Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE   Type   Machinery gene
Locus tag   HIY_RS03430 Genome accession   NZ_AP022867
Coordinates   658078..659415 (+) Length   445 a.a.
NCBI ID   WP_005659796.1    Uniprot ID   -
Organism   Haemophilus influenzae strain 2018-Y40     
Function   type IV pilus biogenesis and function (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 653078..664415
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HIY_RS03405 (HIY_06530) - 653146..655740 (-) 2595 WP_005656471.1 penicillin-binding protein 1A -
  HIY_RS03410 (HIY_06540) comA 655836..656633 (+) 798 WP_005656469.1 pilus assembly protein PilM Machinery gene
  HIY_RS03415 (HIY_06550) comB 656634..657140 (+) 507 WP_005656467.1 competence protein ComB Machinery gene
  HIY_RS03420 (HIY_06560) comC 657137..657658 (+) 522 WP_005656465.1 competence protein ComC Machinery gene
  HIY_RS03425 (HIY_06570) comD 657655..658068 (+) 414 WP_005656464.1 pilus assembly protein PilP Machinery gene
  HIY_RS03430 (HIY_06580) comE 658078..659415 (+) 1338 WP_005659796.1 type IV pilus secretin PilQ family protein Machinery gene
  HIY_RS03435 (HIY_06590) - 659428..660114 (+) 687 WP_005656460.1 ComF family protein -
  HIY_RS03440 (HIY_06600) nfuA 660190..660786 (+) 597 WP_005656459.1 Fe-S biogenesis protein NfuA -
  HIY_RS03445 (HIY_06610) nudC 660853..661647 (+) 795 WP_005656457.1 NAD(+) diphosphatase -
  HIY_RS03450 (HIY_06620) - 661683..662273 (+) 591 WP_005656455.1 YjaG family protein -
  HIY_RS03455 (HIY_06630) - 662413..662685 (+) 273 WP_005630954.1 HU family DNA-binding protein -

Sequence

Protein


Download         Length: 445 a.a.        Molecular weight: 49108.40 Da        Isoelectric Point: 7.4794

>NTDB_id=79562 HIY_RS03430 WP_005659796.1 658078..659415(+) (comE) [Haemophilus influenzae strain 2018-Y40]
MKKYFLKCGCFLVFFCLPLIVFANPKTDNERFFIRLSQAPLAQTVEQLAFQQDVNLVIGDILESKISLKLNNIDMPRLLK
IIAKSKHLTLNKDDGIYYLNGSQSGKGEVAGNLTTNEPHLVSHTVKLHFAKASELMKSLTTGSGSLLSPDGSITFDDRSN
LLVIQDEPRSVQNIKKLIAEMDKPIEQIAIEARIVTITDESLKELGVRWGIFNPTENARRVAGSLAGNSFENIADNLNVN
FATTTTPAGSIALQVAKINGRLLDLELSALERENNVEIIASPRLLTTNKKSASIKQGTEIPYIVSNTRNDTQSVEFREAV
LGLEVTPHISKDNNILLDLLVSQNSPGSRVAYGQNEVVSIDKQEINTQVFAKDGETIVLGGVFHDTITKSEDKVPLLGDI
PVIKRLFSKESERHQKRELVIFVTPHILKAGETLEALKQKSAGKK

Nucleotide


Download         Length: 1338 bp        

>NTDB_id=79562 HIY_RS03430 WP_005659796.1 658078..659415(+) (comE) [Haemophilus influenzae strain 2018-Y40]
ATGAAGAAATATTTTTTAAAGTGCGGTTGTTTTTTAGTATTTTTTTGTTTGCCATTAATCGTTTTTGCTAATCCTAAAAC
AGATAACGAACGTTTTTTTATTCGTTTATCGCAAGCACCTTTAGCTCAAACAGTGGAGCAATTAGCTTTTCAACAAGATG
TGAATTTAGTGATTGGAGATATATTGGAAAGCAAGATCTCTTTGAAATTAAACAATATTGATATGCCACGTTTGCTAAAA
ATAATCGCAAAAAGTAAGCATCTTACTTTGAATAAAGATGATGGGATTTATTATTTAAACGGCAGTCAATCTGGCAAAGG
TGAAGTTGCAGGAAATCTTACGACAAATGAACCGCACTTAGTGAGTCACACGGTAAAACTCCATTTTGCTAAAGCCTCTG
AATTAATGAAATCTTTAACAACAGGAAGTGGCTCTTTGCTTTCTCCCGATGGGAGCATTACCTTTGATGATCGCAGTAAT
TTGCTGGTTATTCAGGATGAACCTCGTTCTGTGCAAAATATCAAAAAACTGATTGCTGAAATGGATAAGCCTATTGAACA
GATCGCTATTGAAGCGCGAATTGTGACAATTACGGATGAGAGTTTGAAAGAACTTGGCGTTCGGTGGGGGATTTTTAATC
CAACTGAAAATGCAAGACGAGTTGCGGGCAGCCTCGCAGGCAATAGCTTTGAAAATATTGCGGATAATCTTAATGTAAAT
TTTGCGACAACGACGACACCTGCTGGCTCTATAGCATTACAAGTCGCGAAAATTAATGGGCGATTGCTTGATTTAGAATT
GAGTGCGTTGGAGCGTGAAAATAATGTAGAAATTATTGCAAGTCCTCGCTTACTCACTACCAATAAGAAAAGTGCGAGCA
TTAAACAGGGGACAGAAATTCCTTACATCGTGAGCAATACTCGTAACGATACGCAATCTGTGGAATTTCGTGAGGCAGTA
CTTGGTTTGGAAGTGACGCCGCATATTTCTAAAGATAACAATATCTTACTTGATTTATTGGTAAGTCAAAATTCCCCTGG
TTCTCGTGTCGCTTATGGACAAAATGAGGTGGTTTCTATTGATAAGCAAGAAATTAATACTCAGGTTTTTGCCAAAGATG
GGGAAACCATTGTGCTTGGCGGCGTATTTCACGACACAATCACGAAAAGCGAAGATAAAGTGCCATTGCTTGGCGATATA
CCCGTTATTAAACGATTATTTAGCAAAGAAAGTGAACGACATCAAAAACGTGAGCTCGTGATTTTCGTGACGCCACATAT
TTTAAAAGCAGGAGAAACGTTAGAGGCGTTGAAACAAAAAAGTGCGGGCAAAAAATAA

Domains

Predicted by InterproScan.

Bacterial type II and III secretion system protein (Secretin)

(269-429)

Bacterial type II/III secretion system short domain (Secretin_N)

(123-187)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE Haemophilus influenzae Rd KW20

97.978

100

0.98
  comE Haemophilus influenzae 86-028NP

96.629

100

0.966
  comE Glaesserella parasuis strain SC1401

52.204

96.854

0.506
  pilQ Vibrio campbellii strain DS40M4

41.844

95.056

0.398
  pilQ Vibrio cholerae O1 biovar El Tor strain E7946

41.505

92.584

0.384
  pilQ Vibrio cholerae strain A1552

41.505

92.584

0.384

Multiple sequence alignment