Detailed information NTG0692934

Bioinformatically predicted

Overview

• Name: comEA/celA/cilE
• Type: Machinery gene
• Locus tag: M9H69_RS06350
• Genome accession: NZ_CP097843
• Coordinates: 1230625..1231275 (-)
• Length: 216 a.a.
• NCBI ID: WP_250315113.1
• Uniprot ID: -
• Organism: Streptococcus oralis strain HP01
• Function: dsDNA binding to the cell surface (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1225625..1236275

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
M9H69_RS06325 (M9H69_06325)	-	1226568..1226948 (-)	381	WP_000157148.1	VOC family protein	-
M9H69_RS06330 (M9H69_06330)	rplT	1227007..1227366 (-)	360	WP_000124834.1	50S ribosomal protein L20	-
M9H69_RS06335 (M9H69_06335)	rpmI	1227418..1227618 (-)	201	WP_001125942.1	50S ribosomal protein L35	-
M9H69_RS06340 (M9H69_06340)	infC	1227651..1228181 (-)	531	WP_000848184.1	translation initiation factor IF-3	-
M9H69_RS06345 (M9H69_06345)	comEC/celB	1228401..1230641 (-)	2241	WP_250315111.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
M9H69_RS06350 (M9H69_06350)	comEA/celA/cilE	1230625..1231275 (-)	651	WP_250315113.1	helix-hairpin-helix domain-containing protein	Machinery gene
M9H69_RS06355 (M9H69_06355)	-	1231342..1231911 (-)	570	WP_084875437.1	GNAT family N-acetyltransferase	-
M9H69_RS06360 (M9H69_06360)	ald	1232088..1233200 (+)	1113	WP_250315115.1	alanine dehydrogenase	-
M9H69_RS06365 (M9H69_06365)	-	1233258..1234244 (-)	987	WP_250315116.1	PhoH family protein	-
M9H69_RS06370 (M9H69_06370)	-	1234325..1234540 (-)	216	WP_009066924.1	YozE family protein	-
M9H69_RS06375 (M9H69_06375)	-	1234564..1235142 (-)	579	WP_250315118.1	GrpB family protein	-
M9H69_RS06380 (M9H69_06380)	cvfB	1235154..1236008 (-)	855	WP_250315119.1	RNA-binding virulence regulatory protein CvfB	-

Sequence

Protein

• Length: 216 a.a.
• Molecular weight: 23093.28 Da
• Isoelectric Point: 5.9284

>NTDB_id=692934 M9H69_RS06350 WP_250315113.1 1230625..1231275(-) (comEA/celA/cilE) [Streptococcus oralis strain HP01]
MEAIIEKIKEYKIIVICAGLGLALGGFLLLKPSSQTPAKETNLQVEVAAVSKDSSSEKEVKKEEKEESPEQDLITVDVKG
AVKSSGIYDLPVGSRVHDAVQKAGGLTEEADSKSLNLAQKVSDEALVYVPTKGEEVASQQAASGTTPSSSKEKKVNLNKA
SLEELKQVKGLGGKRAQDIIDHREANGKFKSVDELKKVSGIGAKTIEKLKDYVTVD

Nucleotide

• Length: 651 bp

>NTDB_id=692934 M9H69_RS06350 WP_250315113.1 1230625..1231275(-) (comEA/celA/cilE) [Streptococcus oralis strain HP01]
ATGGAAGCAATTATCGAGAAAATCAAAGAGTATAAAATCATTGTCATTTGTGCTGGTTTAGGTTTGGCTTTGGGCGGATT
TCTCCTGCTAAAGCCAAGCTCCCAAACTCCCGCAAAGGAGACTAATCTACAGGTTGAAGTTGCCGCTGTTTCAAAGGATT
CATCTTCTGAAAAAGAAGTAAAGAAGGAAGAAAAGGAAGAGTCTCCTGAACAAGATTTGATTACAGTAGATGTCAAAGGT
GCTGTTAAATCTTCAGGAATTTATGATTTGCCAGTAGGTAGTCGTGTTCATGATGCCGTTCAGAAGGCGGGTGGCTTGAC
AGAAGAAGCAGACAGTAAGTCGCTCAATCTCGCTCAGAAAGTCAGTGACGAGGCTCTTGTCTATGTTCCAACTAAGGGAG
AAGAAGTAGCTAGTCAGCAGGCTGCCTCTGGAACGACTCCTTCGTCAAGTAAAGAAAAGAAGGTCAACCTCAATAAAGCT
AGTCTGGAAGAACTCAAGCAGGTCAAAGGCTTGGGAGGAAAACGAGCTCAGGATATTATCGACCATCGCGAGGCAAATGG
GAAATTCAAGTCGGTAGATGAATTAAAGAAAGTATCTGGCATTGGCGCTAAGACCATAGAAAAGCTAAAAGATTATGTTA
CAGTGGATTAA

Domains

Predicted by InterproScan.

• SLBB domain (SLBB) (76-126)

• Helix-hairpin-helix motif (HHH_3) (151-214)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEA/celA/cilE	Streptococcus mitis NCTC 12261	90.278	100	0.903
comEA/celA/cilE	Streptococcus pneumoniae TIGR4	89.815	100	0.898
comEA/celA/cilE	Streptococcus pneumoniae R6	88.426	100	0.884
comEA/celA/cilE	Streptococcus pneumoniae D39	88.426	100	0.884
comEA/celA/cilE	Streptococcus pneumoniae Rx1	88.426	100	0.884
comEA/celA/cilE	Streptococcus mitis SK321	86.111	100	0.861
comEA	Lactococcus lactis subsp. cremoris KW2	41.441	100	0.426