Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   PW252_RS04995 Genome accession   NZ_CP118735
Coordinates   988872..990254 (+) Length   460 a.a.
NCBI ID   WP_248051514.1    Uniprot ID   A0AA96VVJ0
Organism   Streptococcus iners strain 29887     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
IScluster/Tn 985896..993080 988872..990254 within 0


Gene organization within MGE regions


Location: 985896..993080
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  PW252_RS04980 (PW252_04980) - 985896..987373 (+) 1478 Protein_937 IS1182 family transposase -
  PW252_RS04985 (PW252_04985) - 987485..988066 (+) 582 WP_248043473.1 hypothetical protein -
  PW252_RS04990 (PW252_04990) ciaR 988208..988879 (+) 672 WP_105117942.1 response regulator transcription factor Regulator
  PW252_RS04995 (PW252_04995) ciaH 988872..990254 (+) 1383 WP_248051514.1 sensor histidine kinase Regulator
  PW252_RS05000 (PW252_05000) - 990425..991654 (+) 1230 WP_248051512.1 transglutaminase domain-containing protein -
  PW252_RS05005 (PW252_05005) - 991824..993080 (+) 1257 WP_316716633.1 ISL3 family transposase -

Sequence

Protein


Download         Length: 460 a.a.        Molecular weight: 52018.59 Da        Isoelectric Point: 6.7074

>NTDB_id=794738 PW252_RS04995 WP_248051514.1 988872..990254(+) (ciaH) [Streptococcus iners strain 29887]
MFKRYKKIVNTESFSFFIRYFAVFTLIFGLMTAIIFQLMRSTMYQTTDDTLSWIKDEPSMMIGFAIARTYEPDSEFIIHD
ESEQPSATTSSSTTASSEAPPPKDKKGDQPMRLGTNTHVLLYSKSGALLNPDNFTGLSDLKVDKKKLGEIKELTVETPFG
SEEHYRYITVELSAEDLGYYSNYDITCATILVNVSQIKSSIGTYESTVAVVMISAWLISIVASIYLANLSMKPILISYQK
QKDFVENASHELRTPLAVLQNRLESLFRHPEATILDSSESIGSSLEEVRNMRLLTTNLLNLARRDDGFKLDMVEVSPAYL
DEVFENYRIIAEENGKKFKCNNLIQKSFRTDRVLLKQLLTILFDNAMKYTDENGDIHITATMKERHVSIAVADNGLGISD
ADKKKIFDRFYRVDKARTRQKGGFGLGLSLAQQIIKSLNGQILVKDNQPKGSIFEVHLPK

Nucleotide


Download         Length: 1383 bp        

>NTDB_id=794738 PW252_RS04995 WP_248051514.1 988872..990254(+) (ciaH) [Streptococcus iners strain 29887]
ATGTTTAAGAGATATAAAAAGATTGTCAATACGGAAAGTTTTTCCTTCTTCATTCGCTATTTTGCTGTATTTACCCTGAT
ATTTGGCTTGATGACAGCTATCATCTTTCAGCTCATGCGTTCCACTATGTATCAGACGACGGATGATACATTGAGTTGGA
TTAAGGATGAACCCTCTATGATGATAGGTTTTGCAATTGCGCGGACCTATGAGCCTGATTCTGAATTTATTATCCATGAT
GAAAGTGAGCAACCTTCTGCAACAACTTCCTCCTCAACTACTGCTTCATCGGAGGCTCCACCACCAAAGGATAAGAAAGG
TGATCAGCCAATGAGGTTAGGCACCAATACCCATGTTTTGCTCTATAGCAAGAGTGGTGCGCTTTTGAACCCGGATAATT
TTACAGGTTTATCCGATTTGAAAGTCGATAAAAAAAAGTTGGGGGAAATCAAGGAGTTGACGGTTGAAACTCCATTTGGT
TCTGAGGAACATTACCGCTATATCACGGTTGAATTATCCGCAGAGGATTTGGGCTATTATTCTAACTATGATATTACCTG
CGCAACGATTTTGGTCAATGTCAGCCAGATAAAGTCTTCTATTGGAACTTATGAATCGACTGTAGCTGTAGTTATGATTT
CAGCTTGGTTGATTTCGATTGTCGCTAGTATTTACTTGGCTAATCTCAGCATGAAACCAATTTTAATTAGCTATCAAAAG
CAAAAGGATTTTGTTGAGAATGCTAGCCACGAATTGCGTACACCACTAGCAGTATTGCAAAATCGTTTGGAAAGTCTATT
CCGTCATCCAGAAGCAACGATTTTGGACAGTAGTGAGAGTATTGGTTCTAGTCTGGAAGAAGTACGAAATATGCGCCTAC
TGACGACCAATCTGCTCAATCTTGCTCGGCGTGATGATGGATTTAAGTTAGATATGGTAGAGGTGAGCCCTGCCTACTTG
GATGAAGTGTTTGAAAACTACCGTATCATTGCTGAGGAAAATGGCAAGAAATTTAAGTGTAACAATCTCATTCAAAAGTC
CTTCCGAACGGACAGGGTTCTGTTGAAGCAATTATTAACGATATTATTTGATAATGCAATGAAATACACGGATGAGAATG
GTGATATTCACATTACGGCTACTATGAAGGAGCGCCATGTTTCCATCGCTGTAGCTGATAATGGTCTAGGTATCTCAGAT
GCAGATAAGAAGAAAATATTTGACCGCTTTTATAGGGTTGATAAGGCACGGACACGCCAAAAAGGTGGTTTTGGTCTGGG
ACTTTCTTTGGCTCAACAGATTATCAAATCCCTCAATGGTCAAATTCTTGTCAAAGATAATCAACCCAAAGGGAGTATTT
TTGAAGTCCATCTTCCCAAATAA

Domains

Predicted by InterproScan.

His Kinase A (phospho-acceptor) domain (HisKA)

(241-307)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(351-459)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

49.673

99.783

0.496
  ciaH Streptococcus pneumoniae D39

49.673

99.783

0.496
  ciaH Streptococcus pneumoniae R6

49.673

99.783

0.496
  ciaH Streptococcus pneumoniae TIGR4

49.673

99.783

0.496
  ciaH Streptococcus mutans UA159

48.817

100

0.493