Detailed information NTG0714737

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: NQZ95_RS05910
• Genome accession: NZ_CP102138
• Coordinates: 1175252..1175923 (-)
• Length: 223 a.a.
• NCBI ID: WP_024385291.1
• Uniprot ID: A0A116K182
• Organism: Streptococcus suis strain M102942_S11
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1170252..1180923

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
NQZ95_RS05890 (NQZ95_05890)	coaA	1170836..1171756 (+)	921	WP_002935283.1	type I pantothenate kinase	-
NQZ95_RS05895 (NQZ95_05895)	rpsT	1171815..1172063 (+)	249	WP_012027069.1	30S ribosomal protein S20	-
NQZ95_RS05900 (NQZ95_05900)	-	1172327..1173556 (-)	1230	WP_248017884.1	transglutaminase domain-containing protein	-
NQZ95_RS05905 (NQZ95_05905)	ciaH	1173880..1175259 (-)	1380	WP_002935290.1	cell wall metabolism sensor histidine kinase WalK	Regulator
NQZ95_RS05910 (NQZ95_05910)	ciaR	1175252..1175923 (-)	672	WP_024385291.1	response regulator transcription factor	Regulator
NQZ95_RS10515	-	1176117..1176452 (-)	336	Protein_1133	hypothetical protein	-
NQZ95_RS05920 (NQZ95_05920)	phoU	1176618..1177274 (-)	657	WP_024394630.1	phosphate signaling complex protein PhoU	-
NQZ95_RS05925 (NQZ95_05925)	pstB	1177303..1178061 (-)	759	WP_002937614.1	phosphate ABC transporter ATP-binding protein PstB	-
NQZ95_RS05930 (NQZ95_05930)	pstB	1178073..1178876 (-)	804	WP_002937615.1	phosphate ABC transporter ATP-binding protein PstB	-
NQZ95_RS05935 (NQZ95_05935)	pstA	1178901..1179788 (-)	888	WP_002937616.1	phosphate ABC transporter permease PstA	-
NQZ95_RS05940 (NQZ95_05940)	pstC	1179778..1180695 (-)	918	WP_002937619.1	phosphate ABC transporter permease subunit PstC	-

Sequence

Protein

• Length: 223 a.a.
• Molecular weight: 25231.80 Da
• Isoelectric Point: 4.2183

>NTDB_id=714737 NQZ95_RS05910 WP_024385291.1 1175252..1175923(-) (ciaR) [Streptococcus suis strain M102942_S11]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGEEGVYEAETGVYDLILLDLMLPEKDGFQVLKELREKGVTTPVLITTA
KESLEDKGHGFELGADDYLTKPFYLEELKMRIQALLKRAGKFNENTLTYGDVTVDLSTNSTTVNGEEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRIWGFDSDTTISVVEVYVSKIRKKLKGTTFGENLQTLRSVGYILKNA

Nucleotide

• Length: 672 bp

>NTDB_id=714737 NQZ95_RS05910 WP_024385291.1 1175252..1175923(-) (ciaR) [Streptococcus suis strain M102942_S11]
ATGATTAAAATATTGTTAGTGGAAGATGATTTAAGTCTATCAAATTCTGTTTTCGATTTCTTAGATGATTTTGCGGATGT
TATGCAGGTTTTTGATGGTGAAGAGGGCGTTTATGAGGCGGAAACAGGCGTTTATGATTTGATTCTTTTGGATTTAATGT
TGCCTGAAAAAGATGGCTTCCAAGTTTTGAAAGAATTACGTGAAAAAGGTGTTACGACACCTGTTCTGATTACAACAGCC
AAGGAAAGTCTAGAGGATAAAGGCCATGGTTTTGAATTGGGGGCTGATGACTATTTGACGAAACCGTTTTATTTAGAAGA
ATTGAAGATGCGAATTCAAGCTCTATTAAAACGAGCGGGTAAGTTTAATGAAAACACACTAACTTATGGGGACGTGACCG
TTGACTTATCGACAAACTCTACAACTGTAAATGGCGAAGAAGTTGAACTGCTAGGAAAAGAATTTGATCTACTAGTTTAT
TTCTTGCAAAATCAAAATGTTATTTTGCCAAAAACACAAATTTTTGACCGTATTTGGGGCTTTGACAGTGATACTACAAT
TTCAGTAGTAGAAGTATATGTTTCTAAAATTAGGAAAAAGTTGAAAGGAACGACCTTTGGGGAAAATCTTCAAACCCTGC
GTAGTGTCGGATACATTCTAAAAAATGCCTAA

Domains

Predicted by InterproScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

• Response regulator receiver domain (Response_reg) (4-112)

3D structure

• AlphaFold DB: A0A116K182

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus mutans UA159	90.135	100	0.901
ciaR	Streptococcus pneumoniae Rx1	88.789	100	0.888
ciaR	Streptococcus pneumoniae D39	88.789	100	0.888
ciaR	Streptococcus pneumoniae R6	88.789	100	0.888
ciaR	Streptococcus pneumoniae TIGR4	88.789	100	0.888
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.053	100	0.386
vicR	Streptococcus mutans UA159	35.47	100	0.372
covR	Streptococcus salivarius strain HSISS4	36.283	100	0.368