Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   NWE23_RS04740 Genome accession   NZ_CP102746
Coordinates   969626..971005 (-) Length   459 a.a.
NCBI ID   WP_012027074.1    Uniprot ID   -
Organism   Streptococcus suis strain Transconjugant cAKJ47-2     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
IScluster/Tn 967188..973830 969626..971005 within 0


Gene organization within MGE regions


Location: 967188..973830
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  NWE23_RS04730 (NWE23_04740) tnpA 967188..967652 (-) 465 WP_012775157.1 IS200/IS605-like element ISSsu4 family transposase -
  NWE23_RS04735 (NWE23_04745) - 968066..969295 (-) 1230 WP_012027071.1 transglutaminase domain-containing protein -
  NWE23_RS04740 (NWE23_04750) ciaH 969626..971005 (-) 1380 WP_012027074.1 HAMP domain-containing sensor histidine kinase Regulator
  NWE23_RS04745 (NWE23_04755) ciaR 970998..971669 (-) 672 WP_009909965.1 response regulator transcription factor Regulator
  NWE23_RS04750 (NWE23_04760) - 971863..972243 (-) 381 WP_012027076.1 hypothetical protein -
  NWE23_RS04755 (NWE23_04765) - 972628..973830 (+) 1203 WP_012775158.1 IS110 family transposase -

Sequence

Protein


Download         Length: 459 a.a.        Molecular weight: 51955.61 Da        Isoelectric Point: 5.5984

>NTDB_id=718645 NWE23_RS04740 WP_012027074.1 969626..971005(-) (ciaH) [Streptococcus suis strain Transconjugant cAKJ47-2]
MPKRIGKLVYTDKFSFFIRYFAVFTLIFGLMTAIIFQLMRSTMYQNSDNTLKRIKEEPAMAVGFAIARTYEPNSVFILQD
SPTSEETTSSSSDSMPVPKEQKNTRDGDQLRLGVNTHVLLYSKSGEMVNPDTFTGLANLPLDKEKLGEIKETTVESSFGM
SEDYRYITIGLATDELGYYSSYDIKYATILVNVSQIKSSIESYESTVAIVMVSAWLISILASIYLSNLSMRPILISYQKQ
KDFVENASHELRTPLAVLQNRLESLFRHPETTILESSESIGSSLEEVRNMRLLTTNLLNLARRDDGLKVDMIDVQPNYFD
EIFANYLMIAEENGKTLTVNNLIHQPIRTDKVLIKQLLTILFDNAMKYTDDDGTIQIAANIKDKLVCFTVIDNGLGISDV
DKKKIFDRFYRVDKARTRQKGGFGLGLSLAQQIIKNLDGEISVRDNQPKGTIFEVRLPK

Nucleotide


Download         Length: 1380 bp        

>NTDB_id=718645 NWE23_RS04740 WP_012027074.1 969626..971005(-) (ciaH) [Streptococcus suis strain Transconjugant cAKJ47-2]
ATGCCTAAGCGAATCGGAAAATTAGTGTATACGGATAAATTTTCCTTCTTTATCCGTTATTTTGCAGTATTTACCCTGAT
TTTTGGCTTGATGACAGCTATCATTTTTCAATTAATGCGTTCAACTATGTATCAAAATTCAGATAATACCTTGAAACGGA
TTAAGGAAGAACCAGCGATGGCTGTTGGTTTTGCGATCGCAAGAACCTATGAGCCCAACTCTGTCTTTATACTTCAAGAT
AGCCCAACTAGTGAAGAAACGACGAGCTCTAGCTCAGATAGCATGCCTGTTCCTAAAGAACAAAAAAATACTAGAGATGG
AGATCAGCTGAGATTAGGTGTCAATACTCATGTCTTACTCTATAGTAAAAGTGGAGAAATGGTCAATCCGGATACTTTTA
CTGGTTTGGCCAACCTACCGTTAGATAAGGAAAAATTGGGTGAAATTAAGGAAACTACGGTTGAATCAAGTTTTGGTATG
TCTGAAGATTATCGCTATATAACGATTGGGCTGGCTACAGATGAACTAGGTTATTATTCGTCCTATGATATAAAATATGC
GACAATTTTGGTGAATGTCAGCCAAATTAAATCTTCCATTGAGAGCTATGAATCGACAGTTGCTATTGTTATGGTATCAG
CTTGGTTGATTTCTATACTAGCAAGTATTTACCTATCGAATCTTAGCATGCGTCCAATCCTAATTAGTTATCAAAAACAA
AAAGACTTCGTTGAAAATGCTAGTCATGAGTTACGCACACCGTTGGCAGTTCTTCAAAATCGCCTGGAAAGTCTATTTCG
TCATCCCGAGACAACTATTTTGGAAAGTAGTGAAAGCATCGGATCTAGTTTAGAAGAAGTTCGAAATATGCGACTATTAA
CAACGAACTTGCTCAATTTGGCTCGTCGTGATGATGGCTTAAAAGTCGATATGATCGATGTCCAACCCAACTATTTTGAT
GAAATCTTTGCTAATTACCTTATGATTGCCGAAGAAAATGGAAAAACTCTAACAGTTAATAATTTGATTCATCAGCCAAT
TCGAACAGACAAGGTTTTGATTAAACAGTTGCTCACCATTTTGTTTGACAACGCTATGAAGTATACCGATGATGATGGGA
CAATTCAAATAGCAGCTAATATCAAGGACAAACTAGTTTGTTTTACAGTTATTGACAATGGTTTGGGAATCAGCGATGTC
GATAAAAAGAAAATCTTTGATCGCTTTTACCGAGTTGACAAGGCTAGAACACGTCAAAAAGGTGGATTTGGTTTAGGTTT
ATCTTTAGCTCAACAAATTATTAAGAATCTAGATGGTGAGATTTCTGTGAGAGATAACCAACCGAAAGGAACTATTTTTG
AGGTACGTTTACCCAAATAA

Domains

Predicted by InterproScan.

His Kinase A (phospho-acceptor) domain (HisKA)

(240-306)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(350-458)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

49.237

100

0.492
  ciaH Streptococcus pneumoniae D39

49.237

100

0.492
  ciaH Streptococcus pneumoniae R6

49.237

100

0.492
  ciaH Streptococcus pneumoniae TIGR4

49.237

100

0.492
  ciaH Streptococcus mutans UA159

49.664

97.386

0.484