Detailed information NTG0705213

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: NLY76_RS04050
• Genome accession: NZ_CP100430
• Coordinates: 831887..832558 (+)
• Length: 223 a.a.
• NCBI ID: WP_014637852.1
• Uniprot ID: G7SGW2
• Organism: Streptococcus suis strain LSS42
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 826887..837558

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
NLY76_RS04020 (NLY76_04020)	pstC	827070..827987 (+)	918	WP_002937619.1	phosphate ABC transporter permease subunit PstC	-
NLY76_RS04025 (NLY76_04025)	pstA	827977..828864 (+)	888	WP_044757644.1	phosphate ABC transporter permease PstA	-
NLY76_RS04030 (NLY76_04030)	pstB	828889..829692 (+)	804	WP_002937615.1	phosphate ABC transporter ATP-binding protein PstB	-
NLY76_RS04035 (NLY76_04035)	pstB	829704..830462 (+)	759	WP_002937614.1	phosphate ABC transporter ATP-binding protein PstB	-
NLY76_RS04040 (NLY76_04040)	phoU	830491..831147 (+)	657	WP_044769841.1	phosphate signaling complex protein PhoU	-
NLY76_RS04045 (NLY76_04045)	-	831313..831693 (+)	381	WP_044666718.1	hypothetical protein	-
NLY76_RS04050 (NLY76_04050)	ciaR	831887..832558 (+)	672	WP_014637852.1	response regulator transcription factor	Regulator
NLY76_RS04055 (NLY76_04055)	ciaH	832551..833930 (+)	1380	WP_014635993.1	cell wall metabolism sensor histidine kinase WalK	Regulator
NLY76_RS04060 (NLY76_04060)	-	834030..835259 (+)	1230	WP_044769839.1	transglutaminase domain-containing protein	-
NLY76_RS04065 (NLY76_04065)	rpsT	835524..835772 (-)	249	WP_012027069.1	30S ribosomal protein S20	-
NLY76_RS04070 (NLY76_04070)	coaA	835831..836751 (-)	921	WP_044684617.1	type I pantothenate kinase	-
NLY76_RS04075 (NLY76_04075)	-	836860..837450 (+)	591	WP_014637855.1	class I SAM-dependent methyltransferase	-

Sequence

Protein

• Length: 223 a.a.
• Molecular weight: 25245.83 Da
• Isoelectric Point: 4.2183

>NTDB_id=705213 NLY76_RS04050 WP_014637852.1 831887..832558(+) (ciaR) [Streptococcus suis strain LSS42]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGEEGIYEAETGVYDLILLDLMLPEKDGFQVLKELREKGVTTPVLITTA
KESLEDKGHGFELGADDYLTKPFYLEELKMRIQALLKRAGKFNENTLTYGDVTVDLSTNSTTVNGEEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRIWGFDSDTTISVVEVYVSKIRKKLKGTTFGENLQTLRSVGYILKNA

Nucleotide

• Length: 672 bp

>NTDB_id=705213 NLY76_RS04050 WP_014637852.1 831887..832558(+) (ciaR) [Streptococcus suis strain LSS42]
ATGATTAAAATATTGTTAGTGGAAGATGATTTAAGTCTATCAAATTCTGTTTTCGATTTCTTGGATGATTTTGCGGATGT
TATGCAGGTTTTTGATGGTGAAGAGGGTATTTATGAGGCGGAAACAGGCGTTTATGATTTGATTCTTTTGGATTTGATGT
TGCCTGAAAAAGATGGCTTCCAAGTTTTGAAAGAGTTACGTGAAAAAGGTGTTACGACACCAGTTCTGATTACAACAGCC
AAGGAAAGTCTAGAGGATAAAGGCCATGGTTTTGAATTGGGAGCTGATGACTACTTGACAAAACCGTTTTATTTAGAAGA
ATTGAAGATGCGAATTCAAGCTCTATTAAAACGAGCGGGTAAGTTTAATGAAAACACACTAACTTATGGGGATGTGACCG
TTGACTTATCGACAAACTCTACAACTGTAAATGGCGAAGAAGTTGAATTGCTAGGAAAAGAATTCGATCTACTAGTCTAC
TTTTTGCAAAATCAAAATGTTATCTTGCCAAAAACTCAAATTTTTGACCGTATTTGGGGATTTGACAGTGACACTACTAT
TTCAGTAGTAGAAGTATATGTTTCTAAAATTAGGAAAAAGTTGAAAGGAACGACTTTCGGGGAAAATCTTCAAACCCTGC
GTAGTGTCGGGTACATTCTAAAAAATGCCTAA

Domains

Predicted by InterproScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

• Response regulator receiver domain (Response_reg) (4-112)

3D structure

• AlphaFold DB: G7SGW2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus mutans UA159	90.135	100	0.901
ciaR	Streptococcus pneumoniae Rx1	88.789	100	0.888
ciaR	Streptococcus pneumoniae D39	88.789	100	0.888
ciaR	Streptococcus pneumoniae R6	88.789	100	0.888
ciaR	Streptococcus pneumoniae TIGR4	88.789	100	0.888
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.053	100	0.386
vicR	Streptococcus mutans UA159	35.47	100	0.372
covR	Streptococcus salivarius strain HSISS4	36.283	100	0.368