NTDB

Overview

Name	ciaH	Type	Regulator
Locus tag	PUW49_RS04860	Genome accession	NZ_CP118054
Coordinates	969483..970829 (+)	Length	448 a.a.
NCBI ID	WP_150867752.1	Uniprot ID	-
Organism	Streptococcus anginosus strain VSI37
Function	repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 964483..975829

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
PUW49_RS04830 (PUW49_04830)	-	965296..966255 (+)	960	WP_274995170.1	ROK family glucokinase	-
PUW49_RS04835 (PUW49_04835)	rplS	966407..966754 (+)	348	WP_003024326.1	50S ribosomal protein L19	-
PUW49_RS04845 (PUW49_04845)	-	966995..967738 (+)	744	WP_070241645.1	alpha/beta hydrolase	-
PUW49_RS04850 (PUW49_04850)	-	968086..968544 (+)	459	WP_070811473.1	hypothetical protein	-
PUW49_RS04855 (PUW49_04855)	ciaR	968819..969493 (+)	675	WP_003024352.1	response regulator transcription factor	Regulator
PUW49_RS04860 (PUW49_04860)	ciaH	969483..970829 (+)	1347	WP_150867752.1	HAMP domain-containing sensor histidine kinase	Regulator
PUW49_RS04865 (PUW49_04865)	-	971263..972711 (-)	1449	WP_024052210.1	alpha-amylase	-
PUW49_RS04870 (PUW49_04870)	-	972888..974504 (+)	1617	WP_024052209.1	M20/M25/M40 family metallo-hydrolase	-
PUW49_RS04875 (PUW49_04875)	-	974553..975062 (-)	510	WP_070811475.1	DNA topology modulation protein	-
PUW49_RS04880 (PUW49_04880)	rpsT	975126..975377 (-)	252	WP_020999623.1	30S ribosomal protein S20	-

Sequence

Protein

Download Length: 448 a.a. Molecular weight: 51040.71 Da Isoelectric Point: 10.0956

                                >NTDB_id=789675 PUW49_RS04860 WP_150867752.1 969483..970829(+) (ciaH) [Streptococcus anginosus strain VSI37]

MLNKLKKTWYADDFSYFIRNFGIFTLIFSAMTLIIIQVMRSSLYTTVDNNLKSLSQDSASVINLALARRVGMEQKSDNGE

PKTDTGDKELTDKPNVSANTEVILFDKNYKPIITSNNFLGLNKLSFNSKQLDRIRQVQVKSNYGRQETYRMILFEVKIPN

LETNVKYAAVFINISQLEQTSQNHEQLIVVVMISFWGISLIASVYLARVSVKPLLESIQKQKSFVENASHELRTPLAVLQ

NRLETLFRKPESTIMESSESIASSLDEVRNMKMLTTNLLNLARRDDGIKPEIGDVEPNFFNTTFTNYEMVAAENGKTFRF

DNRIHRMIKTDKTLLKQLMTILFDNALKYTDEDGVIELTISANDRNLFLKVSDNGPGISTADKKKIFDRFYRVDKARTRQ

TGGFGLGLSLAKQITEALKGTITVKDNKPKGTIFEVKIAIRTDNRKNK

Nucleotide

Download Length: 1347 bp

                                >NTDB_id=789675 PUW49_RS04860 WP_150867752.1 969483..970829(+) (ciaH) [Streptococcus anginosus strain VSI37]

ATGCTGAATAAACTTAAAAAAACATGGTATGCGGATGATTTTTCTTATTTCATTCGCAATTTTGGTATTTTTACTCTCAT

TTTCTCAGCCATGACTTTGATTATCATTCAGGTGATGCGCTCAAGCCTTTATACAACGGTCGATAATAACTTGAAAAGTC

TCAGTCAGGATTCCGCTTCTGTCATCAATTTGGCGCTCGCTCGGAGAGTGGGGATGGAACAGAAGTCAGACAACGGAGAG

CCTAAAACCGACACGGGTGACAAAGAGCTTACTGATAAACCAAATGTCAGTGCCAATACGGAAGTTATTTTATTTGATAA

GAATTATAAGCCAATCATTACAAGCAATAATTTTCTGGGACTTAATAAACTTTCCTTTAATAGCAAGCAATTGGATCGCA

TTCGGCAAGTCCAGGTTAAAAGCAATTATGGTCGACAAGAAACCTATCGGATGATTTTATTTGAAGTGAAAATCCCAAAT

TTGGAAACCAATGTCAAATATGCAGCGGTCTTTATCAATATCAGTCAGTTGGAACAAACTAGTCAAAATCATGAGCAGCT

GATTGTAGTTGTGATGATTAGTTTCTGGGGAATTTCCTTGATTGCCAGTGTCTATCTGGCTCGAGTTAGTGTTAAACCTT

TGTTGGAAAGCATTCAAAAGCAAAAGAGTTTTGTCGAAAATGCCAGTCATGAGTTGCGCACACCTCTAGCTGTTTTACAA

AATCGTTTGGAGACTTTGTTTAGAAAACCAGAATCCACCATTATGGAATCAAGCGAAAGCATTGCTTCTAGTTTGGATGA

AGTGCGGAACATGAAAATGTTGACGACAAATCTGCTTAATCTAGCACGGCGTGACGACGGGATTAAACCAGAAATTGGCG

ATGTCGAGCCAAATTTCTTTAATACGACCTTTACCAACTATGAAATGGTTGCCGCAGAAAATGGGAAAACTTTCCGATTT

GACAATAGGATTCACCGCATGATTAAAACAGACAAGACCTTGCTGAAGCAATTAATGACGATTCTGTTTGACAATGCTCT

GAAATATACAGATGAAGACGGTGTGATTGAATTGACAATCTCTGCAAATGATCGAAATTTGTTTTTAAAGGTTTCAGATA

ATGGTCCGGGGATTAGTACGGCAGATAAGAAAAAGATTTTTGATCGTTTTTATCGGGTTGATAAAGCACGGACTCGGCAG

ACAGGTGGTTTTGGTCTAGGCTTGTCGCTTGCAAAGCAAATCACAGAAGCTCTTAAAGGAACTATTACGGTGAAAGATAA

TAAGCCGAAAGGAACTATTTTTGAGGTGAAGATTGCCATTAGAACGGACAATAGAAAGAATAAATAA

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(331-438)

His Kinase A (phospho-acceptor) domain (HisKA)

(222-287)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
ciaH	Streptococcus pneumoniae Rx1	70.982	100	0.71
ciaH	Streptococcus pneumoniae D39	70.982	100	0.71
ciaH	Streptococcus pneumoniae R6	70.982	100	0.71
ciaH	Streptococcus pneumoniae TIGR4	70.982	100	0.71
ciaH	Streptococcus mutans UA159	55.782	98.438	0.549

Detailed information NTG0789675