Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpP   Type   Regulator
Locus tag   NKZ80_RS08005 Genome accession   NZ_CP100330
Coordinates   1605000..1605611 (-) Length   203 a.a.
NCBI ID   WP_223375679.1    Uniprot ID   -
Organism   Streptococcus suis strain STC85     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 1558165..1605590 1605000..1605611 flank -590


Gene organization within MGE regions


Location: 1558165..1605611
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  NKZ80_RS07655 (NKZ80_07655) - 1558165..1558542 (-) 378 WP_024394270.1 PBECR2 nuclease fold domain-containing protein -
  NKZ80_RS07660 (NKZ80_07660) - 1558607..1559344 (-) 738 WP_014636660.1 PlySs2 family phage lysin -
  NKZ80_RS07665 (NKZ80_07665) - 1559328..1559678 (-) 351 WP_002937841.1 phage holin -
  NKZ80_RS07670 (NKZ80_07670) - 1559681..1559980 (-) 300 WP_014636661.1 hypothetical protein -
  NKZ80_RS07675 (NKZ80_07675) - 1559984..1560328 (-) 345 WP_002937844.1 hypothetical protein -
  NKZ80_RS07680 (NKZ80_07680) - 1560331..1560549 (-) 219 WP_002937846.1 hypothetical protein -
  NKZ80_RS07685 (NKZ80_07685) - 1560558..1565900 (-) 5343 WP_204101658.1 phage tail spike protein -
  NKZ80_RS07690 (NKZ80_07690) - 1565897..1566592 (-) 696 WP_002937853.1 adenylosuccinate synthetase -
  NKZ80_RS07695 (NKZ80_07695) - 1566592..1569174 (-) 2583 WP_044768633.1 phage tail protein -
  NKZ80_RS07700 (NKZ80_07700) - 1569164..1569547 (-) 384 WP_002937861.1 DUF5361 domain-containing protein -
  NKZ80_RS07705 (NKZ80_07705) - 1569544..1569822 (-) 279 WP_024379224.1 hypothetical protein -
  NKZ80_RS07710 (NKZ80_07710) - 1569833..1570420 (-) 588 WP_204101659.1 phage tail protein -
  NKZ80_RS07715 (NKZ80_07715) - 1570436..1570771 (-) 336 WP_002937874.1 hypothetical protein -
  NKZ80_RS07720 (NKZ80_07720) - 1570768..1571007 (-) 240 WP_002937877.1 hypothetical protein -
  NKZ80_RS07725 (NKZ80_07725) - 1571000..1571338 (-) 339 WP_002937879.1 hypothetical protein -
  NKZ80_RS07730 (NKZ80_07730) - 1571325..1571720 (-) 396 WP_002937880.1 phage Gp19/Gp15/Gp42 family protein -
  NKZ80_RS07735 (NKZ80_07735) - 1571724..1571948 (-) 225 WP_002937881.1 HeH/LEM domain-containing protein -
  NKZ80_RS07740 (NKZ80_07740) - 1571950..1572852 (-) 903 WP_002937882.1 phage major capsid protein -
  NKZ80_RS07745 (NKZ80_07745) - 1572867..1573337 (-) 471 WP_002937883.1 DUF4355 domain-containing protein -
  NKZ80_RS07750 (NKZ80_07750) - 1573420..1574835 (-) 1416 WP_002937884.1 terminase -
  NKZ80_RS11290 - 1574980..1575111 (-) 132 WP_002937886.1 hypothetical protein -
  NKZ80_RS07755 (NKZ80_07755) - 1575180..1575392 (-) 213 WP_002937901.1 hypothetical protein -
  NKZ80_RS07760 (NKZ80_07760) - 1575389..1576468 (-) 1080 WP_002937903.1 hypothetical protein -
  NKZ80_RS07765 (NKZ80_07765) - 1576461..1577726 (-) 1266 WP_002937907.1 phage portal protein -
  NKZ80_RS07770 (NKZ80_07770) - 1577723..1578085 (-) 363 WP_002937910.1 hypothetical protein -
  NKZ80_RS07775 (NKZ80_07775) - 1578164..1578511 (-) 348 WP_002937914.1 HNH endonuclease -
  NKZ80_RS07780 (NKZ80_07780) - 1578608..1579042 (-) 435 WP_002937915.1 DUF1492 domain-containing protein -
  NKZ80_RS07785 (NKZ80_07785) - 1579119..1579385 (-) 267 WP_226314725.1 hypothetical protein -
  NKZ80_RS07790 (NKZ80_07790) - 1579382..1579651 (-) 270 WP_002937922.1 hypothetical protein -
  NKZ80_RS07795 (NKZ80_07795) - 1579651..1579827 (-) 177 WP_002937925.1 hypothetical protein -
  NKZ80_RS07800 (NKZ80_07800) - 1579827..1580060 (-) 234 WP_002937935.1 hypothetical protein -
  NKZ80_RS07805 (NKZ80_07805) - 1580076..1580378 (-) 303 WP_002937939.1 DUF1372 family protein -
  NKZ80_RS07810 (NKZ80_07810) - 1580388..1580906 (-) 519 WP_002937943.1 hypothetical protein -
  NKZ80_RS07815 (NKZ80_07815) - 1580903..1581235 (-) 333 WP_002937944.1 hypothetical protein -
  NKZ80_RS07820 (NKZ80_07820) - 1581325..1581513 (-) 189 WP_254377503.1 hypothetical protein -
  NKZ80_RS07825 (NKZ80_07825) - 1581548..1581922 (-) 375 WP_002937949.1 hypothetical protein -
  NKZ80_RS07830 (NKZ80_07830) ssb 1581950..1582411 (-) 462 WP_002937951.1 single-stranded DNA-binding protein Machinery gene
  NKZ80_RS07835 (NKZ80_07835) - 1582514..1582693 (-) 180 WP_002937955.1 hypothetical protein -
  NKZ80_RS07840 (NKZ80_07840) - 1582683..1583009 (-) 327 WP_002937956.1 hypothetical protein -
  NKZ80_RS07845 (NKZ80_07845) - 1583019..1583288 (-) 270 WP_002937957.1 hypothetical protein -
  NKZ80_RS07850 (NKZ80_07850) - 1583291..1584319 (-) 1029 WP_172055947.1 DUF1351 domain-containing protein -
  NKZ80_RS07855 (NKZ80_07855) bet 1584329..1585099 (-) 771 WP_014636675.1 phage recombination protein Bet -
  NKZ80_RS07860 (NKZ80_07860) - 1585096..1585275 (-) 180 WP_004195116.1 hypothetical protein -
  NKZ80_RS11295 - 1585275..1585403 (-) 129 WP_014636676.1 hypothetical protein -
  NKZ80_RS07865 (NKZ80_07865) - 1585414..1585557 (-) 144 WP_014636677.1 hypothetical protein -
  NKZ80_RS07870 (NKZ80_07870) - 1585816..1586181 (-) 366 WP_004194647.1 hypothetical protein -
  NKZ80_RS07875 (NKZ80_07875) - 1586234..1586458 (-) 225 WP_004194648.1 hypothetical protein -
  NKZ80_RS07880 (NKZ80_07880) - 1586439..1586696 (-) 258 WP_014636678.1 hypothetical protein -
  NKZ80_RS07885 (NKZ80_07885) - 1586693..1586968 (-) 276 WP_014636679.1 hypothetical protein -
  NKZ80_RS07890 (NKZ80_07890) - 1587051..1587761 (-) 711 WP_014636680.1 phage antirepressor KilAC domain-containing protein -
  NKZ80_RS07895 (NKZ80_07895) - 1587815..1588504 (+) 690 WP_014636681.1 DUF4145 domain-containing protein -
  NKZ80_RS07900 (NKZ80_07900) - 1588600..1588821 (-) 222 WP_004195135.1 hypothetical protein -
  NKZ80_RS07905 (NKZ80_07905) - 1588874..1589101 (-) 228 WP_024414969.1 hypothetical protein -
  NKZ80_RS07910 (NKZ80_07910) - 1589108..1589299 (-) 192 WP_172051330.1 helix-turn-helix transcriptional regulator -
  NKZ80_RS11300 - 1589442..1589570 (+) 129 WP_255199034.1 hypothetical protein -
  NKZ80_RS07915 (NKZ80_07915) - 1589560..1589943 (-) 384 WP_226314723.1 ImmA/IrrE family metallo-endopeptidase -
  NKZ80_RS07920 (NKZ80_07920) - 1590014..1590208 (-) 195 WP_204108029.1 hypothetical protein -
  NKZ80_RS07925 (NKZ80_07925) - 1590307..1591071 (+) 765 WP_172051331.1 XRE family transcriptional regulator -
  NKZ80_RS07930 (NKZ80_07930) - 1591247..1591681 (+) 435 WP_004194675.1 type II toxin-antitoxin system PemK/MazF family toxin -
  NKZ80_RS07935 (NKZ80_07935) - 1591807..1592901 (+) 1095 WP_201326760.1 tyrosine-type recombinase/integrase -
  NKZ80_RS07945 (NKZ80_07945) - 1593208..1595232 (-) 2025 WP_029743814.1 bifunctional UDP-sugar hydrolase/5'-nucleotidase -
  NKZ80_RS07950 (NKZ80_07950) - 1595372..1596325 (-) 954 WP_024376800.1 IS30 family transposase -
  NKZ80_RS07955 (NKZ80_07955) sodA 1596739..1597344 (-) 606 WP_013730459.1 superoxide dismutase SodA -
  NKZ80_RS07960 (NKZ80_07960) holA 1597457..1598488 (-) 1032 WP_024417674.1 DNA polymerase III subunit delta -
  NKZ80_RS07965 (NKZ80_07965) - 1598638..1599228 (-) 591 WP_024402863.1 hypothetical protein -
  NKZ80_RS07970 (NKZ80_07970) - 1599341..1599703 (-) 363 Protein_1530 epoxyqueuosine reductase QueH -
  NKZ80_RS07975 (NKZ80_07975) - 1599793..1600503 (-) 711 WP_002937288.1 ABC transporter ATP-binding protein -
  NKZ80_RS07980 (NKZ80_07980) - 1600503..1601267 (-) 765 WP_029176900.1 ABC transporter ATP-binding protein -
  NKZ80_RS07985 (NKZ80_07985) - 1601267..1602214 (-) 948 WP_024378398.1 branched-chain amino acid ABC transporter permease -
  NKZ80_RS07990 (NKZ80_07990) - 1602217..1603104 (-) 888 WP_204101587.1 branched-chain amino acid ABC transporter permease -
  NKZ80_RS07995 (NKZ80_07995) - 1603300..1604469 (-) 1170 WP_044760026.1 ABC transporter substrate-binding protein -
  NKZ80_RS08000 (NKZ80_08000) - 1604601..1604873 (-) 273 WP_002937299.1 YlbG family protein -
  NKZ80_RS08005 (NKZ80_08005) clpP 1605000..1605611 (-) 612 WP_223375679.1 ATP-dependent Clp protease proteolytic subunit Regulator

Sequence

Protein


Download         Length: 203 a.a.        Molecular weight: 22345.73 Da        Isoelectric Point: 6.7324

>NTDB_id=704398 NKZ80_RS08005 WP_223375679.1 1605000..1605611(-) (clpP) [Streptococcus suis strain STC85]
MSKRSNFMIPVVIEQTSRGERSYDIYSRLLKDRIIMLTGPVEDNMANSIIAQLLFLDAQDPTKDIYLYVNTPGGSVSAGL
AIVDTMNFIKADVQTIVMGTAASMGTIIASSGAKGKRFMLPNAEYMIHQPMGGTGGGTQQTDMAIAAEHLLKTRNKLEKI
LADNSGKTVKQIHKDAERDYWMSAEETLAYGFIDQIMDNTKVK

Nucleotide


Download         Length: 612 bp        

>NTDB_id=704398 NKZ80_RS08005 WP_223375679.1 1605000..1605611(-) (clpP) [Streptococcus suis strain STC85]
ATCTCGAAAAGGAGTAATTTTATGATTCCAGTAGTTATTGAACAAACTAGCCGTGGTGAACGTTCTTATGATATTTATTC
ACGCCTATTGAAAGATCGTATTATCATGCTGACAGGACCAGTTGAGGATAATATGGCAAACTCTATCATTGCACAATTGC
TTTTCCTTGATGCCCAAGACCCTACAAAGGATATTTACCTCTATGTTAACACGCCAGGAGGATCGGTGTCAGCAGGTCTT
GCCATTGTAGACACGATGAATTTCATTAAAGCTGATGTGCAAACCATCGTCATGGGGACAGCTGCTAGCATGGGTACAAT
TATCGCTTCAAGTGGTGCCAAAGGCAAACGTTTCATGTTGCCAAATGCGGAATACATGATTCACCAACCAATGGGTGGAA
CTGGTGGCGGTACTCAGCAAACGGATATGGCCATTGCTGCAGAACACCTATTAAAAACACGTAATAAGCTAGAAAAAATC
TTGGCAGACAACTCAGGTAAGACAGTCAAGCAAATCCACAAGGATGCGGAACGTGATTACTGGATGTCAGCTGAAGAAAC
CTTGGCTTACGGATTTATTGACCAGATTATGGACAATACAAAAGTCAAATAA

Domains

Predicted by InterproScan.

Clp protease (CLP_protease)

(18-199)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpP Streptococcus pyogenes JRS4

92.347

96.552

0.892
  clpP Streptococcus pyogenes MGAS315

92.347

96.552

0.892
  clpP Streptococcus mutans UA159

90.306

96.552

0.872
  clpP Streptococcus thermophilus LMD-9

88.776

96.552

0.857
  clpP Streptococcus thermophilus LMG 18311

88.776

96.552

0.857
  clpP Streptococcus pneumoniae R6

89.231

96.059

0.857
  clpP Streptococcus pneumoniae Rx1

89.231

96.059

0.857
  clpP Streptococcus pneumoniae D39

89.231

96.059

0.857
  clpP Streptococcus pneumoniae TIGR4

89.231

96.059

0.857
  clpP Lactococcus lactis subsp. lactis strain DGCC12653

83.756

97.044

0.813
  clpP Lactococcus lactis subsp. cremoris KW2

83.249

97.044

0.808
  clpP Bacillus subtilis subsp. subtilis str. 168

58.163

96.552

0.562
  clpP Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819

58.549

95.074

0.557