Detailed information NTG0794695

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: PW220_RS05870
• Genome accession: NZ_CP118734
• Coordinates: 1171438..1172109 (-)
• Length: 223 a.a.
• NCBI ID: WP_105117942.1
• Uniprot ID: -
• Organism: Streptococcus iners subsp. hyiners strain 29892
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 1166438..1177109

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
PW220_RS05845 (PW220_05850)	-	1166686..1167276 (-)	591	WP_105117939.1	class I SAM-dependent methyltransferase	-
PW220_RS05850 (PW220_05855)	coaA	1167389..1168309 (+)	921	WP_105114818.1	type I pantothenate kinase	-
PW220_RS05855 (PW220_05860)	rpsT	1168368..1168616 (+)	249	WP_012027069.1	30S ribosomal protein S20	-
PW220_RS05860 (PW220_05865)	-	1168663..1169892 (-)	1230	WP_248055192.1	transglutaminase domain-containing protein	-
PW220_RS05865 (PW220_05870)	ciaH	1170063..1171445 (-)	1383	WP_248055191.1	sensor histidine kinase	Regulator
PW220_RS05870 (PW220_05875)	ciaR	1171438..1172109 (-)	672	WP_105117942.1	response regulator transcription factor	Regulator
PW220_RS05875 (PW220_05880)	-	1172251..1172679 (-)	429	WP_248055189.1	hypothetical protein	-
PW220_RS05880 (PW220_05885)	phoU	1172826..1173482 (-)	657	WP_105117944.1	phosphate signaling complex protein PhoU	-
PW220_RS05885 (PW220_05890)	pstB	1173510..1174268 (-)	759	WP_171998850.1	phosphate ABC transporter ATP-binding protein PstB	-
PW220_RS05890 (PW220_05895)	pstB	1174280..1175083 (-)	804	WP_172091490.1	phosphate ABC transporter ATP-binding protein PstB	-
PW220_RS05895 (PW220_05900)	pstA	1175108..1175995 (-)	888	WP_044758719.1	phosphate ABC transporter permease PstA	-
PW220_RS05900 (PW220_05905)	pstC	1175985..1176902 (-)	918	WP_029176378.1	phosphate ABC transporter permease subunit PstC	-

Sequence

Protein

• Length: 223 a.a.
• Molecular weight: 25269.94 Da
• Isoelectric Point: 4.3102

>NTDB_id=794695 PW220_RS05870 WP_105117942.1 1171438..1172109(-) (ciaR) [Streptococcus iners subsp. hyiners strain 29892]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGEEGIYEAESGVYDLILLDLMLPEKDGFQVLKELREKGVTTPVLITTA
KESLEDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNDNQLTYGDVTVDLATNSTKVDGKEVELLGKEFELLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKVRKKLKGTAFGENLQTLRSVGYILKNV

Nucleotide

• Length: 672 bp

>NTDB_id=794695 PW220_RS05870 WP_105117942.1 1171438..1172109(-) (ciaR) [Streptococcus iners subsp. hyiners strain 29892]
ATGATAAAGATTTTGTTGGTAGAAGATGATTTAAGTCTATCTAACTCTGTTTTTGATTTCCTGGATGACTTTGCAGATGT
CATGCAGGTTTTTGATGGAGAAGAAGGAATTTACGAGGCTGAGTCAGGTGTATATGACCTTATTCTCTTGGACTTGATGT
TGCCTGAGAAGGATGGCTTCCAAGTATTGAAAGAATTGCGTGAAAAAGGAGTGACAACCCCTGTTCTGATTACAACAGCC
AAGGAAAGTCTTGAAGATAAAGGTCATGGATTTGAATTGGGTGCGGACGATTATTTGACCAAGCCTTTCTATTTGGAAGA
GTTGAAAATGCGTATTCAAGCCCTCCTTAAACGTTCAGGTAAATTCAACGACAATCAATTGACCTACGGTGATGTGACAG
TTGATCTTGCGACTAATTCCACAAAGGTAGATGGTAAAGAAGTTGAACTACTGGGCAAAGAGTTTGAACTATTGGTCTAT
TTCCTACAAAATCAAAATGTTATCCTACCTAAGACACAGATTTTCGATCGCTTGTGGGGATTTGACAGCGATACGACCAT
TTCAGTAGTGGAAGTTTATGTGTCAAAAGTTCGTAAAAAATTGAAAGGAACGGCCTTCGGAGAAAATCTGCAAACCCTTC
GCAGTGTTGGCTACATTCTAAAGAATGTTTAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus pneumoniae TIGR4	89.238	100	0.892
ciaR	Streptococcus pneumoniae Rx1	89.238	100	0.892
ciaR	Streptococcus pneumoniae D39	89.238	100	0.892
ciaR	Streptococcus pneumoniae R6	89.238	100	0.892
ciaR	Streptococcus mutans UA159	88.789	100	0.888
micA	Streptococcus pneumoniae Cp1015	36.052	100	0.377
covR	Lactococcus lactis subsp. lactis strain DGCC12653	36.889	100	0.372
vicR	Streptococcus mutans UA159	35.47	100	0.372