Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   LLL8_RS08420 Genome accession   NZ_AP025700
Coordinates   1725511..1726179 (-) Length   222 a.a.
NCBI ID   WP_021722129.1    Uniprot ID   -
Organism   Lactococcus lactis strain L8     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1720511..1731179
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  LLL8_RS08405 (LLL8_16470) yidD 1721775..1722041 (-) 267 WP_012898265.1 membrane protein insertion efficiency factor YidD -
  LLL8_RS08410 (LLL8_16480) - 1722158..1723900 (-) 1743 WP_015426860.1 1-deoxy-D-xylulose-5-phosphate synthase -
  LLL8_RS08415 (LLL8_16490) ciaH 1724048..1725418 (-) 1371 WP_003130363.1 HAMP domain-containing sensor histidine kinase Regulator
  LLL8_RS08420 (LLL8_16500) ciaR 1725511..1726179 (-) 669 WP_021722129.1 response regulator transcription factor Regulator
  LLL8_RS08425 (LLL8_16510) - 1726357..1727331 (-) 975 WP_058206283.1 LacI family DNA-binding transcriptional regulator -
  LLL8_RS08430 (LLL8_16520) - 1727484..1729739 (-) 2256 WP_251899771.1 glycoside hydrolase family 65 protein -

Sequence

Protein


Download         Length: 222 a.a.        Molecular weight: 25516.42 Da        Isoelectric Point: 4.4864

>NTDB_id=78546 LLL8_RS08420 WP_021722129.1 1725511..1726179(-) (ciaR) [Lactococcus lactis strain L8]
MIKILLVEDDLSLSKSVYDFLKSFAQVKQVYDGVEGLYEAELGIYDLILLDLMLPEKNGFEVLKELREQNVDTPVLIMTA
KESLDDKMHGFDIGADDYLTKPFYLDELKARIQALLKRTGKLEDSNGLTYGNIRLNLSNKSTLVDDQPVDLIGKEFDLVV
YLMQNQNVILPKEQIFDRIWGYDSDTTVTVVEVYMSKIRKKLKDTEFVNNLSTLRNVGYILR

Nucleotide


Download         Length: 669 bp        

>NTDB_id=78546 LLL8_RS08420 WP_021722129.1 1725511..1726179(-) (ciaR) [Lactococcus lactis strain L8]
ATGATTAAAATTTTATTAGTGGAGGATGATTTATCACTCTCAAAATCTGTTTACGATTTCTTAAAATCATTTGCGCAAGT
CAAACAGGTTTATGATGGTGTTGAAGGACTCTATGAGGCAGAATTGGGAATCTATGATTTAATTTTGCTTGATTTAATGC
TTCCAGAAAAGAATGGTTTTGAAGTCTTAAAGGAATTACGTGAGCAAAATGTAGATACGCCAGTCTTAATCATGACTGCT
AAGGAATCTTTGGATGATAAAATGCACGGATTCGACATTGGAGCAGATGATTATTTAACAAAACCTTTCTATTTAGATGA
ACTAAAAGCACGTATTCAAGCACTTTTGAAACGGACAGGTAAATTAGAAGATTCAAACGGTTTAACTTATGGAAATATTC
GTTTGAATTTATCAAATAAATCAACTTTAGTTGATGATCAACCTGTTGATTTAATCGGAAAAGAATTTGATTTAGTCGTT
TATTTAATGCAAAATCAAAATGTTATTTTGCCAAAAGAGCAAATTTTTGACCGGATTTGGGGTTATGACAGTGATACAAC
AGTAACTGTTGTTGAAGTTTATATGAGTAAAATTCGGAAAAAATTGAAAGATACAGAATTTGTCAATAATCTTTCAACTT
TGCGAAATGTTGGCTATATCTTGAGATAA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(4-113)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-221)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

74.775

100

0.748
  ciaR Streptococcus pneumoniae D39

74.775

100

0.748
  ciaR Streptococcus pneumoniae R6

74.775

100

0.748
  ciaR Streptococcus pneumoniae TIGR4

74.775

100

0.748
  ciaR Streptococcus mutans UA159

72.973

100

0.73
  covR Lactococcus lactis subsp. lactis strain DGCC12653

38.667

100

0.392
  covR Streptococcus salivarius strain HSISS4

37.333

100

0.378
  vicR Streptococcus mutans UA159

34.764

100

0.365
  micA Streptococcus pneumoniae Cp1015

34.483

100

0.36