Detailed information NTG0714638

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: NQZ97_RS05340
• Genome accession: NZ_CP102136
• Coordinates: 1083517..1084188 (+)
• Length: 223 a.a.
• NCBI ID: WP_014637852.1
• Uniprot ID: G7SGW2
• Organism: Streptococcus suis strain M105052_S26
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1078517..1089188

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
NQZ97_RS05310 (NQZ97_05310)	pstC	1078716..1079633 (+)	918	WP_125177039.1	phosphate ABC transporter permease subunit PstC	-
NQZ97_RS05315 (NQZ97_05315)	pstA	1079623..1080510 (+)	888	WP_014635996.1	phosphate ABC transporter permease PstA	-
NQZ97_RS05320 (NQZ97_05320)	pstB	1080535..1081338 (+)	804	WP_002940866.1	phosphate ABC transporter ATP-binding protein PstB	-
NQZ97_RS05325 (NQZ97_05325)	pstB	1081350..1082108 (+)	759	WP_257110696.1	phosphate ABC transporter ATP-binding protein PstB	-
NQZ97_RS05330 (NQZ97_05330)	phoU	1082137..1082793 (+)	657	WP_043033622.1	phosphate signaling complex protein PhoU	-
NQZ97_RS05335 (NQZ97_05335)	-	1082984..1083322 (+)	339	WP_238142829.1	hypothetical protein	-
NQZ97_RS05340 (NQZ97_05340)	ciaR	1083517..1084188 (+)	672	WP_014637852.1	response regulator transcription factor	Regulator
NQZ97_RS05345 (NQZ97_05345)	ciaH	1084181..1085560 (+)	1380	WP_257110697.1	cell wall metabolism sensor histidine kinase WalK	Regulator
NQZ97_RS05350 (NQZ97_05350)	-	1085661..1086890 (+)	1230	WP_105130789.1	transglutaminase domain-containing protein	-
NQZ97_RS05355 (NQZ97_05355)	rpsT	1087106..1087354 (-)	249	WP_012027069.1	30S ribosomal protein S20	-
NQZ97_RS05360 (NQZ97_05360)	coaA	1087413..1088333 (-)	921	WP_002940857.1	type I pantothenate kinase	-
NQZ97_RS05365 (NQZ97_05365)	-	1088442..1089032 (+)	591	WP_074411948.1	class I SAM-dependent methyltransferase	-

Sequence

Protein

• Length: 223 a.a.
• Molecular weight: 25245.83 Da
• Isoelectric Point: 4.2183

>NTDB_id=714638 NQZ97_RS05340 WP_014637852.1 1083517..1084188(+) (ciaR) [Streptococcus suis strain M105052_S26]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGEEGIYEAETGVYDLILLDLMLPEKDGFQVLKELREKGVTTPVLITTA
KESLEDKGHGFELGADDYLTKPFYLEELKMRIQALLKRAGKFNENTLTYGDVTVDLSTNSTTVNGEEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRIWGFDSDTTISVVEVYVSKIRKKLKGTTFGENLQTLRSVGYILKNA

Nucleotide

• Length: 672 bp

>NTDB_id=714638 NQZ97_RS05340 WP_014637852.1 1083517..1084188(+) (ciaR) [Streptococcus suis strain M105052_S26]
ATGATTAAGATTTTGTTAGTAGAAGACGATTTAAGCCTATCCAATTCAGTTTTTGACTTCCTAGATGATTTTGCAGATGT
CATGCAAGTTTTTGATGGTGAAGAAGGAATCTATGAAGCGGAAACTGGTGTGTACGACTTAATTTTATTAGATTTAATGT
TACCTGAAAAAGACGGCTTTCAAGTCTTGAAAGAGTTACGTGAAAAAGGTGTTACAACTCCTGTCTTGATTACAACAGCC
AAGGAAAGTCTAGAGGATAAAGGCCATGGTTTTGAATTGGGCGCTGATGACTACTTGACAAAACCGTTTTATTTAGAAGA
ATTGAAGATGCGAATTCAAGCTCTATTAAAACGAGCGGGTAAGTTTAATGAAAACACACTAACTTATGGGGATGTGACCG
TTGACTTATCGACAAACTCTACAACTGTAAATGGCGAAGAAGTTGAATTGCTAGGAAAAGAATTCGATCTACTGGTCTAC
TTCTTGCAAAATCAAAATGTTATCTTACCCAAAACTCAAATTTTTGATAGAATTTGGGGATTTGACAGTGACACTACTAT
TTCAGTAGTAGAAGTATATGTTTCTAAAATTAGGAAAAAGTTGAAAGGAACGACCTTCGGGGAAAATCTTCAAACCCTGC
GTAGTGTCGGGTATATTCTAAAAAATGCCTAA

Domains

Predicted by InterproScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

• Response regulator receiver domain (Response_reg) (4-112)

3D structure

• AlphaFold DB: G7SGW2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus mutans UA159	90.135	100	0.901
ciaR	Streptococcus pneumoniae Rx1	88.789	100	0.888
ciaR	Streptococcus pneumoniae D39	88.789	100	0.888
ciaR	Streptococcus pneumoniae R6	88.789	100	0.888
ciaR	Streptococcus pneumoniae TIGR4	88.789	100	0.888
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.053	100	0.386
vicR	Streptococcus mutans UA159	35.47	100	0.372
covR	Streptococcus salivarius strain HSISS4	36.283	100	0.368