_id=82898 H7677_RS04320 WP_009909965.1 868875..869546(+) (ciaR) [Streptococcus suis strain DAT299]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGEEGVYEAETGVYDLILLDLMLPEKDGFQVLKELREKGVTTPVLITTA
KESLEDKGHGFELGADDYLTKPFYLEELKMRIQALLKRAGKFNENTLTFGDVTVDLSTNMTMVNGEEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRIWGFDSDTTISVVEVYVSKIRKKLKGTTFGENLQTLRSVGYILKNA

Nucleotide

• Length: 672 bp

>NTDB_id=82898 H7677_RS04320 WP_009909965.1 868875..869546(+) (ciaR) [Streptococcus suis strain DAT299]
ATGATTAAAATATTGTTAGTGGAAGATGATTTAAGTCTATCAAATTCTGTTTTCGATTTCTTAGATGATTTTGCGGATGT
TATGCAGGTTTTTGATGGTGAAGAGGGCGTTTATGAGGCGGAAACAGGCGTTTATGATTTGATTCTTTTGGATTTGATGT
TGCCTGAAAAAGATGGCTTCCAAGTCTTGAAAGAGTTACGTGAAAAGGGGGTTACGACACCAGTTCTGATTACAACAGCC
AAGGAAAGTCTAGAGGATAAAGGTCATGGTTTTGAATTGGGGGCTGATGACTATTTGACAAAACCGTTTTATTTAGAAGA
ATTGAAGATGCGAATTCAAGCTCTATTAAAACGAGCGGGTAAGTTTAATGAAAACACACTAACCTTTGGAGATGTGACAG
TTGACCTATCTACAAATATGACGATGGTAAATGGCGAAGAAGTTGAACTGCTAGGAAAAGAATTTGATTTACTAGTTTAT
TTCTTGCAAAATCAAAATGTTATTTTGCCAAAAACACAAATTTTTGACCGTATTTGGGGCTTTGACAGTGATACTACAAT
TTCAGTAGTAGAAGTATATGTTTCTAAAATTAGGAAAAAGTTGAAAGGAACGACCTTCGGGGAAAATCTTCAAACCCTGC
GTAGTGTCGGGTACATTCTAAAAAATGCCTAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

3D structure

• AlphaFold DB: A0A075SH40

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus mutans UA159	90.135	100	0.901
ciaR	Streptococcus pneumoniae Rx1	88.341	100	0.883
ciaR	Streptococcus pneumoniae D39	88.341	100	0.883
ciaR	Streptococcus pneumoniae R6	88.341	100	0.883
ciaR	Streptococcus pneumoniae TIGR4	88.341	100	0.883
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.496	100	0.39
vicR	Streptococcus mutans UA159	35.47	100	0.372
covR	Streptococcus salivarius strain HSISS4	35.841	100	0.363