Detailed information NTG0777113

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: PFZ59_RS10090
• Genome accession: NZ_CP116393
• Coordinates: 2011940..2012611 (-)
• Length: 223 a.a.
• NCBI ID: WP_024385291.1
• Uniprot ID: A0A116K182
• Organism: Streptococcus suis strain SS/UPM/MY/F001
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 2006940..2017611

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
PFZ59_RS10065 (PFZ59_10065)	-	2007049..2007639 (-)	591	WP_024376492.1	class I SAM-dependent methyltransferase	-
PFZ59_RS10070 (PFZ59_10070)	coaA	2007748..2008668 (+)	921	WP_208582251.1	type I pantothenate kinase	-
PFZ59_RS10075 (PFZ59_10075)	rpsT	2008727..2008975 (+)	249	WP_012027069.1	30S ribosomal protein S20	-
PFZ59_RS10080 (PFZ59_10080)	-	2009238..2010467 (-)	1230	WP_277696989.1	transglutaminase domain-containing protein	-
PFZ59_RS10085 (PFZ59_10085)	ciaH	2010568..2011947 (-)	1380	WP_208582771.1	HAMP domain-containing sensor histidine kinase	Regulator
PFZ59_RS10090 (PFZ59_10090)	ciaR	2011940..2012611 (-)	672	WP_024385291.1	response regulator transcription factor	Regulator
PFZ59_RS10095 (PFZ59_10095)	-	2012805..2013104 (-)	300	WP_277696990.1	hypothetical protein	-
PFZ59_RS10100 (PFZ59_10100)	-	2013629..2014832 (+)	1204	Protein_1949	IS110 family transposase	-
PFZ59_RS10105 (PFZ59_10105)	phoU	2015035..2015691 (-)	657	WP_024413748.1	phosphate signaling complex protein PhoU	-
PFZ59_RS10110 (PFZ59_10110)	pstB	2015718..2016476 (-)	759	WP_029186694.1	phosphate ABC transporter ATP-binding protein PstB	-
PFZ59_RS10115 (PFZ59_10115)	pstB	2016488..2017291 (-)	804	WP_044683430.1	phosphate ABC transporter ATP-binding protein PstB	-

Sequence

Protein

• Length: 223 a.a.
• Molecular weight: 25231.80 Da
• Isoelectric Point: 4.2183

>NTDB_id=777113 PFZ59_RS10090 WP_024385291.1 2011940..2012611(-) (ciaR) [Streptococcus suis strain SS/UPM/MY/F001]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGEEGVYEAETGVYDLILLDLMLPEKDGFQVLKELREKGVTTPVLITTA
KESLEDKGHGFELGADDYLTKPFYLEELKMRIQALLKRAGKFNENTLTYGDVTVDLSTNSTTVNGEEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRIWGFDSDTTISVVEVYVSKIRKKLKGTTFGENLQTLRSVGYILKNA

Nucleotide

• Length: 672 bp

>NTDB_id=777113 PFZ59_RS10090 WP_024385291.1 2011940..2012611(-) (ciaR) [Streptococcus suis strain SS/UPM/MY/F001]
ATGATTAAAATATTGTTAGTGGAAGATGATTTAAGCCTATCAAATTCTGTTTTCGATTTCTTAGATGATTTTGCGGATGT
TATGCAGGTTTTTGATGGTGAAGAGGGCGTTTATGAGGCGGAAACAGGCGTTTATGATTTGATTCTTTTGGATTTGATGT
TGCCTGAAAAAGATGGCTTCCAAGTTTTGAAAGAGTTACGTGAAAAAGGTGTTACGACACCTGTTCTGATTACAACAGCC
AAGGAAAGTCTAGAGGATAAAGGCCATGGTTTTGAATTGGGAGCTGATGACTACTTGACAAAACCGTTTTATTTAGAAGA
ATTGAAGATGCGAATTCAAGCTCTATTAAAACGAGCGGGTAAGTTTAATGAAAACACACTAACTTATGGGGACGTGACCG
TTGACTTATCGACAAACTCTACAACTGTAAATGGCGAAGAAGTTGAATTGCTAGGAAAAGAATTCGATCTACTCGTCTAC
TTCTTGCAAAATCAAAATGTTATCTTACCAAAAACTCAAATTTTTGACCGTATTTGGGGATTTGACAGTGACACTACTAT
TTCAGTAGTAGAAGTATATGTTTCTAAAATTAGGAAAAAGTTGAAAGGAACGACCTTTGGGGAAAATCTTCAAACCCTGC
GTAGTGTCGGGTACATTCTAAAAAATGCCTAA

Domains

Predicted by InterproScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

• Response regulator receiver domain (Response_reg) (4-112)

3D structure

• AlphaFold DB: A0A116K182

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus mutans UA159	90.135	100	0.901
ciaR	Streptococcus pneumoniae Rx1	88.789	100	0.888
ciaR	Streptococcus pneumoniae D39	88.789	100	0.888
ciaR	Streptococcus pneumoniae R6	88.789	100	0.888
ciaR	Streptococcus pneumoniae TIGR4	88.789	100	0.888
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.053	100	0.386
vicR	Streptococcus mutans UA159	35.47	100	0.372
covR	Streptococcus salivarius strain HSISS4	36.283	100	0.368