Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   P8R99_RS08185 Genome accession   NZ_CP121160
Coordinates   1533847..1534599 (+) Length   250 a.a.
NCBI ID   WP_278043271.1    Uniprot ID   -
Organism   Streptococcus agalactiae strain S5     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1528847..1539599
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  P8R99_RS08175 - 1530518..1532701 (+) 2184 WP_000795065.1 PTS transporter subunit IIBC -
  P8R99_RS08180 - 1532755..1533570 (+) 816 WP_001029869.1 endonuclease/exonuclease/phosphatase family protein -
  P8R99_RS08185 comE/blpR 1533847..1534599 (+) 753 WP_278043271.1 response regulator transcription factor Regulator
  P8R99_RS12020 - 1534668..1534966 (+) 299 Protein_1537 GHKL domain-containing protein -
  P8R99_RS08200 - 1535089..1535937 (+) 849 WP_000926589.1 ABC transporter ATP-binding protein -
  P8R99_RS08205 - 1535943..1537097 (+) 1155 WP_000623426.1 ABC transporter permease subunit -
  P8R99_RS08210 - 1537092..1537274 (-) 183 WP_001866975.1 hypothetical protein -
  P8R99_RS08215 - 1537326..1538360 (+) 1035 WP_000369169.1 acyltransferase family protein -
  P8R99_RS08220 - 1538608..1539033 (+) 426 WP_000823122.1 PTS mannose transporter subunit IIA -
  P8R99_RS08225 - 1539051..1539542 (+) 492 WP_000632641.1 PTS sugar transporter subunit IIB -

Sequence

Protein


Download         Length: 250 a.a.        Molecular weight: 29665.14 Da        Isoelectric Point: 6.3506

>NTDB_id=810679 P8R99_RS08185 WP_278043271.1 1533847..1534599(+) (comE/blpR) [Streptococcus agalactiae strain S5]
MNIFILEDDFVQQAHLEKIIKEIRVQYNLHFKTVETFAKPVQLLESIYEIGLHNLFFLDIEIKNDEQIGLEVAKQIRQVD
PYAQIVFVTTHSELMPLTFRYQVSALDYIDKGLSQEEFSQRIEEVLLYVDGICNKPLVENSFYFKSRYSQVQLPFNDLLY
IETSSRSHRVVLYTEKDRMEFTATLGDILKQEPRLFQCNRSFLVNPLNIFKVDRIDRLVYFQNGTTCLISRNKVRDIVSI
VDKYQKDRKR

Nucleotide


Download         Length: 753 bp        

>NTDB_id=810679 P8R99_RS08185 WP_278043271.1 1533847..1534599(+) (comE/blpR) [Streptococcus agalactiae strain S5]
GTGAATATTTTTATACTTGAGGATGATTTTGTTCAACAAGCCCATTTGGAAAAAATCATTAAAGAGATTAGAGTACAGTA
CAATCTGCATTTCAAAACAGTAGAAACGTTTGCTAAACCAGTTCAATTATTGGAGTCAATTTATGAAATAGGTTTGCATA
ATTTATTTTTCTTAGATATTGAAATAAAAAACGATGAGCAGATAGGCTTAGAGGTCGCAAAACAAATTAGACAAGTTGAT
CCTTATGCTCAGATTGTTTTTGTTACAACTCATTCAGAATTAATGCCTTTAACCTTTCGTTATCAGGTATCAGCTTTAGA
CTATATCGATAAAGGACTTTCACAGGAAGAGTTTAGCCAAAGGATTGAGGAAGTATTGTTGTACGTAGATGGCATTTGCA
ATAAGCCCTTAGTGGAAAATTCATTCTACTTTAAGTCGCGTTACAGCCAGGTACAATTACCTTTTAACGATCTTCTTTAT
ATAGAAACATCCTCAAGATCACATAGAGTTGTCCTTTATACTGAAAAAGATAGAATGGAATTCACAGCCACTTTGGGGGA
TATTTTAAAACAAGAACCTAGGCTCTTTCAATGTAATCGCTCTTTTTTAGTAAATCCCTTAAATATTTTTAAAGTGGATA
GGATAGATAGATTAGTTTACTTCCAAAATGGAACGACTTGTCTGATTTCACGCAATAAAGTGAGAGATATAGTATCTATA
GTGGATAAATATCAAAAGGATAGAAAAAGATGA

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(151-238)

Response regulator receiver domain (Response_reg)

(3-122)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

52.893

96.8

0.512
  comE/comE1 Streptococcus equinus JB1

40.741

97.2

0.396
  comE Streptococcus mitis NCTC 12261

37.6

100

0.376
  comE Streptococcus infantis strain Atu-4

37.45

100

0.376
  comE Streptococcus pneumoniae Rx1

37.097

99.2

0.368
  comE Streptococcus pneumoniae D39

37.097

99.2

0.368
  comE Streptococcus pneumoniae R6

37.097

99.2

0.368
  comE Streptococcus pneumoniae TIGR4

37.097

99.2

0.368
  comE Streptococcus mitis SK321

37.097

99.2

0.368