Detailed information NTG0714582

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: NQZ98_RS05875
• Genome accession: NZ_CP102135
• Coordinates: 1162351..1163022 (-)
• Length: 223 a.a.
• NCBI ID: WP_024403127.1
• Uniprot ID: A0A0Z8J668
• Organism: Streptococcus suis strain M106471_S40
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1157351..1168022

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
NQZ98_RS05855 (NQZ98_05855)	coaA	1157937..1158857 (+)	921	WP_024400690.1	type I pantothenate kinase	-
NQZ98_RS05860 (NQZ98_05860)	rpsT	1158916..1159164 (+)	249	WP_012027069.1	30S ribosomal protein S20	-
NQZ98_RS05865 (NQZ98_05865)	-	1159546..1160655 (-)	1110	WP_228381088.1	transglutaminase domain-containing protein	-
NQZ98_RS05870 (NQZ98_05870)	ciaH	1160979..1162358 (-)	1380	WP_024412151.1	cell wall metabolism sensor histidine kinase WalK	Regulator
NQZ98_RS05875 (NQZ98_05875)	ciaR	1162351..1163022 (-)	672	WP_024403127.1	response regulator transcription factor	Regulator
NQZ98_RS05880 (NQZ98_05880)	-	1163216..1163596 (-)	381	WP_024403128.1	hypothetical protein	-
NQZ98_RS05885 (NQZ98_05885)	phoU	1163762..1164418 (-)	657	WP_002937611.1	phosphate signaling complex protein PhoU	-
NQZ98_RS05890 (NQZ98_05890)	pstB	1164447..1165205 (-)	759	WP_002937614.1	phosphate ABC transporter ATP-binding protein PstB	-
NQZ98_RS05895 (NQZ98_05895)	pstB	1165217..1166020 (-)	804	WP_002940866.1	phosphate ABC transporter ATP-binding protein PstB	-
NQZ98_RS05900 (NQZ98_05900)	pstA	1166045..1166932 (-)	888	WP_105106214.1	phosphate ABC transporter permease PstA	-
NQZ98_RS05905 (NQZ98_05905)	pstC	1166922..1167839 (-)	918	WP_002937619.1	phosphate ABC transporter permease subunit PstC	-

Sequence

Protein

• Length: 223 a.a.
• Molecular weight: 25304.03 Da
• Isoelectric Point: 4.2183

>NTDB_id=714582 NQZ98_RS05875 WP_024403127.1 1162351..1163022(-) (ciaR) [Streptococcus suis strain M106471_S40]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGEEGIYEAETGVYDLILLDLMLPEKDGFQVLKELREKGVTTPVLITTA
KESLEDKGHGFELGADDYLTKPFYLEELKMRIQALLKRAGKFNENTLTFGDVTVDLSTNMTMVNGEEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRIWGFDSDTTISVVEVYVSKIRKKLKGTTFGENLQTLRSVGYILKNA

Nucleotide

• Length: 672 bp

>NTDB_id=714582 NQZ98_RS05875 WP_024403127.1 1162351..1163022(-) (ciaR) [Streptococcus suis strain M106471_S40]
ATGATTAAAATATTGTTAGTGGAAGATGATTTAAGTCTATCAAATTCTGTTTTCGATTTCTTAGATGATTTTGCGGATGT
TATGCAGGTTTTTGATGGTGAAGAGGGTATTTATGAGGCGGAAACAGGCGTTTATGATTTGATTCTTTTGGATTTGATGT
TGCCTGAAAAAGATGGCTTCCAAGTTTTGAAAGAGTTACGTGAAAAAGGTGTTACGACACCAGTTCTGATTACAACAGCC
AAGGAAAGTCTAGAGGATAAAGGCCATGGTTTTGAATTGGGAGCTGATGACTACTTGACAAAACCGTTTTATTTAGAAGA
ATTGAAGATGCGAATTCAAGCTCTATTAAAACGAGCGGGTAAGTTTAATGAAAACACACTAACCTTTGGAGATGTGACAG
TTGACCTATCTACAAATATGACGATGGTAAATGGCGAAGAAGTTGAACTGCTAGGAAAAGAATTTGACCTACTAGTTTAT
TTCTTGCAAAATCAAAATGTTATTTTGCCAAAAACACAAATTTTTGACCGTATTTGGGGCTTTGACAGTGATACTACAAT
TTCAGTAGTAGAAGTATATGTTTCTAAAATTAGGAAAAAGTTGAAAGGAACGACTTTTGGGGAAAATCTTCAAACCCTGC
GTAGTGTCGGATACATTCTAAAAAATGCCTAA

Domains

Predicted by InterproScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

• Response regulator receiver domain (Response_reg) (4-112)

3D structure

• AlphaFold DB: A0A0Z8J668

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus mutans UA159	90.135	100	0.901
ciaR	Streptococcus pneumoniae Rx1	88.341	100	0.883
ciaR	Streptococcus pneumoniae D39	88.341	100	0.883
ciaR	Streptococcus pneumoniae R6	88.341	100	0.883
ciaR	Streptococcus pneumoniae TIGR4	88.341	100	0.883
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.496	100	0.39
vicR	Streptococcus mutans UA159	35.47	100	0.372
covR	Streptococcus salivarius strain HSISS4	35.841	100	0.363