Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   PUW49_RS04855 Genome accession   NZ_CP118054
Coordinates   968819..969493 (+) Length   224 a.a.
NCBI ID   WP_003024352.1    Uniprot ID   A0AAI9NIE3
Organism   Streptococcus anginosus strain VSI37     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 963819..974493
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  PUW49_RS04830 (PUW49_04830) - 965296..966255 (+) 960 WP_274995170.1 ROK family glucokinase -
  PUW49_RS04835 (PUW49_04835) rplS 966407..966754 (+) 348 WP_003024326.1 50S ribosomal protein L19 -
  PUW49_RS04845 (PUW49_04845) - 966995..967738 (+) 744 WP_070241645.1 alpha/beta hydrolase -
  PUW49_RS04850 (PUW49_04850) - 968086..968544 (+) 459 WP_070811473.1 hypothetical protein -
  PUW49_RS04855 (PUW49_04855) ciaR 968819..969493 (+) 675 WP_003024352.1 response regulator transcription factor Regulator
  PUW49_RS04860 (PUW49_04860) ciaH 969483..970829 (+) 1347 WP_150867752.1 HAMP domain-containing sensor histidine kinase Regulator
  PUW49_RS04865 (PUW49_04865) - 971263..972711 (-) 1449 WP_024052210.1 alpha-amylase -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25359.01 Da        Isoelectric Point: 4.2408

>NTDB_id=789674 PUW49_RS04855 WP_003024352.1 968819..969493(+) (ciaR) [Streptococcus anginosus strain VSI37]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKDGFQVLKELREKGVTTPVLIMTA
KESLNDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLSYGDVTVNLSTNTTLVDGNEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKIRKKLKGTTFANNLQTLRSVGYILKDAE

Nucleotide


Download         Length: 675 bp        

>NTDB_id=789674 PUW49_RS04855 WP_003024352.1 968819..969493(+) (ciaR) [Streptococcus anginosus strain VSI37]
ATGATTAAGATTCTATTAGTGGAAGACGACCTCGGTCTATCTAATTCGGTATTTGATTTTTTGGATGATTTTGCAGATGT
CATGCAAGTTTTTGACGGTGAGGAAGGATTGTACGAGGCCGAGAGTGGCGTGTACGACCTTATCTTGCTTGATTTGATGT
TGCCAGAAAAAGACGGTTTCCAAGTATTGAAAGAATTGCGTGAAAAAGGCGTTACCACACCTGTTTTGATTATGACAGCC
AAAGAAAGTTTGAATGATAAAGGACATGGTTTTGAACTGGGAGCTGACGATTATTTGACCAAACCATTTTATTTGGAAGA
GTTAAAAATGCGGATTCAAGCTCTCTTGAAGCGTTCTGGCAAGTTCAATGAAAACACCCTTTCTTATGGCGATGTCACTG
TTAATTTATCAACAAACACTACACTTGTAGACGGAAATGAAGTAGAATTGCTCGGAAAAGAATTTGACTTGCTGGTGTAT
TTCTTGCAAAATCAAAATGTTATTCTACCGAAGACGCAGATTTTCGATCGATTATGGGGGTTTGATAGTGATACAACCAT
TTCAGTCGTAGAAGTCTATGTTTCAAAAATCCGGAAAAAATTGAAAGGGACGACCTTTGCGAACAATCTTCAAACGCTTC
GCAGCGTCGGATATATTTTAAAAGATGCTGAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

91.964

100

0.92
  ciaR Streptococcus pneumoniae D39

91.964

100

0.92
  ciaR Streptococcus pneumoniae R6

91.964

100

0.92
  ciaR Streptococcus pneumoniae TIGR4

91.964

100

0.92
  ciaR Streptococcus mutans UA159

90.135

99.554

0.897
  covR Lactococcus lactis subsp. lactis strain DGCC12653

38.767

100

0.393
  vicR Streptococcus mutans UA159

36.052

100

0.375
  covR Streptococcus salivarius strain HSISS4

35.683

100

0.362