Detailed information NTG0074542

Bioinformatically predicted

Overview

• Name: vicR
• Type: Regulator
• Locus tag: SAGCMC97051_RS04450
• Genome accession: NZ_AP020310
• Coordinates: 793874..794584 (+)
• Length: 236 a.a.
• NCBI ID: WP_000722052.1
• Uniprot ID: X5K3L1
• Organism: Streptococcus agalactiae strain GCMC97051
• Function: repress comCDE expression; repress comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 788874..799584

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SAGCMC97051_RS04420 (SAGCMC97051_07940)	-	789392..789976 (+)	585	WP_000666016.1	hypothetical protein	-
SAGCMC97051_RS04425 (SAGCMC97051_07950)	-	790115..790933 (+)	819	WP_000701734.1	ParA family protein	-
SAGCMC97051_RS04430 (SAGCMC97051_07960)	-	790933..791211 (+)	279	WP_001282887.1	hypothetical protein	-
SAGCMC97051_RS04435 (SAGCMC97051_07970)	-	791223..791618 (+)	396	WP_000323826.1	replication initiator protein A	-
SAGCMC97051_RS04440 (SAGCMC97051_07980)	-	791615..791929 (+)	315	WP_000583308.1	hypothetical protein	-
SAGCMC97051_RS04445 (SAGCMC97051_07990)	-	792068..793393 (+)	1326	WP_000459145.1	ISLre2 family transposase	-
SAGCMC97051_RS04450 (SAGCMC97051_08000)	vicR	793874..794584 (+)	711	WP_000722052.1	response regulator YycF	Regulator
SAGCMC97051_RS04455 (SAGCMC97051_08010)	vicK	794577..795926 (+)	1350	WP_001065469.1	cell wall metabolism sensor histidine kinase VicK	Regulator
SAGCMC97051_RS04460 (SAGCMC97051_08020)	vicX	795930..796739 (+)	810	WP_001289497.1	MBL fold metallo-hydrolase	Regulator
SAGCMC97051_RS04465 (SAGCMC97051_08030)	-	796742..797110 (+)	369	WP_000719384.1	YbaN family protein	-
SAGCMC97051_RS04470 (SAGCMC97051_08040)	rnc	797286..797972 (+)	687	WP_000661526.1	ribonuclease III	-

Sequence

Protein

• Length: 236 a.a.
• Molecular weight: 27063.90 Da
• Isoelectric Point: 4.8246

>NTDB_id=74542 SAGCMC97051_RS04450 WP_000722052.1 793874..794584(+) (vicR) [Streptococcus agalactiae strain GCMC97051]
MKKILIVDDEKPISDIIKFNLTKEGYETATAFDGREALVQYAEFQPDLIILDLMLPELDGLEVAKEVRKTSHIPIIMLSA
KDSEFDKVIGLEIGADDYVTKPFSNRELLARVKAHLRRTENIETAVAEESAQNASSDITIGELQILPDAFIAKKRGEEIE
LTHREFELLHHLATHIGQVMTREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPGRPEYILTRRGVGYYMKSYE

Nucleotide

• Length: 711 bp

>NTDB_id=74542 SAGCMC97051_RS04450 WP_000722052.1 793874..794584(+) (vicR) [Streptococcus agalactiae strain GCMC97051]
ATGAAAAAAATACTTATCGTTGATGATGAAAAACCAATTTCAGATATTATCAAATTTAATTTAACCAAAGAAGGATATGA
GACGGCGACAGCTTTCGATGGCCGTGAAGCTTTAGTACAATATGCAGAATTTCAACCAGATTTAATCATTTTGGATTTAA
TGCTTCCTGAACTAGATGGTTTAGAAGTGGCTAAGGAAGTTCGTAAAACCAGCCATATTCCTATTATTATGCTTTCTGCA
AAAGACAGTGAGTTTGACAAAGTCATTGGTTTAGAAATCGGTGCAGATGATTATGTTACTAAACCTTTTTCAAATCGTGA
ACTTTTGGCACGGGTCAAAGCACATTTACGACGTACTGAAAATATTGAAACAGCTGTAGCAGAAGAAAGTGCTCAAAATG
CTTCTTCAGATATTACTATTGGTGAGTTGCAAATTTTACCAGATGCCTTTATTGCTAAGAAACGTGGCGAAGAAATTGAA
TTAACGCACCGAGAATTTGAATTACTTCACCATTTAGCGACACATATCGGACAAGTCATGACACGCGAACATTTATTGGA
AACAGTTTGGGGATATGATTATTTTGGAGATGTCCGTACAGTTGATGTGACGGTGAGACGTTTACGTGAAAAGATTGAAG
ATACTCCTGGTCGTCCAGAATATATTTTGACTCGACGTGGTGTAGGTTATTACATGAAGTCTTATGAATAA

Domains

Predicted by InterproScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (156-231)

• Response regulator receiver domain (Response_reg) (4-113)

3D structure

• AlphaFold DB: X5K3L1

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vicR	Streptococcus mutans UA159	88.983	100	0.89
micA	Streptococcus pneumoniae Cp1015	77.778	99.153	0.771
covR	Lactococcus lactis subsp. lactis strain DGCC12653	46.983	98.305	0.462
covR	Streptococcus salivarius strain HSISS4	44.635	98.729	0.441
scnR	Streptococcus mutans UA159	38.559	100	0.386