Detailed information NTG0762296

Bioinformatically predicted

Overview

• Name: ciaH
• Type: Regulator
• Locus tag: OQG81_RS06055
• Genome accession: NZ_CP113440
• Coordinates: 1135028..1136368 (-)
• Length: 446 a.a.
• NCBI ID: WP_039670832.1
• Uniprot ID: A0A081JHE3
• Organism: Streptococcus macedonicus strain E37
• Function: Required for optimal comC expression (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
Genomic island	1133280..1141330	1135028..1136368	within	0
IS/Tn	1133280..1134443	1135028..1136368	flank	585

Gene organization within MGE regions

Location: 1133280..1141330

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
OQG81_RS06045 (OQG81_06045)	-	1133280..1134443 (-)	1164	WP_265631676.1	IS30 family transposase	-
OQG81_RS06050 (OQG81_06050)	rpsT	1134640..1134891 (+)	252	WP_081498578.1	30S ribosomal protein S20	-
OQG81_RS06055 (OQG81_06055)	ciaH	1135028..1136368 (-)	1341	WP_039670832.1	sensor histidine kinase	Regulator
OQG81_RS06060 (OQG81_06060)	ciaR	1136358..1137032 (-)	675	WP_014294586.1	response regulator transcription factor	Regulator
OQG81_RS06065 (OQG81_06065)	-	1137230..1139773 (-)	2544	WP_265644258.1	M1 family metallopeptidase	-
OQG81_RS06070 (OQG81_06070)	-	1140074..1141330 (+)	1257	WP_014295262.1	ISL3 family transposase	-

Sequence

Protein

• Length: 446 a.a.
• Molecular weight: 50231.14 Da
• Isoelectric Point: 6.2742

>NTDB_id=762296 OQG81_RS06055 WP_039670832.1 1135028..1136368(-) (ciaH) [Streptococcus macedonicus strain E37]
MLNKLQKKLSSGTFSHFFHFFAVFTGIFVIMTVIILQIMRYGLYSSVDTSLQNAADNANDYVVRTMERSDTLQSNDSPTD
TFSGGTSSSGKAKPSTSRVGLSNVSVLLYDEDGKILNALDAFVQFGTLSTTFDEGSVGEIKEQKITTIFGQTEKYHVLTV
KVSSSEYPSIKYATFLVSVRQLDEASERYVTITITVMVIFWIISVVASVYLANWTRKPIMESYEKQKTFVENASHELRTP
LTVLQNRLESLFRRPDATILDNSESIAASLDEVRNMRILTTNLLNLARRDDGLKVELEDIQPPTFNEIFENYDMIAEENG
KTFVGHNLVDRPIKSDRTLLKQLMTILFDNAIKYTDNDGVIEFTVKTTDKQTILTVADNGPGISDADKVKIFDRFYRVDK
ARTRQKGGFGLGLSLAKQIVDVLKGDIQVKDNQPKGTIFEVRFNRH

Nucleotide

• Length: 1341 bp

>NTDB_id=762296 OQG81_RS06055 WP_039670832.1 1135028..1136368(-) (ciaH) [Streptococcus macedonicus strain E37]
ATGTTGAATAAATTACAGAAAAAATTATCATCAGGGACATTTTCACATTTCTTCCATTTCTTTGCTGTCTTCACGGGAAT
TTTTGTCATCATGACAGTTATCATTTTGCAGATTATGCGCTATGGTCTTTATTCCTCTGTTGATACGAGTTTGCAAAATG
CAGCAGACAATGCCAATGATTATGTCGTGCGAACTATGGAACGTAGCGATACTTTGCAATCGAATGATTCTCCTACGGAC
ACTTTTTCAGGAGGAACAAGTAGTTCTGGGAAAGCGAAACCTAGTACCAGCAGAGTTGGTCTAAGTAACGTTAGCGTTCT
TCTTTATGATGAAGACGGTAAAATCTTAAATGCTTTGGATGCTTTTGTTCAATTTGGAACGTTATCGACAACTTTTGATG
AAGGTAGTGTCGGCGAAATCAAAGAACAGAAGATTACGACCATTTTTGGTCAAACCGAGAAATACCATGTGCTGACTGTA
AAAGTGAGTAGTAGCGAGTATCCTAGTATAAAATACGCTACTTTCCTTGTTAGTGTTCGTCAGTTAGATGAAGCTAGCGA
ACGATATGTAACAATTACGATCACTGTTATGGTTATTTTCTGGATTATTTCGGTCGTAGCAAGTGTTTATCTTGCCAATT
GGACAAGAAAACCAATTATGGAAAGCTATGAAAAACAAAAAACCTTTGTCGAAAATGCTAGTCATGAGTTGCGTACACCG
CTTACTGTTTTGCAGAATCGTTTAGAAAGTCTCTTTAGGCGACCTGATGCTACAATTTTGGATAATAGTGAAAGTATTGC
CGCCAGTTTAGACGAAGTTCGAAATATGCGAATTTTGACCACAAATCTGCTGAATTTGGCACGTCGTGATGATGGTTTGA
AAGTTGAGTTGGAGGATATTCAACCACCGACTTTCAATGAAATCTTTGAAAATTACGATATGATTGCTGAAGAAAATGGC
AAGACATTTGTCGGACATAATTTGGTAGACCGACCAATCAAATCAGATCGTACATTGTTAAAACAACTGATGACTATCTT
ATTTGATAATGCCATAAAATACACCGACAATGATGGTGTCATTGAATTTACCGTTAAAACAACAGACAAACAAACAATTC
TGACAGTTGCTGATAACGGTCCAGGAATTAGCGACGCTGATAAAGTTAAGATTTTTGACCGTTTTTATCGTGTGGATAAA
GCACGGACACGTCAAAAAGGCGGTTTTGGTCTAGGATTGTCACTTGCTAAGCAAATTGTTGACGTTTTAAAAGGCGATAT
TCAAGTCAAAGATAACCAACCAAAAGGAACTATTTTTGAAGTCCGTTTTAATCGTCATTAA

Domains

Predicted by InterproScan.

• His Kinase A (phospho-acceptor) domain (HisKA) (227-292)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (336-443)

3D structure

• AlphaFold DB: A0A081JHE3

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaH	Streptococcus mutans UA159	60.045	99.327	0.596
ciaH	Streptococcus pneumoniae Rx1	51.467	99.327	0.511
ciaH	Streptococcus pneumoniae D39	51.467	99.327	0.511
ciaH	Streptococcus pneumoniae R6	51.467	99.327	0.511
ciaH	Streptococcus pneumoniae TIGR4	51.467	99.327	0.511