Detailed information NTG0798063

Bioinformatically predicted

Overview

• Name: vicR
• Type: Regulator
• Locus tag: PY824_RS08400
• Genome accession: NZ_CP119172
• Coordinates: 1610816..1611526 (-)
• Length: 236 a.a.
• NCBI ID: WP_014295010.1
• Uniprot ID: A0A1C3SQ68
• Organism: Streptococcus macedonicus strain SGM CIP105683
• Function: repress comCDE expression; repress comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1605816..1616526

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
PY824_RS08380 (PY824_08380)	rnc	1606051..1606737 (-)	687	WP_014295006.1	ribonuclease III	-
PY824_RS08385 (PY824_08385)	-	1607007..1608263 (+)	1257	WP_115265893.1	ISL3 family transposase	-
PY824_RS08390 (PY824_08390)	vicX	1608661..1609470 (-)	810	WP_115265894.1	MBL fold metallo-hydrolase	Regulator
PY824_RS08395 (PY824_08395)	vicK	1609471..1610823 (-)	1353	WP_014295009.1	cell wall metabolism sensor histidine kinase VicK	Regulator
PY824_RS08400 (PY824_08400)	vicR	1610816..1611526 (-)	711	WP_014295010.1	response regulator YycF	Regulator
PY824_RS08405 (PY824_08405)	-	1611831..1612595 (+)	765	WP_014295011.1	amino acid ABC transporter ATP-binding protein	-
PY824_RS08410 (PY824_08410)	-	1612606..1613418 (+)	813	WP_014295012.1	transporter substrate-binding domain-containing protein	-
PY824_RS08415 (PY824_08415)	-	1613435..1614139 (+)	705	WP_039671116.1	amino acid ABC transporter permease	-
PY824_RS08420 (PY824_08420)	-	1614151..1614798 (+)	648	WP_014295014.1	amino acid ABC transporter permease	-
PY824_RS08425 (PY824_08425)	-	1614890..1615498 (-)	609	WP_115265895.1	TVP38/TMEM64 family protein	-
PY824_RS08430 (PY824_08430)	-	1615746..1616048 (-)	303	WP_014295016.1	PepSY domain-containing protein	-

Sequence

Protein

• Length: 236 a.a.
• Molecular weight: 27116.91 Da
• Isoelectric Point: 4.6512

>NTDB_id=798063 PY824_RS08400 WP_014295010.1 1610816..1611526(-) (vicR) [Streptococcus macedonicus strain SGM CIP105683]
MKKILIVDDEKPISDIIKFNLTKEGYEAITAFDGREAITKFEEEDPDLIILDLMLPELDGLEVAKEVRKTSHIPIIILSA
KDSEFDKVIGLEIGADDYVTKPFSNRELLARVKAHLRRTENIETAVAEENASASNSEITIGDLKILPDAFVAQKRGEDIE
LTHREFELLHHLATHMGQVMTREYLLETVWGYDYFGDVRTVDVTIRRLREKIEDTPSRPEYILTRRGVGYYMKSYE

Nucleotide

• Length: 711 bp

>NTDB_id=798063 PY824_RS08400 WP_014295010.1 1610816..1611526(-) (vicR) [Streptococcus macedonicus strain SGM CIP105683]
ATGAAAAAAATTCTTATCGTTGATGATGAAAAACCAATTTCGGATATTATTAAATTTAATTTAACTAAAGAGGGTTATGA
AGCCATAACGGCTTTTGATGGTCGTGAAGCTATTACAAAGTTTGAGGAAGAAGACCCAGATTTGATTATCTTGGATTTGA
TGTTGCCAGAATTGGACGGACTTGAAGTGGCTAAAGAAGTTCGCAAGACAAGTCATATTCCAATCATTATATTGTCTGCT
AAGGATAGCGAGTTTGATAAAGTTATCGGACTTGAAATCGGTGCAGATGACTATGTAACCAAACCATTTTCAAATCGTGA
ATTGTTGGCGCGTGTTAAAGCGCACCTTCGTCGTACAGAAAATATTGAAACAGCAGTTGCTGAAGAAAATGCTTCTGCTT
CAAATTCAGAAATCACAATTGGTGACTTGAAAATCTTACCAGACGCCTTTGTGGCACAAAAACGTGGTGAAGATATCGAA
TTAACACACCGTGAGTTTGAATTGCTTCATCATTTGGCAACACATATGGGACAAGTCATGACCCGTGAATACCTTTTGGA
AACCGTTTGGGGCTATGATTATTTTGGTGATGTGCGTACGGTTGACGTAACCATTCGTCGTTTACGTGAAAAAATCGAAG
ACACACCAAGCCGTCCAGAATATATTTTGACACGTCGTGGTGTTGGGTACTACATGAAGTCATATGAATGA

Domains

Predicted by InterproScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (156-231)

• Response regulator receiver domain (Response_reg) (4-113)

3D structure

• AlphaFold DB: A0A1C3SQ68

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vicR	Streptococcus mutans UA159	89.407	100	0.894
micA	Streptococcus pneumoniae Cp1015	76.923	99.153	0.763
covR	Streptococcus salivarius strain HSISS4	46.983	98.305	0.462
covR	Lactococcus lactis subsp. lactis strain DGCC12653	45.259	98.305	0.445
scnR	Streptococcus mutans UA159	37.288	100	0.373