Detailed information NTG0761467

Bioinformatically predicted

Overview

• Name: comEA/celA/cilE
• Type: Machinery gene
• Locus tag: OTB22_RS03605
• Genome accession: NZ_CP113267
• Coordinates: 710893..711543 (+)
• Length: 216 a.a.
• NCBI ID: WP_000387331.1
• Uniprot ID: A0A0E7VQD3
• Organism: Streptococcus pneumoniae strain BC2
• Function: dsDNA binding to the cell surface (predicted from homology) DNA binding and uptake

Genomic Context

Location: 705893..716543

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
OTB22_RS03575 (OTB22_03580)	pyrH	706617..707354 (+)	738	WP_000002997.1	UMP kinase	-
OTB22_RS03580 (OTB22_03585)	frr	707363..707920 (+)	558	WP_000024409.1	ribosome recycling factor	-
OTB22_RS03585 (OTB22_03590)	cvfB	707980..708834 (+)	855	WP_001095445.1	RNA-binding virulence regulatory protein CvfB	-
OTB22_RS03590 (OTB22_03595)	-	708843..709058 (+)	216	WP_001232082.1	YozE family protein	-
OTB22_RS03595 (OTB22_03600)	-	709144..710148 (+)	1005	WP_050096410.1	PhoH family protein	-
OTB22_RS03600 (OTB22_03605)	-	710256..710825 (+)	570	WP_000443751.1	GNAT family N-acetyltransferase	-
OTB22_RS03605 (OTB22_03610)	comEA/celA/cilE	710893..711543 (+)	651	WP_000387331.1	ComEA family DNA-binding protein	Machinery gene
OTB22_RS03610 (OTB22_03615)	comEC/celB	711527..713767 (+)	2241	WP_000942403.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
OTB22_RS03615 (OTB22_03620)	-	713946..714134 (+)	189	WP_001809102.1	hypothetical protein	-
OTB22_RS03620 (OTB22_03625)	-	714166..714753 (+)	588	WP_000933542.1	ATP-binding cassette domain-containing protein	-
OTB22_RS03625 (OTB22_03630)	-	714757..715938 (+)	1182	WP_000655958.1	ABC transporter permease	-

Sequence

Protein

• Length: 216 a.a.
• Molecular weight: 23203.57 Da
• Isoelectric Point: 5.5171

>NTDB_id=761467 OTB22_RS03605 WP_000387331.1 710893..711543(+) (comEA/celA/cilE) [Streptococcus pneumoniae strain BC2]
MEAIIEKIKEYKIIVICTGLGLLVGGFFLLKPAPQTPVKETNLQAEVAAVSKDLVSEKEVNKEEKEEPLEQDLITVDVKG
AVKSPGIYDLPVGSRVNDAVQKAGGLTEQADSKSLNLAQKVSDEALVYVPTKGEEAVSQQTGSGTASSISKEKKVNLNKA
SLEELKQVKGLGGKRAQDIIDHREANGKFKSVDELKKVSGIGGKTIEKLKDYVTVD

Nucleotide

• Length: 651 bp

>NTDB_id=761467 OTB22_RS03605 WP_000387331.1 710893..711543(+) (comEA/celA/cilE) [Streptococcus pneumoniae strain BC2]
ATGGAAGCAATTATCGAGAAAATCAAAGAGTATAAAATCATCGTCATCTGTACTGGTCTGGGCTTGCTTGTAGGCGGATT
TTTCCTGCTAAAGCCAGCTCCACAAACACCTGTAAAGGAAACGAATTTGCAGGCTGAAGTTGCAGCTGTTTCCAAGGATT
TGGTATCCGAAAAGGAAGTGAACAAGGAAGAGAAGGAAGAACCCCTTGAACAAGATCTAATCACAGTAGATGTCAAAGGT
GCTGTCAAATCGCCAGGGATTTATGACTTGCCTGTAGGTAGTCGAGTCAATGATGCTGTTCAGAAGGCTGGTGGCTTGAC
AGAGCAAGCAGACAGCAAGTCGCTCAATCTAGCTCAGAAAGTTAGTGATGAGGCTCTGGTTTACGTTCCTACTAAGGGAG
AAGAAGCAGTTAGTCAACAGACTGGTTCGGGGACAGCTTCTTCAATAAGCAAGGAAAAGAAGGTCAATCTCAACAAGGCC
AGTCTGGAAGAACTCAAGCAGGTCAAGGGACTGGGAGGAAAACGAGCTCAGGACATTATCGACCATCGTGAGGCAAATGG
CAAGTTCAAGTCAGTAGACGAGCTCAAGAAGGTCTCTGGCATTGGTGGCAAAACAATAGAAAAGCTTAAAGACTATGTTA
CAGTGGATTAA

Domains

Predicted by InterproScan.

• SLBB domain (SLBB) (76-126)

• Helix-hairpin-helix motif (HHH_3) (151-214)

3D structure

• AlphaFold DB: A0A0E7VQD3

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEA/celA/cilE	Streptococcus pneumoniae Rx1	99.537	100	0.995
comEA/celA/cilE	Streptococcus pneumoniae D39	99.537	100	0.995
comEA/celA/cilE	Streptococcus pneumoniae R6	99.537	100	0.995
comEA/celA/cilE	Streptococcus pneumoniae TIGR4	97.685	100	0.977
comEA/celA/cilE	Streptococcus mitis NCTC 12261	96.296	100	0.963
comEA/celA/cilE	Streptococcus mitis SK321	90.741	100	0.907
comEA	Lactococcus lactis subsp. cremoris KW2	43.612	100	0.458
comEA	Bacillus subtilis subsp. subtilis str. 168	41.579	87.963	0.366
comEA	Latilactobacillus sakei subsp. sakei 23K	33.476	100	0.361