Detailed information NTG0071845

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: EL277_RS12655
• Genome accession: NZ_AP018936
• Coordinates: 516367..516954 (-)
• Length: 195 a.a.
• NCBI ID: WP_000205166.1
• Uniprot ID: Q9ETN5
• Organism: Streptococcus pneumoniae strain NU83127
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 511367..521954

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EL277_RS02680 (SPNU_0504)	-	511839..513168 (+)	1330	Protein_503	sensor histidine kinase	-
EL277_RS02685 (SPNU_0505)	blpC	513212..513367 (-)	156	WP_000358811.1	quorum-sensing system pheromone BlpC	-
EL277_RS02690 (SPNU_0506)	-	513424..514785 (-)	1362	WP_001069103.1	bacteriocin secretion accessory protein	-
EL277_RS12645 (SPNU_0507)	comA/nlmT	514796..515707 (-)	912	WP_001827226.1	ATP-binding cassette domain-containing protein	Regulator
EL277_RS12650 (SPNU_0508)	comA/nlmT	515697..516422 (-)	726	WP_167750760.1	ABC transporter transmembrane domain-containing protein	Regulator
EL277_RS12655 (SPNU_0509)	comA/nlmT	516367..516954 (-)	588	WP_000205166.1	cysteine peptidase family C39 domain-containing protein	Regulator
EL277_RS02705 (SPNU_0510)	-	517236..517439 (+)	204	WP_001093262.1	bacteriocin class II family protein	-
EL277_RS02710 (SPNU_0511)	-	517757..517960 (+)	204	WP_000411016.1	hypothetical protein	-
EL277_RS02720	-	518963..519767 (+)	805	Protein_511	IS5 family transposase	-
EL277_RS02725 (SPNU_0515)	blpM	519917..520171 (+)	255	WP_000379879.1	two-peptide bacteriocin subunit BlpM	-
EL277_RS02730 (SPNU_0516)	blpN	520187..520390 (+)	204	WP_001099492.1	two-peptide bacteriocin subunit BlpN	-
EL277_RS02740 (SPNU_0517)	cipB	520634..520783 (+)	150	WP_001818346.1	bacteriocin-like peptide BlpO	Regulator
EL277_RS02745	-	520887..521006 (+)	120	WP_000346296.1	PncF family bacteriocin immunity protein	-
EL277_RS12660	-	521516..521709 (+)	194	Protein_516	hypothetical protein	-

Sequence

Protein

• Length: 195 a.a.
• Molecular weight: 22270.71 Da
• Isoelectric Point: 9.6188

>NTDB_id=71845 EL277_RS12655 WP_000205166.1 516367..516954(-) (comA/nlmT) [Streptococcus pneumoniae strain NU83127]
MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKTNKEGTTALGIVKAADEMGFETRPVQADKTLFDMSDV
PYPFIVHVNKEGKLQHYYVVYQTKKDYLIIGDPDPSVKITKMSKERFFYEWTGVAIFLATKPSYQPHKDKKNGLLSKLPS
SDFQTKISHCLHCSLKLIGHYYQYRWFLLSPRNLG

Nucleotide

• Length: 588 bp

>NTDB_id=71845 EL277_RS12655 WP_000205166.1 516367..516954(-) (comA/nlmT) [Streptococcus pneumoniae strain NU83127]
ATGACTTCTTATAAACGTACATTTGTTCCTCAAATAGATGCGAGAGACTGTGGTGTCGCTGCCTTAGCCTCGATTGCTAA
ATTCTATGGTTCAGATTTTTCTCTAGCTCACTTGAGAGAACTTGCAAAGACCAATAAAGAAGGGACGACTGCTCTTGGCA
TTGTAAAAGCCGCTGATGAAATGGGCTTTGAAACAAGACCTGTTCAAGCAGATAAAACGCTCTTTGACATGAGTGATGTC
CCCTATCCATTTATCGTTCACGTTAACAAAGAAGGAAAACTCCAACATTACTATGTTGTCTATCAAACAAAGAAAGACTA
TCTGATTATTGGTGATCCTGACCCTTCTGTAAAAATCACTAAAATGTCAAAAGAACGCTTTTTCTATGAATGGACTGGAG
TAGCTATTTTTCTAGCTACCAAACCCAGCTATCAACCCCATAAAGATAAAAAGAATGGTCTACTAAGCAAGCTTCCTTCC
TCTGATTTTCAAACAAAAATCTCTCATTGCTTACATTGTTCTCTCAAGCTTATTGGTCACTATTATCAATATAGGTGGTT
CTTACTATCTCCAAGGAATCTTGGATGA

Domains

Predicted by InterproScan.

• Peptidase C39 family (Peptidase_C39) (7-142)

3D structure

• AlphaFold DB: Q9ETN5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	59.89	93.333	0.559
comA	Streptococcus mitis NCTC 12261	54.891	94.359	0.518
comA	Streptococcus mitis SK321	54.348	94.359	0.513
comA	Streptococcus pneumoniae TIGR4	53.804	94.359	0.508
comA	Streptococcus pneumoniae Rx1	53.804	94.359	0.508
comA	Streptococcus pneumoniae D39	53.804	94.359	0.508
comA	Streptococcus pneumoniae R6	53.804	94.359	0.508
comA	Streptococcus gordonii str. Challis substr. CH1	52.717	94.359	0.497