Detailed information    

insolico Bioinformatically predicted

Overview

Name   comB   Type   Regulator
Locus tag   SR187_RS00355 Genome accession   NZ_AP018400
Coordinates   55654..57024 (+) Length   456 a.a.
NCBI ID   WP_323131747.1    Uniprot ID   A0A2Z5TTG2
Organism   Streptococcus ruminantium strain GUT-187     
Function   transport of ComC (predicted from homology)   
Competence regulation

Genomic Context

Location: 50654..62024
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SR187_RS09875 (SR187_0315) - 50678..50821 (+) 144 WP_155962526.1 hypothetical protein -
  SR187_RS00320 (SR187_0320) - 50874..51062 (+) 189 WP_024533071.1 class IIb bacteriocin, lactobin A/cerein 7B family -
  SR187_RS00325 (SR187_0330) - 51272..51454 (+) 183 WP_024533150.1 class IIb bacteriocin, lactobin A/cerein 7B family -
  SR187_RS00330 (SR187_0335) - 51538..51726 (+) 189 WP_120171169.1 class IIb bacteriocin, lactobin A/cerein 7B family -
  SR187_RS00335 (SR187_0345) - 51936..52130 (+) 195 WP_024533168.1 class IIb bacteriocin, lactobin A/cerein 7B family -
  SR187_RS00340 (SR187_0350) - 52336..52491 (+) 156 WP_024533167.1 class IIb bacteriocin, lactobin A/cerein 7B family -
  SR187_RS00345 (SR187_0355) - 52546..52737 (+) 192 WP_120171171.1 hypothetical protein -
  SR187_RS09880 (SR187_0365) - 53003..53149 (+) 147 WP_155962530.1 hypothetical protein -
  SR187_RS00350 (SR187_0370) comA 53495..55648 (+) 2154 WP_120171173.1 peptide cleavage/export ABC transporter ComA Regulator
  SR187_RS00355 (SR187_0375) comB 55654..57024 (+) 1371 WP_323131747.1 bacteriocin secretion accessory protein Regulator
  SR187_RS00360 (SR187_0380) ruvB 57453..58451 (+) 999 WP_024532316.1 Holliday junction branch migration DNA helicase RuvB -
  SR187_RS00365 (SR187_0385) - 58623..59246 (+) 624 WP_120172445.1 HAD-IA family hydrolase -
  SR187_RS00370 (SR187_0390) comR 59349..60251 (+) 903 WP_120171177.1 helix-turn-helix domain-containing protein Regulator
  SR187_RS00375 (SR187_0395) - 60453..61682 (+) 1230 WP_120171179.1 folylpolyglutamate synthase/dihydrofolate synthase family protein -

Sequence

Protein


Download         Length: 456 a.a.        Molecular weight: 50573.21 Da        Isoelectric Point: 5.7393

>NTDB_id=69419 SR187_RS00355 WP_323131747.1 55654..57024(+) (comB) [Streptococcus ruminantium strain GUT-187]
MMEHQLLESGEFYHRRYHNAASRVILPSFALLVFLMMFAFFAKKELTVVTRATVEPLHVLSKIQSTSNNPIKMNYLKENQ
EVAVGDVLVEYQSSSEQIQEEGIKKKITLLKEQLSQLELLKKSLESGENQFPQEDKYGYSQTFVDYRNKLLTLESNVEQQ
NTTIAAQNAAISQSQTELGNIVKTSQKALSDYKNLRMAIQSDAEISEDNAGYSLYVGYTTQLSQVTGIAEKTTLKQQMLT
QVDNQISQLENQLATYRVQYAGAGAQQAYATNLDSQSASLKSQYLTKVAQEWTSLSSQLGELEGTLGLQENMRAKTKIVA
NQAGIIHLNSEVEGASMIAEGTIIAHIYPSLAEIKKVKVTAYVSSKDVASLSEGDVIHFSAQASQAGQIRLTSTITSIAT
SATKTEAGNFFKIEAEADLSKAFAEKIRYGLEGKFVVITGEKTYFQYIVDEFLGKK

Nucleotide


Download         Length: 1371 bp        

>NTDB_id=69419 SR187_RS00355 WP_323131747.1 55654..57024(+) (comB) [Streptococcus ruminantium strain GUT-187]
ATGATGGAACATCAGCTATTAGAGAGTGGGGAATTTTACCATCGGCGTTATCATAATGCGGCAAGTAGAGTTATATTGCC
AAGTTTTGCTTTATTAGTCTTTTTGATGATGTTTGCCTTCTTTGCTAAGAAAGAACTGACGGTAGTGACTCGAGCAACTG
TTGAGCCACTTCATGTTTTATCCAAAATTCAATCCACAAGCAACAATCCTATTAAGATGAATTATTTGAAAGAAAATCAG
GAAGTTGCTGTGGGTGATGTTTTGGTTGAATATCAGTCTTCCAGTGAGCAGATTCAAGAAGAAGGTATTAAGAAAAAAAT
TACTCTGTTAAAGGAGCAATTATCTCAGCTTGAACTGTTGAAAAAGAGTTTAGAATCGGGAGAAAACCAGTTTCCTCAAG
AGGATAAGTATGGTTATTCACAAACCTTTGTTGATTATCGAAATAAATTATTGACATTGGAGAGCAATGTAGAGCAGCAG
AATACCACGATTGCTGCTCAGAATGCAGCTATTAGTCAATCGCAGACGGAATTAGGTAATATAGTCAAAACCAGTCAAAA
GGCATTGTCAGATTATAAGAATCTCAGAATGGCCATTCAATCTGACGCTGAAATTTCTGAGGATAATGCAGGTTATTCAC
TCTATGTGGGATATACAACTCAATTATCTCAAGTAACTGGTATAGCTGAAAAAACAACTCTTAAACAACAGATGTTAACG
CAGGTAGATAACCAAATTAGTCAATTAGAAAATCAGTTGGCTACTTATCGGGTACAGTATGCTGGGGCGGGAGCTCAACA
AGCCTATGCCACTAATTTAGATAGTCAGTCTGCATCGCTCAAATCCCAATATTTGACCAAGGTCGCCCAAGAGTGGACTT
CTCTATCAAGTCAATTAGGTGAACTTGAAGGGACATTGGGGTTACAAGAAAATATGAGAGCTAAGACAAAGATTGTAGCC
AATCAAGCAGGAATTATTCATCTAAATAGTGAAGTTGAGGGAGCATCTATGATTGCAGAAGGTACGATCATTGCTCACAT
TTATCCGAGTTTGGCTGAGATTAAAAAGGTAAAAGTTACCGCCTATGTATCCTCGAAAGATGTTGCCAGCCTGTCTGAGG
GAGATGTGATTCATTTTTCTGCTCAAGCTAGTCAAGCAGGACAGATTCGCCTGACTTCTACCATCACTTCTATTGCAACC
AGTGCGACCAAGACAGAAGCAGGAAATTTCTTTAAGATTGAAGCGGAGGCAGACTTATCAAAAGCATTTGCTGAGAAAAT
ACGGTATGGATTAGAAGGGAAATTTGTGGTAATTACAGGAGAGAAGACTTATTTTCAGTATATTGTAGATGAATTTTTAG
GGAAAAAATAA

Domains

Predicted by InterproScan.

HlyD family secretion protein (HlyD_3)

(318-420)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A2Z5TTG2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comB Streptococcus gordonii str. Challis substr. CH1

51.876

99.342

0.515
  comB Streptococcus pneumoniae Rx1

49.89

99.781

0.498
  comB Streptococcus pneumoniae D39

49.89

99.781

0.498
  comB Streptococcus pneumoniae R6

49.89

99.781

0.498
  comB Streptococcus pneumoniae TIGR4

49.67

99.781

0.496
  comB Streptococcus mitis SK321

49.67

99.781

0.496
  comB Streptococcus mitis NCTC 12261

49.231

99.781

0.491

Multiple sequence alignment