Detailed information NTG0715058

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: NQZ88_RS06145
• Genome accession: NZ_CP102152
• Coordinates: 1214241..1214912 (-)
• Length: 223 a.a.
• NCBI ID: WP_009909965.1
• Uniprot ID: A0A075SH40
• Organism: Streptococcus suis strain DNS11
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1209241..1219912

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
NQZ88_RS06125 (NQZ88_06125)	rpsT	1210055..1210303 (+)	249	WP_012027069.1	30S ribosomal protein S20	-
NQZ88_RS06130 (NQZ88_06130)	tnpA	1210477..1210950 (+)	474	WP_024378560.1	IS200/IS605 family transposase	-
NQZ88_RS06135 (NQZ88_06135)	-	1211316..1212545 (-)	1230	WP_023369936.1	transglutaminase domain-containing protein	-
NQZ88_RS06140 (NQZ88_06140)	ciaH	1212869..1214248 (-)	1380	WP_257116182.1	cell wall metabolism sensor histidine kinase WalK	Regulator
NQZ88_RS06145 (NQZ88_06145)	ciaR	1214241..1214912 (-)	672	WP_009909965.1	response regulator transcription factor	Regulator
NQZ88_RS06150 (NQZ88_06150)	-	1215106..1215486 (-)	381	WP_023369940.1	hypothetical protein	-
NQZ88_RS06155 (NQZ88_06155)	phoU	1215652..1216308 (-)	657	WP_002937611.1	phosphate signaling complex protein PhoU	-
NQZ88_RS06160 (NQZ88_06160)	pstB	1216337..1217095 (-)	759	WP_074389058.1	phosphate ABC transporter ATP-binding protein PstB	-
NQZ88_RS06165 (NQZ88_06165)	pstB	1217107..1217910 (-)	804	WP_002940866.1	phosphate ABC transporter ATP-binding protein PstB	-
NQZ88_RS06170 (NQZ88_06170)	pstA	1217935..1218822 (-)	888	WP_002937616.1	phosphate ABC transporter permease PstA	-
NQZ88_RS06175 (NQZ88_06175)	pstC	1218812..1219729 (-)	918	WP_002937619.1	phosphate ABC transporter permease subunit PstC	-

Sequence

Protein

• Length: 223 a.a.
• Molecular weight: 25290.00 Da
• Isoelectric Point: 4.2183

>NTDB_id=715058 NQZ88_RS06145 WP_009909965.1 1214241..1214912(-) (ciaR) [Streptococcus suis strain DNS11]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGEEGVYEAETGVYDLILLDLMLPEKDGFQVLKELREKGVTTPVLITTA
KESLEDKGHGFELGADDYLTKPFYLEELKMRIQALLKRAGKFNENTLTFGDVTVDLSTNMTMVNGEEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRIWGFDSDTTISVVEVYVSKIRKKLKGTTFGENLQTLRSVGYILKNA

Nucleotide

• Length: 672 bp

>NTDB_id=715058 NQZ88_RS06145 WP_009909965.1 1214241..1214912(-) (ciaR) [Streptococcus suis strain DNS11]
ATGATTAAAATATTGTTAGTGGAAGATGATTTAAGTCTATCAAATTCTGTTTTCGATTTCTTAGATGATTTTGCGGATGT
TATGCAGGTTTTTGATGGTGAAGAGGGCGTTTATGAGGCGGAAACAGGCGTTTATGATTTGATTCTTTTGGATTTGATGT
TGCCTGAAAAAGATGGCTTCCAAGTCTTGAAAGAGTTACGTGAAAAGGGGGTTACGACACCAGTTCTGATTACAACAGCC
AAGGAAAGTCTAGAGGATAAAGGCCATGGTTTTGAATTGGGGGCTGATGACTATTTGACAAAACCGTTTTATTTAGAAGA
ATTGAAGATGCGAATTCAAGCTCTATTAAAACGAGCGGGTAAGTTTAATGAAAACACACTAACCTTTGGAGATGTGACAG
TTGACCTATCTACAAATATGACGATGGTAAATGGCGAAGAAGTTGAACTGCTAGGAAAAGAATTTGATCTACTAGTTTAT
TTCTTGCAAAATCAAAATGTTATTTTGCCAAAAACACAAATTTTTGACCGTATTTGGGGCTTTGACAGTGATACTACAAT
TTCAGTAGTAGAAGTATATGTTTCTAAAATTAGGAAAAAGTTGAAAGGAACGACCTTCGGGGAAAATCTTCAAACCCTGC
GTAGTGTCGGGTACATTCTAAAAAATGCCTAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

3D structure

• AlphaFold DB: A0A075SH40

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus mutans UA159	90.135	100	0.901
ciaR	Streptococcus pneumoniae Rx1	88.341	100	0.883
ciaR	Streptococcus pneumoniae D39	88.341	100	0.883
ciaR	Streptococcus pneumoniae R6	88.341	100	0.883
ciaR	Streptococcus pneumoniae TIGR4	88.341	100	0.883
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.496	100	0.39
vicR	Streptococcus mutans UA159	35.47	100	0.372
covR	Streptococcus salivarius strain HSISS4	35.841	100	0.363