Detailed information NTG0725441

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: PY824_RS07635
• Genome accession: NZ_CP119172
• Coordinates: 1448053..1450206 (+)
• Length: 717 a.a.
• NCBI ID: WP_115265876.1
• Uniprot ID: -
• Organism: Streptococcus macedonicus strain SGM CIP105683
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 1443053..1455206

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
PY824_RS07600 (PY824_07600)	-	1443194..1443385 (-)	192	WP_039671029.1	Blp family class II bacteriocin	-
PY824_RS07605 (PY824_07605)	-	1444066..1444257 (-)	192	WP_024405076.1	hypothetical protein	-
PY824_RS07610 (PY824_07610)	-	1444259..1444489 (-)	231	WP_115265875.1	bacteriocin class II family protein	-
PY824_RS07615 (PY824_07615)	-	1445180..1446284 (+)	1105	Protein_1436	IS3 family transposase	-
PY824_RS07620 (PY824_07620)	-	1446486..1446770 (+)	285	Protein_1437	transposase	-
PY824_RS07625 (PY824_07625)	-	1447284..1447487 (-)	204	WP_039671032.1	Blp family class II bacteriocin	-
PY824_RS07630 (PY824_07630)	-	1447502..1447756 (-)	255	WP_039671033.1	Blp family class II bacteriocin	-
PY824_RS07635 (PY824_07635)	comA/nlmT	1448053..1450206 (+)	2154	WP_115265876.1	peptide cleavage/export ABC transporter	Regulator
PY824_RS07640 (PY824_07640)	comB	1450218..1451579 (+)	1362	WP_115265877.1	bacteriocin secretion accessory protein	Regulator
PY824_RS07645 (PY824_07645)	-	1451678..1451833 (+)	156	WP_096811960.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
PY824_RS07650 (PY824_07650)	-	1451881..1453221 (-)	1341	WP_039671036.1	sensor histidine kinase	-
PY824_RS07655 (PY824_07655)	comE/blpR	1453232..1453972 (-)	741	WP_096811959.1	response regulator transcription factor	Regulator
PY824_RS07660 (PY824_07660)	-	1453974..1454315 (-)	342	WP_024404826.1	LytTR family DNA-binding domain-containing protein	-

Sequence

Protein

• Length: 717 a.a.
• Molecular weight: 80549.52 Da
• Isoelectric Point: 7.6433

>NTDB_id=725441 PY824_RS07635 WP_115265876.1 1448053..1450206(+) (comA/nlmT) [Streptococcus macedonicus strain SGM CIP105683]
MTSYKRTFVPQIDARDCGVAALASIAKFYGSDYSLAHLRELAKTNKEGTIALGIVKAAQEIGFETRAIQADMSLFDMNDV
PYPFIVHVNKEGKLQHYYVVYHNKKDHLIIGDPDPTVKVTKMTKERFASEWTGVAIFLAPEPSYKPHKDKKNGLMSFLPL
IFRQRALIFYIVLASLLVTLINIGGSYYLQGILDEYIPNQMKSTLGIISIGLIITYILQQMMSFSRDYLLTVLSQRLSID
VILSYIRHIFELPMSFFATRRTGEVISRFTDANSIIDALASTILSLFLDVSILTIVGGVLLVQNTNLFLLSLISVPIYII
IIFAFMKPFEKMNNDVMQSNSMVSSAIIEDINGIETIKSLTSEESRYQKIDSEFVDYLDKSFKLSKYSILQTTLKQGAQL
ILNIVILWFGAQLVMNGHISVGQLITFNTLLSYFTNPLENIINLQTKLQSAKVANNRLNEVYLVESELSNNQTLTDSQFL
TGDIRFEDLSYKYGFGRDTLSDINLTIKQGDKVSLVGISGSGKTTLAKMIVNFFEPYKGRITINNNDLKLIDKKTLRQHI
NYLPQQAYIFSGSILENLTLGANQLISQEDIIRACEIAEIRQDIEQMPMGYQTELSDGAGLSGGQKQRIALARALLTKAP
VLILDEATSGLDVLTEKKVIDNLMAMADKTIIFVAHRLSISERTNQVIVLDQGKVIETGSHHKLMTKQGFYHHLFSK

Nucleotide

• Length: 2154 bp

>NTDB_id=725441 PY824_RS07635 WP_115265876.1 1448053..1450206(+) (comA/nlmT) [Streptococcus macedonicus strain SGM CIP105683]
ATGACCTCTTATAAACGAACCTTTGTTCCTCAAATTGATGCCAGAGACTGTGGTGTAGCTGCTTTAGCTTCTATTGCCAA
GTTTTACGGTTCTGACTATTCTCTAGCTCATTTGAGAGAATTAGCCAAAACTAACAAGGAAGGAACAATCGCACTTGGTA
TCGTTAAAGCTGCCCAAGAAATAGGCTTTGAGACAAGAGCCATCCAAGCTGATATGAGCCTTTTTGATATGAATGATGTC
CCTTACCCTTTCATCGTTCACGTCAATAAAGAAGGAAAGCTCCAACACTACTATGTGGTCTATCACAACAAAAAAGACCA
CCTCATCATTGGTGATCCTGACCCTACGGTCAAAGTCACCAAGATGACCAAGGAGCGGTTTGCTTCTGAATGGACAGGCG
TTGCTATCTTTCTGGCTCCAGAACCCAGCTATAAGCCTCACAAAGATAAAAAGAACGGCCTGATGAGCTTTCTCCCTCTT
ATTTTCAGGCAACGTGCGCTTATCTTTTATATCGTCTTGGCTAGCCTTTTGGTGACACTTATCAATATTGGTGGTTCTTA
CTACCTGCAAGGGATTTTGGATGAATACATTCCTAATCAAATGAAGTCAACCTTGGGGATTATCTCCATCGGCCTGATTA
TCACCTACATCCTCCAGCAGATGATGAGTTTCTCACGAGATTACCTTTTGACTGTGCTCAGCCAGCGGCTAAGCATTGAT
GTGATTCTTTCCTATATCCGTCATATCTTTGAACTGCCCATGTCCTTTTTTGCGACACGGCGGACTGGTGAGGTTATCTC
TCGCTTTACAGATGCCAATTCAATCATTGATGCCCTGGCATCGACCATTTTGTCACTCTTCCTTGATGTCTCTATTTTAA
CCATCGTCGGTGGTGTGCTTTTGGTACAAAACACCAACCTCTTCCTGCTCTCCTTGATTTCAGTTCCCATTTACATCATC
ATTATTTTTGCTTTTATGAAGCCGTTTGAGAAGATGAATAACGATGTGATGCAGAGCAATTCCATGGTCAGCTCTGCCAT
TATCGAAGACATCAACGGCATTGAAACCATCAAATCCTTGACCAGTGAAGAAAGCCGCTACCAGAAGATTGATAGCGAGT
TCGTAGATTACCTGGACAAATCCTTCAAACTCAGTAAATACTCTATCCTGCAAACTACCCTTAAACAGGGAGCTCAGCTC
ATTCTAAATATTGTCATCTTGTGGTTTGGGGCCCAGCTAGTCATGAACGGACACATTTCAGTTGGACAACTGATCACCTT
CAACACCCTTCTATCTTATTTTACCAATCCTTTAGAAAATATTATAAACCTCCAAACCAAGCTCCAGTCTGCCAAGGTGG
CTAACAATCGCCTGAATGAAGTCTACCTGGTTGAATCTGAACTCAGTAACAATCAGACCTTAACAGATTCACAGTTCCTG
ACTGGCGATATTCGCTTTGAAGACCTTTCCTATAAGTACGGTTTCGGACGTGACACCCTATCGGATATCAATCTGACCAT
CAAACAAGGCGATAAGGTCAGTCTAGTGGGAATTAGCGGCTCAGGAAAAACAACCTTGGCCAAGATGATTGTCAATTTCT
TTGAGCCTTACAAGGGTCGAATCACCATCAACAACAATGACCTTAAACTAATTGATAAAAAGACGCTTCGGCAACACATT
AACTACCTCCCACAACAAGCTTATATCTTCAGTGGCTCAATCTTAGAAAACTTGACTTTAGGGGCTAATCAACTGATTAG
TCAGGAAGATATTATCAGAGCTTGTGAGATCGCTGAAATTCGACAAGACATCGAGCAGATGCCTATGGGCTATCAAACAG
AATTGTCTGACGGAGCTGGCTTATCGGGTGGTCAAAAGCAACGGATTGCTTTGGCTAGGGCTCTACTGACTAAAGCCCCT
GTTCTTATTCTTGATGAAGCAACTAGCGGCCTTGATGTGCTAACGGAGAAAAAGGTCATTGATAATTTAATGGCCATGGC
AGACAAGACCATTATCTTTGTCGCACACCGCCTCAGTATTTCTGAGCGAACCAACCAAGTTATCGTTCTTGACCAAGGGA
AGGTCATTGAGACTGGTTCACATCACAAATTGATGACCAAACAAGGTTTCTACCATCATCTATTTAGCAAGTAA

Domains

Predicted by InterProScan.

• Peptidase C39 family (Peptidase_C39) (7-142)

• ABC transporter (ABC_tran) (500-649)

• ABC transporter transmembrane region (ABC_membrane) (168-438)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	73.566	99.721	0.734
comA	Streptococcus mitis NCTC 12261	68.354	99.163	0.678
comA	Streptococcus mitis SK321	67.792	99.163	0.672
comA	Streptococcus pneumoniae Rx1	67.651	99.163	0.671
comA	Streptococcus pneumoniae D39	67.651	99.163	0.671
comA	Streptococcus pneumoniae R6	67.651	99.163	0.671
comA	Streptococcus pneumoniae TIGR4	67.37	99.163	0.668
comA	Streptococcus gordonii str. Challis substr. CH1	65.315	99.721	0.651