Detailed information NTG0075362

Bioinformatically predicted

Overview

• Name: dprA/cilB/dalA
• Type: Machinery gene
• Locus tag: UKS_RS06075
• Genome accession: NZ_AP021887
• Coordinates: 1185391..1186239 (-)
• Length: 282 a.a.
• NCBI ID: WP_156012204.1
• Uniprot ID: A0A6H3SJQ2
• Organism: Streptococcus sp. 116-D4
• Function: ssDNA binding; loading RecA onto ssDNA; competence shut-off (predicted from homology) DNA processing Competence regulation

Genomic Context

Location: 1180391..1191239

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
UKS_RS06055 (UKS_11590)	-	1180991..1181647 (-)	657	WP_156012201.1	MmcQ/YjbR family DNA-binding protein	-
UKS_RS06060 (UKS_11600)	-	1181691..1182323 (-)	633	WP_049494811.1	copper homeostasis protein CutC	-
UKS_RS06065 (UKS_11610)	-	1182416..1182775 (-)	360	WP_156012202.1	YbaN family protein	-
UKS_RS06070 (UKS_11620)	topA	1183034..1185121 (-)	2088	WP_156012203.1	type I DNA topoisomerase	-
UKS_RS06075 (UKS_11640)	dprA/cilB/dalA	1185391..1186239 (-)	849	WP_156012204.1	DNA-processing protein DprA	Machinery gene
UKS_RS06080 (UKS_11650)	-	1186327..1187016 (-)	690	WP_156012205.1	sugar phosphate nucleotidyltransferase	-
UKS_RS06085 (UKS_11660)	-	1187028..1187906 (-)	879	WP_049494818.1	DMT family transporter	-
UKS_RS06090 (UKS_11670)	-	1187896..1188765 (-)	870	WP_156012206.1	phosphotransferase family protein	-
UKS_RS06095 (UKS_11680)	-	1188782..1189804 (-)	1023	WP_156012207.1	ribitol-5-phosphate dehydrogenase	-
UKS_RS06100 (UKS_11690)	-	1189809..1190516 (-)	708	WP_000638495.1	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-

Sequence

Protein

• Length: 282 a.a.
• Molecular weight: 31160.82 Da
• Isoelectric Point: 5.0590

>NTDB_id=75362 UKS_RS06075 WP_156012204.1 1185391..1186239(-) (dprA/cilB/dalA) [Streptococcus sp. 116-D4]
MKITNYEIYKLKKSGLTNQQILKVLEYGENVDQELLLGDIADISGCRNPAVFMERYFQIDDAHLEKEFQKFPSFSILDDC
YPWDLSEIYDAPVLLFYKGNLDLLKFPKVAVVGSRACSKQGAKSVEKVIQGLENELVIVSGLAKGIDTSAHMAALQNGGK
TIAVIGTGLDVFYPKANKRLQDYIGNDHLILSEYGPGEQPLKFHFPARNRIIAGLCRGVIVAEAKMRSGSLITCERAMEE
GRDVFAIPGSILDGLSDGCHYLIQEGAKLVTSGQDVLAEFEF

Nucleotide

• Length: 849 bp

>NTDB_id=75362 UKS_RS06075 WP_156012204.1 1185391..1186239(-) (dprA/cilB/dalA) [Streptococcus sp. 116-D4]
ATGAAAATCACAAACTATGAAATCTATAAGTTAAAAAAATCAGGTTTGACCAATCAACAAATTTTGAAAGTTTTAGAATA
CGGTGAAAATGTTGATCAGGAGCTTTTGTTGGGTGATATTGCAGATATATCAGGTTGCCGAAATCCAGCTGTTTTTATGG
AACGTTATTTTCAGATAGACGATGCGCATTTGGAGAAGGAGTTTCAAAAATTTCCATCATTCTCTATTTTAGACGACTGT
TACCCTTGGGATTTGAGTGAAATATATGATGCACCTGTGCTGTTATTTTACAAGGGGAATTTGGATCTCTTGAAATTTCC
TAAGGTAGCGGTAGTGGGAAGTCGTGCTTGTAGTAAACAGGGAGCTAAGTCAGTTGAAAAAGTCATTCAAGGCTTGGAAA
ATGAACTGGTTATCGTCAGTGGCTTAGCCAAGGGGATTGACACATCAGCTCATATGGCAGCTCTTCAGAATGGCGGAAAA
ACCATTGCAGTGATTGGAACAGGTCTGGACGTGTTTTATCCTAAAGCCAATAAACGCTTGCAAGACTACATTGGCAATGA
TCATCTGATTCTCAGTGAGTACGGACCAGGCGAACAACCTCTGAAATTTCATTTTCCTGCCCGTAATCGCATCATCGCTG
GACTTTGTCGTGGTGTGATTGTAGCAGAGGCCAAGATGCGCTCGGGGAGTCTCATTACCTGTGAGAGAGCAATGGAAGAA
GGACGCGATGTTTTTGCTATTCCTGGAAGTATTTTAGATGGACTATCAGACGGTTGCCATTATTTGATTCAAGAAGGGGC
AAAATTAGTCACCAGTGGGCAAGATGTGCTTGCGGAATTTGAATTTTAA

Domains

Predicted by InterproScan.

• DNA recombination-mediator protein A (DNA_processg_A) (75-271)

• DNA processing protein A sterile alpha motif domain (SAM_DprA) (3-64)

3D structure

• AlphaFold DB: A0A6H3SJQ2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
dprA/cilB/dalA	Streptococcus pneumoniae Rx1	98.582	100	0.986
dprA/cilB/dalA	Streptococcus pneumoniae D39	98.582	100	0.986
dprA/cilB/dalA	Streptococcus pneumoniae R6	98.582	100	0.986
dprA/cilB/dalA	Streptococcus pneumoniae TIGR4	98.582	100	0.986
dprA/cilB/dalA	Streptococcus mitis NCTC 12261	97.872	100	0.979
dprA/cilB/dalA	Streptococcus mitis SK321	97.163	100	0.972
dprA	Streptococcus mutans UA159	62.5	99.291	0.621
dprA	Lactococcus lactis subsp. cremoris KW2	54.643	99.291	0.543
dprA	Staphylococcus aureus N315	37.456	100	0.376
dprA	Haemophilus influenzae Rd KW20	38.202	94.681	0.362