Detailed information NTG0069805

Bioinformatically predicted

Overview

• Name: covR
• Type: Regulator
• Locus tag: LLCC_RS07055
• Genome accession: NZ_AP018499
• Coordinates: 1346116..1346808 (+)
• Length: 230 a.a.
• NCBI ID: WP_011676631.1
• Uniprot ID: A0A0M2ZTN8
• Organism: Lactococcus cremoris strain C4
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1341116..1351808

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LLCC_RS07025 (LLCC_1495)	-	1341240..1342415 (+)	1176	WP_003138385.1	IS256-like element IS905 family transposase	-
LLCC_RS14150 (LLCC_1496)	-	1342453..1342893 (+)	441	WP_232034967.1	metallophosphoesterase	-
LLCC_RS14155 (LLCC_1497)	-	1342985..1343125 (+)	141	WP_232034968.1	hypothetical protein	-
LLCC_RS07035 (LLCC_1498)	-	1343218..1344129 (+)	912	WP_021212488.1	CHAP domain-containing protein	-
LLCC_RS07040	-	1344366..1344728 (+)	363	Protein_1351	TIGR02328 family protein	-
LLCC_RS07045 (LLCC_1500)	-	1345052..1345297 (+)	246	WP_011676633.1	type B 50S ribosomal protein L31	-
LLCC_RS07050 (LLCC_1501)	-	1345430..1345960 (+)	531	WP_011834860.1	YceD family protein	-
LLCC_RS07055 (LLCC_1502)	covR	1346116..1346808 (+)	693	WP_011676631.1	response regulator transcription factor	Regulator
LLCC_RS07060 (LLCC_1503)	covS	1346821..1348293 (+)	1473	WP_021211938.1	HAMP domain-containing histidine kinase	Regulator
LLCC_RS07065 (LLCC_1504)	-	1348479..1349720 (+)	1242	WP_015082643.1	ammonium transporter	-
LLCC_RS07070 (LLCC_1505)	-	1349805..1350146 (+)	342	WP_011676628.1	P-II family nitrogen regulator	-
LLCC_RS07075 (LLCC_1506)	murD	1350315..1351664 (+)	1350	WP_021211936.1	UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase	-

Sequence

Protein

• Length: 230 a.a.
• Molecular weight: 26654.33 Da
• Isoelectric Point: 5.1273

>NTDB_id=69805 LLCC_RS07055 WP_011676631.1 1346116..1346808(+) (covR) [Lactococcus cremoris strain C4]
MASKKILIIEDEKNLARFVSLELEHEGYATEIKDNGRSGLEEATSKDYDLILLDLMLPELDGFEVARRLRKEKDTPIIMM
TARDSTMDRVAGLDIGADDYITKPFAIEELLARVRAFFRREEHGHAVERAENTSFRDLVIDKTNRTVHRGKKVIDLTRRE
YDLLLTLMQNVGDVVTREHLVSQVWGYEEGTETNVVDVYIRYLRNKIDVEGQDSYIQTVRGLGYVMRERK

Nucleotide

• Length: 693 bp

>NTDB_id=69805 LLCC_RS07055 WP_011676631.1 1346116..1346808(+) (covR) [Lactococcus cremoris strain C4]
ATGGCATCAAAGAAAATTTTGATTATTGAGGATGAAAAGAATTTAGCTCGTTTCGTCTCATTAGAATTAGAGCATGAAGG
CTATGCCACTGAGATTAAAGATAACGGACGTTCTGGGCTTGAAGAAGCAACTTCAAAAGATTATGATTTAATCTTGCTTG
ATTTGATGCTTCCTGAACTTGATGGTTTTGAAGTTGCCCGCCGTTTGCGCAAAGAAAAAGATACTCCAATTATTATGATG
ACCGCGCGTGATTCAACAATGGACCGTGTTGCCGGTCTTGATATTGGAGCAGATGATTATATTACTAAGCCTTTTGCGAT
TGAAGAACTTTTGGCTCGTGTTCGTGCATTCTTCCGTCGTGAAGAACATGGTCATGCTGTAGAACGTGCTGAAAACACTT
CTTTTCGTGATCTTGTAATTGACAAAACAAATCGTACCGTTCACCGCGGTAAAAAAGTAATTGATTTGACGCGTCGTGAA
TACGATCTTCTTTTGACGTTGATGCAAAATGTTGGGGATGTTGTCACTCGCGAACATTTAGTTTCACAAGTTTGGGGATA
TGAAGAAGGAACGGAAACAAATGTTGTTGATGTATATATCCGCTATCTTAGAAATAAAATTGATGTTGAAGGACAAGACA
GCTATATTCAAACCGTTCGTGGTTTGGGTTATGTGATGCGTGAACGCAAATAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (6-115)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (153-226)

3D structure

• AlphaFold DB: A0A0M2ZTN8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
covR	Lactococcus lactis subsp. lactis strain DGCC12653	99.565	100	0.996
covR	Streptococcus salivarius strain HSISS4	68.421	99.13	0.678
vicR	Streptococcus mutans UA159	45.887	100	0.461
micA	Streptococcus pneumoniae Cp1015	43.478	100	0.435
ciaR	Streptococcus mutans UA159	37.611	98.261	0.37
ciaR	Streptococcus pneumoniae Rx1	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae D39	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae R6	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae TIGR4	36.726	98.261	0.361