Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   OQG81_RS06060 Genome accession   NZ_CP113440
Coordinates   1136358..1137032 (-) Length   224 a.a.
NCBI ID   WP_014294586.1    Uniprot ID   A0A380K9T7
Organism   Streptococcus macedonicus strain E37     
Function   repress competence development (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 1133280..1141330 1136358..1137032 within 0


Gene organization within MGE regions


Location: 1133280..1141330
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  OQG81_RS06045 (OQG81_06045) - 1133280..1134443 (-) 1164 WP_265631676.1 IS30 family transposase -
  OQG81_RS06050 (OQG81_06050) rpsT 1134640..1134891 (+) 252 WP_081498578.1 30S ribosomal protein S20 -
  OQG81_RS06055 (OQG81_06055) ciaH 1135028..1136368 (-) 1341 WP_039670832.1 sensor histidine kinase Regulator
  OQG81_RS06060 (OQG81_06060) ciaR 1136358..1137032 (-) 675 WP_014294586.1 response regulator transcription factor Regulator
  OQG81_RS06065 (OQG81_06065) - 1137230..1139773 (-) 2544 WP_265644258.1 M1 family metallopeptidase -
  OQG81_RS06070 (OQG81_06070) - 1140074..1141330 (+) 1257 WP_014295262.1 ISL3 family transposase -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25525.27 Da        Isoelectric Point: 4.3477

>NTDB_id=762297 OQG81_RS06060 WP_014294586.1 1136358..1137032(-) (ciaR) [Streptococcus macedonicus strain E37]
MIKILLVEDDLSLSNSIFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKDGFQVLKELREKGVSTPVLIMTA
KESLGDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKYNFNTLSYEELTVDTSTNTTIANGKEVELLGKEFDLLVY
FLQNQNVILPKSQIFDRIWGFDSDTTISVVEVYVSKIRKKLKDTTFAKNLQTLRSVGYILKNVE

Nucleotide


Download         Length: 675 bp        

>NTDB_id=762297 OQG81_RS06060 WP_014294586.1 1136358..1137032(-) (ciaR) [Streptococcus macedonicus strain E37]
ATGATTAAGATATTATTAGTAGAGGATGATTTGAGTCTATCTAATTCCATTTTTGATTTTTTAGATGATTTTGCAGATGT
TATGCAGGTATTTGACGGCGAAGAAGGTTTGTACGAAGCTGAAAGTGGCGTATATGACCTTATTTTGCTTGACTTGATGT
TACCTGAAAAAGATGGTTTCCAAGTGCTTAAAGAGTTACGAGAAAAAGGTGTGTCAACACCAGTACTTATTATGACTGCC
AAAGAAAGTCTTGGTGATAAGGGACATGGTTTCGAGTTGGGAGCAGATGATTATCTTACTAAACCATTTTACCTTGAAGA
GCTAAAAATGCGTATTCAAGCTCTTTTAAAACGTTCGGGTAAATACAACTTCAATACCTTATCTTATGAAGAATTAACCG
TTGACACTTCTACCAATACAACAATAGCTAACGGTAAAGAAGTCGAGCTGCTTGGTAAAGAATTTGATTTGTTGGTTTAT
TTCTTACAAAATCAAAATGTTATTTTACCAAAATCACAAATTTTTGACCGTATTTGGGGCTTTGATAGTGATACAACGAT
TTCGGTTGTTGAAGTTTACGTTTCAAAAATTCGAAAAAAACTCAAAGACACCACCTTTGCCAAAAATCTTCAAACCCTAC
GGAGTGTAGGTTATATTCTGAAAAATGTTGAATAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)

Response regulator receiver domain (Response_reg)

(4-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A380K9T7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus mutans UA159

92.377

99.554

0.92
  ciaR Streptococcus pneumoniae Rx1

86.607

100

0.866
  ciaR Streptococcus pneumoniae D39

86.607

100

0.866
  ciaR Streptococcus pneumoniae R6

86.607

100

0.866
  ciaR Streptococcus pneumoniae TIGR4

86.607

100

0.866
  covR Lactococcus lactis subsp. lactis strain DGCC12653

38.938

100

0.393
  vicR Streptococcus mutans UA159

36.017

100

0.379
  micA Streptococcus pneumoniae Cp1015

35.193

100

0.366