Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   NWE23_RS04745 Genome accession   NZ_CP102746
Coordinates   970998..971669 (-) Length   223 a.a.
NCBI ID   WP_009909965.1    Uniprot ID   A0A075SH40
Organism   Streptococcus suis strain Transconjugant cAKJ47-2     
Function   repress competence development (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
IScluster/Tn 967188..973830 970998..971669 within 0


Gene organization within MGE regions


Location: 967188..973830
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  NWE23_RS04730 (NWE23_04740) tnpA 967188..967652 (-) 465 WP_012775157.1 IS200/IS605-like element ISSsu4 family transposase -
  NWE23_RS04735 (NWE23_04745) - 968066..969295 (-) 1230 WP_012027071.1 transglutaminase domain-containing protein -
  NWE23_RS04740 (NWE23_04750) ciaH 969626..971005 (-) 1380 WP_012027074.1 HAMP domain-containing sensor histidine kinase Regulator
  NWE23_RS04745 (NWE23_04755) ciaR 970998..971669 (-) 672 WP_009909965.1 response regulator transcription factor Regulator
  NWE23_RS04750 (NWE23_04760) - 971863..972243 (-) 381 WP_012027076.1 hypothetical protein -
  NWE23_RS04755 (NWE23_04765) - 972628..973830 (+) 1203 WP_012775158.1 IS110 family transposase -

Sequence

Protein


Download         Length: 223 a.a.        Molecular weight: 25290.00 Da        Isoelectric Point: 4.2183

>NTDB_id=718646 NWE23_RS04745 WP_009909965.1 970998..971669(-) (ciaR) [Streptococcus suis strain Transconjugant cAKJ47-2]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGEEGVYEAETGVYDLILLDLMLPEKDGFQVLKELREKGVTTPVLITTA
KESLEDKGHGFELGADDYLTKPFYLEELKMRIQALLKRAGKFNENTLTFGDVTVDLSTNMTMVNGEEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRIWGFDSDTTISVVEVYVSKIRKKLKGTTFGENLQTLRSVGYILKNA

Nucleotide


Download         Length: 672 bp        

>NTDB_id=718646 NWE23_RS04745 WP_009909965.1 970998..971669(-) (ciaR) [Streptococcus suis strain Transconjugant cAKJ47-2]
ATGATTAAAATATTGTTAGTGGAAGATGATTTAAGTCTATCAAATTCTGTTTTCGATTTCTTAGATGATTTTGCGGATGT
TATGCAGGTTTTTGATGGTGAAGAGGGCGTTTATGAGGCGGAAACAGGCGTTTATGATTTGATTCTTTTGGATTTAATGT
TACCTGAAAAAGACGGCTTTCAAGTCTTGAAAGAGTTACGTGAAAAGGGGGTTACGACACCAGTTCTGATTACAACAGCC
AAGGAAAGTCTAGAGGATAAAGGCCATGGTTTTGAATTGGGGGCTGATGACTATTTGACAAAACCGTTTTATTTAGAAGA
ATTGAAGATGCGAATTCAAGCTCTATTAAAACGAGCGGGTAAGTTTAATGAAAACACACTAACCTTTGGAGATGTGACAG
TTGACCTATCTACAAATATGACGATGGTAAATGGCGAAGAAGTTGAACTGTTAGGAAAAGAATTTGATCTACTAGTTTAT
TTCTTGCAAAATCAAAATGTTATTTTGCCAAAAACACAAATTTTTGACCGTATTTGGGGCTTTGACAGTGATACTACAAT
TTCAGTAGTAGAGGTATATGTTTCTAAAATTAGGAAAAAGTTGAAAGGAACGACTTTTGGGGAAAATCTTCAAACCCTGC
GTAGTGTCGGGTACATTCTAAAAAATGCCTAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A075SH40

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus mutans UA159

90.135

100

0.901
  ciaR Streptococcus pneumoniae Rx1

88.341

100

0.883
  ciaR Streptococcus pneumoniae D39

88.341

100

0.883
  ciaR Streptococcus pneumoniae R6

88.341

100

0.883
  ciaR Streptococcus pneumoniae TIGR4

88.341

100

0.883
  covR Lactococcus lactis subsp. lactis strain DGCC12653

38.496

100

0.39
  vicR Streptococcus mutans UA159

35.47

100

0.372
  covR Streptococcus salivarius strain HSISS4

35.841

100

0.363