Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   PY824_RS05765 Genome accession   NZ_CP119172
Coordinates   1071687..1072361 (-) Length   224 a.a.
NCBI ID   WP_014294586.1    Uniprot ID   A0A380K9T7
Organism   Streptococcus macedonicus strain SGM CIP105683     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1066687..1077361
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  PY824_RS05740 (PY824_05740) deoC 1067114..1067776 (-) 663 WP_014294580.1 deoxyribose-phosphate aldolase -
  PY824_RS05745 (PY824_05745) - 1068267..1068860 (-) 594 WP_014294582.1 class I SAM-dependent methyltransferase -
  PY824_RS05750 (PY824_05750) coaA 1068974..1069894 (+) 921 WP_014294583.1 type I pantothenate kinase -
  PY824_RS05755 (PY824_05755) rpsT 1069969..1070220 (+) 252 WP_081498578.1 30S ribosomal protein S20 -
  PY824_RS05760 (PY824_05760) ciaH 1070357..1071697 (-) 1341 WP_039670832.1 cell wall metabolism sensor histidine kinase WalK Regulator
  PY824_RS05765 (PY824_05765) ciaR 1071687..1072361 (-) 675 WP_014294586.1 response regulator transcription factor Regulator
  PY824_RS05770 (PY824_05770) - 1072559..1075102 (-) 2544 WP_039670833.1 M1 family metallopeptidase -
  PY824_RS05775 (PY824_05775) - 1075403..1076659 (+) 1257 WP_039670834.1 ISL3 family transposase -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25525.27 Da        Isoelectric Point: 4.3477

>NTDB_id=798052 PY824_RS05765 WP_014294586.1 1071687..1072361(-) (ciaR) [Streptococcus macedonicus strain SGM CIP105683]
MIKILLVEDDLSLSNSIFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKDGFQVLKELREKGVSTPVLIMTA
KESLGDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKYNFNTLSYEELTVDTSTNTTIANGKEVELLGKEFDLLVY
FLQNQNVILPKSQIFDRIWGFDSDTTISVVEVYVSKIRKKLKDTTFAKNLQTLRSVGYILKNVE

Nucleotide


Download         Length: 675 bp        

>NTDB_id=798052 PY824_RS05765 WP_014294586.1 1071687..1072361(-) (ciaR) [Streptococcus macedonicus strain SGM CIP105683]
ATGATTAAGATATTATTAGTAGAGGATGATTTGAGTCTATCTAATTCCATTTTTGATTTTTTAGATGATTTTGCAGATGT
TATGCAGGTATTTGACGGCGAAGAAGGTTTGTACGAAGCTGAAAGTGGCGTATATGACCTTATTTTGCTTGACTTGATGT
TACCTGAAAAAGATGGTTTCCAAGTGCTTAAAGAGTTACGAGAAAAAGGTGTGTCAACACCAGTACTTATTATGACTGCC
AAAGAAAGTCTTGGTGATAAGGGACATGGTTTCGAGTTGGGAGCAGATGATTATCTTACTAAACCATTTTACCTTGAAGA
GCTAAAAATGCGTATTCAAGCTCTTTTAAAACGTTCGGGTAAATACAACTTCAATACCTTATCTTATGAAGAATTAACCG
TTGACACTTCTACCAATACAACAATAGCTAACGGTAAAGAAGTCGAGCTGCTTGGTAAAGAATTTGATTTGTTGGTTTAT
TTCTTACAAAATCAAAATGTTATTTTACCAAAATCACAAATTTTTGACCGTATTTGGGGCTTTGATAGTGATACAACGAT
TTCGGTTGTTGAAGTTTACGTTTCAAAAATTCGAAAAAAACTCAAAGACACCACCTTTGCCAAAAATCTTCAAACCCTAC
GGAGTGTAGGTTATATTCTGAAAAATGTTGAATAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)

Response regulator receiver domain (Response_reg)

(4-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A380K9T7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus mutans UA159

92.377

99.554

0.92
  ciaR Streptococcus pneumoniae Rx1

86.607

100

0.866
  ciaR Streptococcus pneumoniae D39

86.607

100

0.866
  ciaR Streptococcus pneumoniae R6

86.607

100

0.866
  ciaR Streptococcus pneumoniae TIGR4

86.607

100

0.866
  covR Lactococcus lactis subsp. lactis strain DGCC12653

38.938

100

0.393
  vicR Streptococcus mutans UA159

36.017

100

0.379
  micA Streptococcus pneumoniae Cp1015

35.193

100

0.366