Detailed information    

insolico Bioinformatically predicted

Overview

Name   comR   Type   Regulator
Locus tag   PY824_RS00875 Genome accession   NZ_CP119172
Coordinates   124442..125341 (+) Length   299 a.a.
NCBI ID   WP_039670354.1    Uniprot ID   A0A081JJT6
Organism   Streptococcus macedonicus strain SGM CIP105683     
Function   activate transcription of comX (predicted from homology)   
Competence regulation

Genomic Context

Location: 119442..130341
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  PY824_RS00835 (PY824_00835) comYF 119536..120003 (+) 468 WP_014293768.1 competence type IV pilus minor pilin ComGF Machinery gene
  PY824_RS00840 (PY824_00840) comYG 119975..120280 (+) 306 WP_014293769.1 competence type IV pilus minor pilin ComGG Machinery gene
  PY824_RS00845 (PY824_00845) comYH 120362..121318 (+) 957 WP_014293770.1 class I SAM-dependent methyltransferase Machinery gene
  PY824_RS00850 (PY824_00850) - 121371..122570 (+) 1200 WP_014293771.1 acetate kinase -
  PY824_RS00855 (PY824_00855) - 122732..122932 (+) 201 WP_012961332.1 helix-turn-helix transcriptional regulator -
  PY824_RS00860 (PY824_00860) - 122942..123151 (+) 210 WP_014293772.1 hypothetical protein -
  PY824_RS00865 (PY824_00865) - 123164..123616 (+) 453 WP_014293773.1 hypothetical protein -
  PY824_RS00870 (PY824_00870) - 123628..124263 (+) 636 WP_014293774.1 CPBP family intramembrane glutamic endopeptidase -
  PY824_RS00875 (PY824_00875) comR 124442..125341 (+) 900 WP_039670354.1 XRE family transcriptional regulator Regulator
  PY824_RS00880 (PY824_00880) purD 125815..127077 (+) 1263 WP_014293776.1 phosphoribosylamine--glycine ligase -
  PY824_RS00885 (PY824_00885) - 127067..127516 (+) 450 WP_115265954.1 DUF523 domain-containing protein -
  PY824_RS00890 (PY824_00890) purE 127516..128004 (+) 489 WP_014293778.1 5-(carboxyamino)imidazole ribonucleotide mutase -
  PY824_RS00895 (PY824_00895) purK 127991..129082 (+) 1092 WP_115265955.1 5-(carboxyamino)imidazole ribonucleotide synthase -
  PY824_RS00900 (PY824_00900) - 129102..129380 (+) 279 WP_014293780.1 hypothetical protein -

Sequence

Protein


Download         Length: 299 a.a.        Molecular weight: 34990.12 Da        Isoelectric Point: 4.9629

>NTDB_id=798027 PY824_RS00875 WP_039670354.1 124442..125341(+) (comR) [Streptococcus macedonicus strain SGM CIP105683]
MEKFGIKVRALREEKGISREEFCGDETELSVRQLARIEKGQSVPTLNKVGYIAKVLDVTIGELVDGKNLELPTRYKELKY
LLLRTPTYGDEKRLQRQTSYFDEIAERYYEVIPEEERLVIDCLQSKIDVHFSDDVNFGEGILNDYFDQVRRKKKFQINDL
ILIDLYFACLASAKSFEGIYSLDLYDELMECLLNQENLSPETSLILNNVLLNNVDLVLRFHRESFIKRIIIKSDTIMASI
HDFQRRPVLSLVEWKYYLQFKKDFLAAQKSYSNAILFANLIGDTYLKSKLVEEWNNDTT

Nucleotide


Download         Length: 900 bp        

>NTDB_id=798027 PY824_RS00875 WP_039670354.1 124442..125341(+) (comR) [Streptococcus macedonicus strain SGM CIP105683]
TTGGAAAAGTTTGGGATTAAAGTACGTGCATTAAGAGAGGAAAAAGGAATTTCACGTGAGGAATTTTGTGGCGATGAAAC
AGAATTGTCTGTACGGCAATTAGCTAGAATTGAAAAGGGACAATCCGTTCCAACTCTTAATAAAGTGGGATATATTGCAA
AGGTTTTGGACGTAACGATTGGTGAATTAGTTGATGGTAAAAATCTAGAGCTTCCTACTAGATACAAGGAGTTAAAGTAT
TTATTATTGCGAACACCGACTTATGGAGATGAGAAACGTCTTCAGAGACAAACTTCCTATTTTGACGAGATTGCAGAAAG
ATATTACGAAGTTATACCTGAAGAGGAACGTTTGGTTATTGATTGTTTACAATCAAAGATTGATGTTCATTTCAGTGATG
ATGTTAATTTTGGTGAGGGAATTTTAAATGACTATTTTGACCAGGTTAGACGAAAGAAAAAATTTCAAATCAATGATTTG
ATTTTAATAGATTTATATTTTGCTTGCCTTGCTTCTGCTAAATCGTTTGAGGGAATCTATAGCTTAGATTTATATGATGA
ATTAATGGAGTGTTTGCTGAATCAAGAAAATCTTTCGCCAGAAACTTCTTTGATTTTAAATAATGTTTTATTAAATAATG
TAGATTTGGTTTTACGATTCCATAGAGAATCATTTATAAAACGAATAATTATAAAAAGCGACACTATCATGGCAAGTATT
CATGATTTTCAAAGACGTCCAGTTTTAAGTTTAGTTGAGTGGAAATATTATTTACAATTTAAAAAAGATTTTTTAGCGGC
ACAAAAATCTTACTCCAATGCAATTTTATTTGCTAATTTAATTGGAGATACTTATTTGAAAAGTAAATTAGTAGAAGAAT
GGAATAATGATACAACATGA

Domains

Predicted by InterproScan.

Helix-turn-helix (HTH_3)

(8-63)

ComR tetratricopeptide (ComR_TPR)

(72-294)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A081JJT6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comR Streptococcus infantarius subsp. infantarius ATCC BAA-102

72.125

95.987

0.692
  comR Streptococcus mutans UA159

53.512

100

0.535
  comR Streptococcus pyogenes MGAS8232

49

100

0.492
  comR Streptococcus pyogenes MGAS315

47.987

99.666

0.478
  comR Streptococcus suis P1/7

39.933

99.666

0.398
  comR Streptococcus suis 05ZYH33

40.067

99.331

0.398
  comR Streptococcus suis D9

38.591

99.666

0.385