Detailed information NTG0078790

Bioinformatically predicted

Overview

• Name: dprA/cilB/dalA
• Type: Machinery gene
• Locus tag: QML87_RS04425
• Genome accession: NZ_AP025936
• Coordinates: 879329..880177 (+)
• Length: 282 a.a.
• NCBI ID: WP_000705306.1
• Uniprot ID: Q8DPI7
• Organism: Streptococcus pneumoniae strain PZ900700617
• Function: ssDNA binding; loading RecA onto ssDNA; competence shut-off (predicted from homology) DNA processing Competence regulation

Genomic Context

Location: 874329..885177

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
QML87_RS04400 (PC0607_08690)	-	875044..875751 (+)	708	WP_000638483.1	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-
QML87_RS04405 (PC0607_08700)	-	875756..876778 (+)	1023	WP_000609917.1	ribitol-5-phosphate dehydrogenase	-
QML87_RS04410 (PC0607_08710)	licA	876795..877664 (+)	870	WP_000411212.1	choline kinase LicA	-
QML87_RS04415 (PC0607_08720)	-	877654..878532 (+)	879	WP_000837609.1	DMT family transporter	-
QML87_RS04420 (PC0607_08730)	-	878544..879233 (+)	690	WP_000643964.1	sugar phosphate nucleotidyltransferase	-
QML87_RS04425 (PC0607_08740)	dprA/cilB/dalA	879329..880177 (+)	849	WP_000705306.1	DNA-processing protein DprA	Machinery gene
QML87_RS04430 (PC0607_08750)	-	880747..881700 (-)	954	WP_001155321.1	IS30-like element ISSpn8 family transposase	-
QML87_RS04435 (PC0607_08760)	-	882308..883351 (+)	1044	WP_001812957.1	TIGR00341 family protein	-

Sequence

Protein

• Length: 282 a.a.
• Molecular weight: 31062.72 Da
• Isoelectric Point: 5.4047

>NTDB_id=78790 QML87_RS04425 WP_000705306.1 879329..880177(+) (dprA/cilB/dalA) [Streptococcus pneumoniae strain PZ900700617]
MKITNYEIYKLKKSGLTNQQILKVLEYGENVDQELLLGDIADISGCRNPAVFMERYFQIDDAHLSKEFQKFPSFSILDDC
YPWDLSEIYDAPVLLFYKGNLDLLKFPKVAVVGSRACSKQGAKSVEKVIQGLENELVIVSGLAKGIDTAAHMAALQNGGK
TIAVIGTGLDVFYPKANKRLQDYIGNDHLVLSEYGPGEQPLKFHFPARNRIIAGLCRGVIVAEAKMRSGSLITCERAMEE
GRDVFAIPGSILDGLSDGCHHLIQEGAKLVTSGQDVLAEFEF

Nucleotide

• Length: 849 bp

>NTDB_id=78790 QML87_RS04425 WP_000705306.1 879329..880177(+) (dprA/cilB/dalA) [Streptococcus pneumoniae strain PZ900700617]
ATGAAAATCACAAACTATGAAATCTATAAGTTAAAAAAATCAGGTTTGACCAATCAACAGATTTTGAAAGTGCTAGAATA
CGGTGAAAATGTTGATCAGGAGCTTTTGTTGGGTGATATTGCAGATATATCAGGTTGCCGTAATCCAGCCGTTTTTATGG
AACGTTATTTTCAGATAGACGATGCGCATTTGTCGAAAGAGTTTCAAAAATTTCCATCTTTCTCTATTTTAGATGACTGT
TATCCTTGGGATTTGAGTGAAATATATGATGCGCCTGTACTTTTATTTTACAAGGGAAATCTTGACCTCCTGAAATTCCC
GAAGGTAGCGGTCGTGGGCAGTCGTGCTTGTAGCAAACAGGGAGCTAAGTCAGTTGAAAAAGTCATTCAAGGCTTGGAAA
ATGAACTGGTTATTGTCAGTGGTCTGGCCAAGGGCATTGACACAGCAGCTCATATGGCAGCTCTTCAGAATGGCGGAAAA
ACCATTGCAGTGATTGGAACAGGACTGGATGTGTTTTATCCTAAAGCCAATAAACGCTTGCAAGACTACATCGGCAATGA
CCATCTGGTTCTAAGTGAATATGGACCTGGCGAACAACCTCTGAAATTTCATTTTCCTGCCCGTAATCGCATCATTGCTG
GACTTTGTCGTGGTGTGATTGTAGCAGAGGCTAAGATGCGTTCAGGTAGTCTCATTACGTGTGAGCGAGCAATGGAAGAA
GGACGCGATGTCTTTGCTATTCCTGGTAGCATTTTAGATGGACTATCAGACGGTTGCCATCATTTGATTCAAGAAGGAGC
AAAATTGGTCACCAGTGGGCAAGATGTTCTTGCGGAATTTGAATTTTAA

Domains

Predicted by InterProScan.

• DNA recombination-mediator protein A (DNA_processg_A) (75-271)

• DNA processing protein A sterile alpha motif domain (SAM_DprA) (3-64)

3D structure

• PDB: 3UQZ

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
dprA/cilB/dalA	Streptococcus pneumoniae Rx1	100	100	1
dprA/cilB/dalA	Streptococcus pneumoniae D39	100	100	1
dprA/cilB/dalA	Streptococcus pneumoniae R6	100	100	1
dprA/cilB/dalA	Streptococcus pneumoniae TIGR4	100	100	1
dprA/cilB/dalA	Streptococcus mitis NCTC 12261	98.582	100	0.986
dprA/cilB/dalA	Streptococcus mitis SK321	97.872	100	0.979
dprA	Streptococcus mutans UA159	63.214	99.291	0.628
dprA	Lactococcus lactis subsp. cremoris KW2	55.714	99.291	0.553
dprA	Staphylococcus aureus N315	37.809	100	0.379
dprA	Haemophilus influenzae Rd KW20	38.202	94.681	0.362