NTDB

Overview

Name	ciaR	Type	Regulator
Locus tag	PHA78_RS04255	Genome accession	NZ_CP116604
Coordinates	852870..853541 (+)	Length	223 a.a.
NCBI ID	WP_014637852.1	Uniprot ID	G7SGW2
Organism	Streptococcus sp. HN38
Function	repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 847870..858541

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
PHA78_RS04225	pstC	847949..848866 (+)	918	WP_002937619.1	phosphate ABC transporter permease subunit PstC	-
PHA78_RS04230	pstA	848856..849743 (+)	888	WP_029178759.1	phosphate ABC transporter permease PstA	-
PHA78_RS04235	pstB	849768..850571 (+)	804	WP_029187991.1	phosphate ABC transporter ATP-binding protein PstB	-
PHA78_RS04240	pstB	850583..851341 (+)	759	WP_002937614.1	phosphate ABC transporter ATP-binding protein PstB	-
PHA78_RS04245	phoU	851370..852026 (+)	657	WP_002940865.1	phosphate signaling complex protein PhoU	-
PHA78_RS04250	-	852176..852724 (+)	549	WP_257213254.1	hypothetical protein	-
PHA78_RS04255	ciaR	852870..853541 (+)	672	WP_014637852.1	response regulator transcription factor	Regulator
PHA78_RS04260	ciaH	853534..854913 (+)	1380	WP_099807063.1	HAMP domain-containing sensor histidine kinase	Regulator
PHA78_RS04265	-	855099..856244 (+)	1146	WP_272158475.1	transglutaminase domain-containing protein	-
PHA78_RS04270	-	856458..857493 (+)	1036	WP_099778716.1	IS630 family transposase	-
PHA78_RS04275	rpsT	857600..857848 (-)	249	WP_012027069.1	30S ribosomal protein S20	-

Sequence

Protein

Download Length: 223 a.a. Molecular weight: 25245.83 Da Isoelectric Point: 4.2183

                                >NTDB_id=778762 PHA78_RS04255 WP_014637852.1 852870..853541(+) (ciaR) [Streptococcus sp. HN38]

MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGEEGIYEAETGVYDLILLDLMLPEKDGFQVLKELREKGVTTPVLITTA

KESLEDKGHGFELGADDYLTKPFYLEELKMRIQALLKRAGKFNENTLTYGDVTVDLSTNSTTVNGEEVELLGKEFDLLVY

FLQNQNVILPKTQIFDRIWGFDSDTTISVVEVYVSKIRKKLKGTTFGENLQTLRSVGYILKNA

Nucleotide

Download Length: 672 bp

                                >NTDB_id=778762 PHA78_RS04255 WP_014637852.1 852870..853541(+) (ciaR) [Streptococcus sp. HN38]

ATGATTAAGATTTTGTTAGTAGAAGACGATTTAAGCCTATCCAATTCAGTTTTTGACTTCCTAGATGATTTTGCGGATGT

TATGCAGGTTTTTGATGGTGAAGAAGGAATCTATGAAGCGGAAACTGGTGTGTACGACTTAATTTTATTAGATTTAATGT

TACCTGAAAAAGACGGCTTTCAAGTCTTGAAAGAGTTACGTGAAAAAGGTGTTACAACTCCTGTTCTGATTACAACAGCC

AAGGAAAGTCTAGAGGATAAAGGCCATGGTTTTGAATTGGGCGCTGATGACTACTTGACAAAACCGTTTTATTTAGAAGA

ATTGAAGATGCGAATTCAAGCTCTATTAAAACGAGCGGGTAAGTTTAATGAAAACACACTAACTTATGGGGACGTGACCG

TTGACTTATCGACAAACTCTACAACTGTAAATGGCGAAGAAGTTGAATTGCTAGGAAAAGAATTCGATCTACTAGTCTAC

TTTTTGCAAAATCAAAATGTTATCTTACCCAAAACTCAAATTTTTGACCGTATTTGGGGATTTGACAGTGACACTACTAT

TTCAGTAGTAGAAGTATATGTTTCTAAAATTAGGAAAAAGTTGAAAGGAACGACCTTCGGGGAAAATCTTCAAACCCTAC

GTAGTGTCGGATACATTCTAAAAAATGCCTAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)

Response regulator receiver domain (Response_reg)

(4-112)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	G7SGW2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
ciaR	Streptococcus mutans UA159	90.135	100	0.901
ciaR	Streptococcus pneumoniae Rx1	88.789	100	0.888
ciaR	Streptococcus pneumoniae D39	88.789	100	0.888
ciaR	Streptococcus pneumoniae R6	88.789	100	0.888
ciaR	Streptococcus pneumoniae TIGR4	88.789	100	0.888
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.053	100	0.386
vicR	Streptococcus mutans UA159	35.47	100	0.372
covR	Streptococcus salivarius strain HSISS4	36.283	100	0.368

Detailed information NTG0778762