Detailed information    

insolico Bioinformatically predicted

Overview

Name   micA   Type   Regulator
Locus tag   SR187_RS02930 Genome accession   NZ_AP018400
Coordinates   583976..584680 (+) Length   234 a.a.
NCBI ID   WP_120171458.1    Uniprot ID   A0A2Z5TP69
Organism   Streptococcus ruminantium strain GUT-187     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 578976..589680
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SR187_RS02910 (SR187_2960) - 580789..581448 (-) 660 WP_120171455.1 amino acid ABC transporter permease -
  SR187_RS02915 (SR187_2965) - 581461..582159 (-) 699 WP_120171456.1 amino acid ABC transporter permease -
  SR187_RS02920 (SR187_2970) - 582174..583010 (-) 837 WP_120171457.1 transporter substrate-binding domain-containing protein -
  SR187_RS02925 (SR187_2975) - 583020..583781 (-) 762 WP_024532083.1 amino acid ABC transporter ATP-binding protein -
  SR187_RS02930 (SR187_2980) micA 583976..584680 (+) 705 WP_120171458.1 response regulator YycF Regulator
  SR187_RS02935 (SR187_2985) micB 584673..586022 (+) 1350 WP_024532081.1 cell wall metabolism sensor histidine kinase VicK Regulator
  SR187_RS02940 (SR187_2990) vicX 586029..586832 (+) 804 WP_024532080.1 MBL fold metallo-hydrolase Regulator
  SR187_RS02945 (SR187_2995) pbp2b 587055..589130 (+) 2076 WP_024532079.1 penicillin-binding protein PBP2B -

Sequence

Protein


Download         Length: 234 a.a.        Molecular weight: 26830.85 Da        Isoelectric Point: 5.2517

>NTDB_id=69442 SR187_RS02930 WP_120171458.1 583976..584680(+) (micA) [Streptococcus ruminantium strain GUT-187]
MKKILIVDDEKPISDIIKFNMTREGYEVVTAFDGREALETFEKEFPDVVILDVMLPELDGLEVARTIRKTSNVPILMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSELTETQVNLSSTSTSELVIGDLVILPDAFVAKKHGRELELT
HREFELLHHLAKHLGQVMTREHLLETVWGYDYFGDVRTVDVTIRRLREKIEDTPSRPEYILTRRGVGYFIKGNV

Nucleotide


Download         Length: 705 bp        

>NTDB_id=69442 SR187_RS02930 WP_120171458.1 583976..584680(+) (micA) [Streptococcus ruminantium strain GUT-187]
ATGAAAAAAATACTAATTGTAGATGATGAAAAACCAATCTCAGATATTATCAAATTTAATATGACCCGTGAAGGATATGA
AGTAGTGACAGCTTTTGACGGTCGTGAAGCACTGGAGACATTTGAGAAGGAATTTCCAGATGTTGTTATTTTGGATGTGA
TGTTGCCGGAGTTAGATGGACTAGAAGTGGCTCGAACAATCCGCAAGACTAGCAATGTTCCTATACTAATGCTATCAGCT
AAAGATAGCGAGTTTGATAAGGTTATCGGTCTTGAACTTGGTGCGGATGACTATGTGACAAAGCCCTTCTCTAATCGTGA
ATTACAGGCGCGTGTCAAGGCTCTTCTTCGTCGCAGTGAATTGACAGAAACGCAAGTTAATCTTTCTTCCACAAGTACCT
CAGAGTTAGTTATTGGGGACTTAGTTATCTTGCCAGATGCTTTTGTGGCTAAAAAACATGGTAGGGAATTGGAGTTGACT
CATCGTGAGTTCGAATTGCTTCATCATCTAGCTAAGCATTTGGGTCAGGTGATGACTCGCGAGCATTTGCTGGAAACTGT
GTGGGGCTACGATTATTTTGGTGATGTTCGTACAGTGGATGTGACCATTCGCCGTCTGCGGGAGAAGATTGAAGATACGC
CAAGCAGACCTGAGTACATCCTGACCCGTCGAGGTGTAGGATATTTTATAAAGGGAAATGTTTAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(154-229)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A2Z5TP69

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  micA Streptococcus pneumoniae Cp1015

80.769

100

0.808
  vicR Streptococcus mutans UA159

79.399

99.573

0.791
  covR Streptococcus salivarius strain HSISS4

44.156

98.718

0.436
  covR Lactococcus lactis subsp. lactis strain DGCC12653

43.478

98.291

0.427
  scnR Streptococcus mutans UA159

38.075

100

0.389

Multiple sequence alignment