Detailed information NTG0780030

Bioinformatically predicted

Overview

• Name: vicR
• Type: Regulator
• Locus tag: PND17_RS02615
• Genome accession: NZ_CP116772
• Coordinates: 500891..501598 (-)
• Length: 235 a.a.
• NCBI ID: WP_173940375.1
• Uniprot ID: A0A2H4K9R7
• Organism: Streptococcus thermophilus strain strain TSGB 4141
• Function: repress comCDE expression; repress comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 495891..506598

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
PND17_RS02590 (PND17_02590)	yidA	496243..497052 (+)	810	WP_011226081.1	sugar-phosphatase	-
PND17_RS02595 (PND17_02595)	-	497054..498268 (+)	1215	WP_065973253.1	aminoacyltransferase	-
PND17_RS02600 (PND17_02600)	-	498320..498680 (-)	361	Protein_506	YbaN family protein	-
PND17_RS02605 (PND17_02605)	vicX	498740..499552 (-)	813	WP_271298199.1	MBL fold metallo-hydrolase	Regulator
PND17_RS02610 (PND17_02610)	vicK	499558..500898 (-)	1341	WP_011227273.1	cell wall metabolism sensor histidine kinase VicK	Regulator
PND17_RS02615 (PND17_02615)	vicR	500891..501598 (-)	708	WP_173940375.1	response regulator YycF	Regulator
PND17_RS02620 (PND17_02620)	-	502125..502892 (+)	768	WP_011227275.1	amino acid ABC transporter ATP-binding protein	-
PND17_RS02625 (PND17_02625)	-	502904..503737 (+)	834	WP_232975083.1	transporter substrate-binding domain-containing protein	-
PND17_RS02630 (PND17_02630)	-	503755..504453 (+)	699	WP_271298507.1	amino acid ABC transporter permease	-
PND17_RS02635 (PND17_02635)	-	504465..505115 (+)	651	WP_011226088.1	amino acid ABC transporter permease	-
PND17_RS02640 (PND17_02640)	endA	505186..506067 (-)	882	WP_271298197.1	DNA/RNA non-specific endonuclease	Machinery gene
PND17_RS02645 (PND17_02645)	-	506129..506317 (-)	189	WP_011226090.1	DNA-directed RNA polymerase subunit beta	-

Sequence

Protein

• Length: 235 a.a.
• Molecular weight: 27087.04 Da
• Isoelectric Point: 5.0130

>NTDB_id=780030 PND17_RS02615 WP_173940375.1 500891..501598(-) (vicR) [Streptococcus thermophilus strain strain TSGB 4141]
MKKILVVDDERPISDIIKFNLTKEGYEVVTAFDGREALEQFEAKKPDLVILDLMLPELDGLEIAKEIRKTSHTPIIMLSA
KDSEFDKVIGLEIGADDYVTKPFSNRELLARIKAHLRRTETIETAVEESSNSGKQEISIGELIIVPDAFVAKKRGNEVEL
THREFELLFHLATHMGQVMTREHLLETVWGYDYFGDVRTVDVTIRRLREKIEDTPSRPEYILTRRGVGYYMKNYD

Nucleotide

• Length: 708 bp

>NTDB_id=780030 PND17_RS02615 WP_173940375.1 500891..501598(-) (vicR) [Streptococcus thermophilus strain strain TSGB 4141]
ATGAAAAAAATTCTAGTTGTTGATGATGAAAGACCAATCTCCGATATCATCAAGTTTAACCTTACTAAGGAGGGTTATGA
AGTGGTTACGGCCTTTGATGGGCGAGAAGCTTTGGAACAATTTGAAGCTAAAAAACCAGACTTGGTTATTCTGGACTTGA
TGTTGCCAGAACTGGATGGTTTGGAAATTGCCAAGGAAATCCGTAAAACGAGCCACACACCGATTATCATGCTTTCAGCT
AAAGATAGTGAGTTTGATAAGGTTATCGGATTAGAAATTGGGGCAGACGACTATGTGACTAAGCCATTTTCTAACCGTGA
ATTGTTGGCACGTATTAAAGCCCACTTGCGTCGTACAGAAACGATTGAAACGGCAGTAGAAGAGAGCTCTAACTCTGGCA
AACAAGAAATTTCAATTGGTGAGTTGATTATTGTTCCGGATGCCTTTGTTGCTAAAAAACGTGGAAACGAAGTTGAGTTG
ACCCACCGTGAATTTGAGTTACTCTTTCATTTGGCAACTCATATGGGACAAGTTATGACGCGTGAACATTTGCTTGAAAC
CGTTTGGGGCTATGACTATTTTGGGGATGTTCGTACTGTGGACGTAACGATTCGTCGTCTGCGTGAAAAAATTGAAGATA
CACCTAGCCGTCCTGAATATATCTTGACGCGTCGTGGTGTCGGTTATTACATGAAGAATTATGACTAG

Domains

Predicted by InterproScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (155-230)

• Response regulator receiver domain (Response_reg) (4-113)

3D structure

• AlphaFold DB: A0A2H4K9R7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vicR	Streptococcus mutans UA159	85.106	100	0.851
micA	Streptococcus pneumoniae Cp1015	79.828	99.149	0.791
covR	Lactococcus lactis subsp. lactis strain DGCC12653	45.455	98.298	0.447
covR	Streptococcus salivarius strain HSISS4	44.872	99.574	0.447
scnR	Streptococcus mutans UA159	38.136	100	0.383