Detailed information NTG0701220

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: NEE09_RS08560
• Genome accession: NZ_CP099641
• Coordinates: 1643919..1644506 (+)
• Length: 195 a.a.
• NCBI ID: WP_001810228.1
• Uniprot ID: A0A380LSF4
• Organism: Streptococcus pneumoniae strain ATCC 700671
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 1638919..1649506

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
NEE09_RS08505	-	1639180..1639299 (-)	120	WP_000346296.1	PncF family bacteriocin immunity protein	-
NEE09_RS08510	cipB	1639403..1639552 (-)	150	WP_001809846.1	bacteriocin-like peptide BlpO	Regulator
NEE09_RS08515	blpN	1639796..1639999 (-)	204	WP_001099492.1	two-peptide bacteriocin subunit BlpN	-
NEE09_RS08520	blpM	1640015..1640269 (-)	255	WP_000379879.1	two-peptide bacteriocin subunit BlpM	-
NEE09_RS08525	-	1640419..1641223 (-)	805	Protein_1634	IS5 family transposase	-
NEE09_RS08530	-	1641421..1641825 (-)	405	WP_000846944.1	hypothetical protein	-
NEE09_RS08535	-	1641822..1641986 (-)	165	WP_000727118.1	hypothetical protein	-
NEE09_RS08540	-	1642283..1642402 (-)	120	WP_000346298.1	PncF family bacteriocin immunity protein	-
NEE09_RS08545	blpU	1642405..1642635 (-)	231	WP_000379964.1	bacteriocin-like peptide BlpU	-
NEE09_RS08550	blpJ	1642704..1642973 (-)	270	WP_001093248.1	bacteriocin-like peptide BlpJ	-
NEE09_RS08555	blpI	1643440..1643637 (-)	198	WP_001093259.1	bacteriocin-like peptide BlpI	-
NEE09_RS08560	comA/nlmT	1643919..1644506 (+)	588	WP_001810228.1	cysteine peptidase family C39 domain-containing protein	Regulator
NEE09_RS08565	comA/nlmT	1644433..1646076 (+)	1644	WP_078133841.1	peptide cleavage/export ABC transporter	Regulator
NEE09_RS08570	-	1646087..1647448 (+)	1362	WP_001069091.1	bacteriocin secretion accessory protein	-
NEE09_RS08575	blpC	1647505..1647660 (+)	156	WP_000358817.1	quorum-sensing system pheromone BlpC	-
NEE09_RS08580	-	1647702..1649042 (-)	1341	WP_001017638.1	sensor histidine kinase	-

Sequence

Protein

• Length: 195 a.a.
• Molecular weight: 22369.84 Da
• Isoelectric Point: 9.7306

>NTDB_id=701220 NEE09_RS08560 WP_001810228.1 1643919..1644506(+) (comA/nlmT) [Streptococcus pneumoniae strain ATCC 700671]
MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKTNKEGTTALGIVKAADEMGFETRPVQADKTLFDMSDV
PYPFIVHVNKEGKLQHYYVVYQTKKDYLIIGDPDPSVKITKMSKERFFYEWTGVAIFLATKPSYQPHKDKKNGLLSKLPS
SDFQTKISHCLHCSLKLIGHYYQYRWFLLSPRNLR

Nucleotide

• Length: 588 bp

>NTDB_id=701220 NEE09_RS08560 WP_001810228.1 1643919..1644506(+) (comA/nlmT) [Streptococcus pneumoniae strain ATCC 700671]
ATGACTTCTTATAAACGTACATTTGTTCCTCAAATAGATGCGAGAGACTGTGGTGTCGCTGCCTTAGCCTCGATTGCTAA
ATTCTATGGTTCAGATTTTTCTCTAGCTCACTTGAGAGAACTTGCAAAGACCAATAAAGAAGGGACGACTGCTCTTGGCA
TTGTAAAAGCCGCTGATGAAATGGGCTTTGAAACAAGACCTGTTCAAGCAGATAAAACGCTCTTTGACATGAGTGATGTC
CCCTATCCATTTATCGTTCACGTTAACAAAGAAGGAAAACTCCAACATTACTATGTTGTCTATCAAACAAAGAAAGACTA
TCTGATTATTGGTGATCCTGACCCTTCTGTAAAAATCACTAAAATGTCAAAAGAACGCTTTTTCTATGAATGGACTGGAG
TAGCTATTTTTCTAGCTACCAAACCCAGCTATCAACCCCATAAAGATAAAAAGAATGGTCTACTAAGCAAGCTTCCTTCC
TCTGATTTTCAAACAAAAATCTCTCATTGCTTACATTGTTCTCTCAAGCTTATTGGTCACTATTATCAATATAGGTGGTT
CTTACTATCTCCAAGGAATCTTAGATGA

Domains

Predicted by InterproScan.

• Peptidase C39 family (Peptidase_C39) (7-142)

3D structure

• AlphaFold DB: A0A380LSF4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	59.89	93.333	0.559
comA	Streptococcus mitis NCTC 12261	54.891	94.359	0.518
comA	Streptococcus mitis SK321	54.348	94.359	0.513
comA	Streptococcus pneumoniae TIGR4	53.804	94.359	0.508
comA	Streptococcus pneumoniae Rx1	53.804	94.359	0.508
comA	Streptococcus pneumoniae D39	53.804	94.359	0.508
comA	Streptococcus pneumoniae R6	53.804	94.359	0.508
comA	Streptococcus gordonii str. Challis substr. CH1	52.717	94.359	0.497