NTDB

Overview

Name	ciaR	Type	Regulator
Locus tag	PW252_RS04990	Genome accession	NZ_CP118735
Coordinates	988208..988879 (+)	Length	223 a.a.
NCBI ID	WP_105117942.1	Uniprot ID	-
Organism	Streptococcus iners strain 29887
Function	repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IScluster/Tn	985896..993080	988208..988879	within	0

Gene organization within MGE regions

Location: 985896..993080

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
PW252_RS04980 (PW252_04980)	-	985896..987373 (+)	1478	Protein_937	IS1182 family transposase	-
PW252_RS04985 (PW252_04985)	-	987485..988066 (+)	582	WP_248043473.1	hypothetical protein	-
PW252_RS04990 (PW252_04990)	ciaR	988208..988879 (+)	672	WP_105117942.1	response regulator transcription factor	Regulator
PW252_RS04995 (PW252_04995)	ciaH	988872..990254 (+)	1383	WP_248051514.1	sensor histidine kinase	Regulator
PW252_RS05000 (PW252_05000)	-	990425..991654 (+)	1230	WP_248051512.1	transglutaminase domain-containing protein	-
PW252_RS05005 (PW252_05005)	-	991824..993080 (+)	1257	WP_316716633.1	ISL3 family transposase	-

Sequence

Protein

Download Length: 223 a.a. Molecular weight: 25269.94 Da Isoelectric Point: 4.3102

                                >NTDB_id=794737 PW252_RS04990 WP_105117942.1 988208..988879(+) (ciaR) [Streptococcus iners strain 29887]

MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGEEGIYEAESGVYDLILLDLMLPEKDGFQVLKELREKGVTTPVLITTA

KESLEDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNDNQLTYGDVTVDLATNSTKVDGKEVELLGKEFELLVY

FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKVRKKLKGTAFGENLQTLRSVGYILKNV

Nucleotide

Download Length: 672 bp

                                >NTDB_id=794737 PW252_RS04990 WP_105117942.1 988208..988879(+) (ciaR) [Streptococcus iners strain 29887]

ATGATAAAGATTTTGTTAGTAGAAGACGATTTAAGCCTATCCAATTCAGTTTTTGACTTCCTAGATGATTTTGCAGATGT

TATGCAAGTTTTCGATGGAGAAGAAGGAATTTATGAGGCTGAGTCAGGTGTGTATGACCTTATTCTCTTGGACTTGATGT

TGCCTGAGAAGGATGGCTTCCAAGTCTTGAAAGAATTGCGTGAAAAAGGAGTGACAACCCCTGTCCTGATTACAACAGCC

AAGGAAAGTCTTGAAGATAAAGGTCATGGATTTGAATTGGGTGCGGACGATTATTTGACCAAGCCTTTCTATTTGGAAGA

GTTGAAAATGCGTATTCAAGCCCTCCTTAAACGTTCAGGTAAATTCAACGACAATCAATTGACCTACGGTGATGTGACAG

TTGATCTTGCGACTAATTCCACAAAGGTAGATGGTAAAGAGGTTGAACTATTGGGCAAAGAGTTTGAACTATTGGTCTAT

TTCCTACAAAATCAAAATGTTATCCTACCTAAGACACAGATTTTCGATCGCTTGTGGGGATTTGACAGCGATACGACCAT

TTCAGTAGTGGAAGTTTATGTGTCAAAAGTTCGTAAAAAATTGAAAGGAACGGCCTTCGGGGAAAATCTGCAAACCCTTC

GCAGTGTCGGCTACATTCTAAAGAATGTTTAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
ciaR	Streptococcus pneumoniae TIGR4	89.238	100	0.892
ciaR	Streptococcus pneumoniae Rx1	89.238	100	0.892
ciaR	Streptococcus pneumoniae D39	89.238	100	0.892
ciaR	Streptococcus pneumoniae R6	89.238	100	0.892
ciaR	Streptococcus mutans UA159	88.789	100	0.888
micA	Streptococcus pneumoniae Cp1015	36.052	100	0.377
covR	Lactococcus lactis subsp. lactis strain DGCC12653	36.889	100	0.372
vicR	Streptococcus mutans UA159	35.47	100	0.372

Detailed information NTG0794737