Detailed information    

insolico Bioinformatically predicted

Overview

Name   vicR   Type   Regulator
Locus tag   H7675_RS06870 Genome accession   NZ_AP023389
Coordinates   1376997..1377707 (-) Length   236 a.a.
NCBI ID   WP_002985645.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain KUN-0012590     
Function   repress comCDE expression; repress comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1371997..1382707
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H7675_RS06855 (KUN2590_13030) rnc 1373715..1374407 (-) 693 WP_002985639.1 ribonuclease III -
  H7675_RS06860 (KUN2590_13040) vicX 1374839..1375648 (-) 810 WP_184004609.1 MBL fold metallo-hydrolase Regulator
  H7675_RS06865 (KUN2590_13050) vicK 1375652..1377004 (-) 1353 WP_002990673.1 cell wall metabolism sensor histidine kinase VicK Regulator
  H7675_RS06870 (KUN2590_13060) vicR 1376997..1377707 (-) 711 WP_002985645.1 response regulator YycF Regulator
  H7675_RS06875 (KUN2590_13070) - 1377869..1378903 (-) 1035 WP_011284595.1 DUF3114 domain-containing protein -
  H7675_RS06880 (KUN2590_13080) - 1378959..1380206 (-) 1248 WP_023612155.1 AMP-binding protein -
  H7675_RS06885 (KUN2590_13090) - 1380163..1381311 (-) 1149 WP_031488431.1 acetyl-CoA C-acyltransferase -
  H7675_RS06890 (KUN2590_13100) - 1381706..1381855 (-) 150 WP_002990686.1 hypothetical protein -

Sequence

Protein


Download         Length: 236 a.a.        Molecular weight: 27083.99 Da        Isoelectric Point: 4.9038

>NTDB_id=82800 H7675_RS06870 WP_002985645.1 1376997..1377707(-) (vicR) [Streptococcus pyogenes strain KUN-0012590]
MKKILIVDDEKPISDIIKFNLTKEGYDIVTAFDGREAVTIFEEEKPDLIILDLMLPELDGLEVAKEIRKTSHVPIIMLSA
KDSEFDKVIGLEIGADDYVTKPFSNRELLARVKAHLRRTETIETAVAEENASSGTQELTIGNLQILPDAFVAKKHGQEVE
LTHREFELLHHLANHMGQVMTREHLLEIVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMKSYD

Nucleotide


Download         Length: 711 bp        

>NTDB_id=82800 H7675_RS06870 WP_002985645.1 1376997..1377707(-) (vicR) [Streptococcus pyogenes strain KUN-0012590]
ATGAAAAAAATACTTATTGTGGATGATGAAAAACCGATTTCTGACATTATTAAGTTTAATTTGACAAAAGAAGGTTATGA
CATTGTTACAGCTTTTGATGGACGCGAAGCGGTAACAATTTTTGAAGAAGAAAAGCCAGATTTAATTATTCTTGATTTGA
TGCTCCCTGAGTTGGACGGTCTTGAAGTAGCCAAGGAAATTCGTAAAACCAGTCATGTCCCGATTATTATGTTGTCGGCT
AAAGATAGTGAGTTTGACAAGGTTATTGGACTTGAAATTGGGGCTGATGATTACGTGACCAAGCCCTTTTCTAATCGGGA
ATTGCTGGCACGTGTCAAGGCTCATCTGCGTCGTACCGAAACTATTGAAACGGCTGTTGCAGAAGAAAATGCTTCTTCAG
GTACACAGGAACTAACCATTGGTAATTTACAGATTTTACCAGATGCGTTTGTTGCTAAAAAACATGGTCAAGAGGTAGAG
TTGACCCATCGTGAATTTGAACTATTGCATCATCTAGCTAACCATATGGGTCAGGTGATGACACGAGAACACTTATTGGA
AATTGTTTGGGGATATGATTATTTTGGCGATGTGCGCACGGTTGATGTGACTGTTCGTCGTCTCCGTGAAAAAATTGAAG
ACACACCAAGTCGTCCTGAGTATATTTTAACAAGACGTGGTGTTGGGTACTACATGAAATCTTATGACTAG

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-113)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(156-231)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vicR Streptococcus mutans UA159

90.254

100

0.903
  micA Streptococcus pneumoniae Cp1015

79.06

99.153

0.784
  covR Streptococcus salivarius strain HSISS4

44.828

98.305

0.441
  covR Lactococcus lactis subsp. lactis strain DGCC12653

44.397

98.305

0.436
  scnR Streptococcus mutans UA159

36.91

98.729

0.364

Multiple sequence alignment