Detailed information NTG0690336

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: M8286_RS04100
• Genome accession: NZ_CP097577
• Coordinates: 833616..834287 (+)
• Length: 223 a.a.
• NCBI ID: WP_009909965.1
• Uniprot ID: A0A075SH40
• Organism: Streptococcus suis strain 3112
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 828616..839287

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
M8286_RS04070 (M8286_04095)	pstC	828726..829643 (+)	918	WP_002937619.1	phosphate ABC transporter permease subunit PstC	-
M8286_RS04075 (M8286_04100)	pstA	829633..830520 (+)	888	WP_358639239.1	phosphate ABC transporter permease PstA	-
M8286_RS04080 (M8286_04105)	pstB	830545..831348 (+)	804	WP_275601566.1	phosphate ABC transporter ATP-binding protein PstB	-
M8286_RS04085 (M8286_04110)	pstB	831360..832118 (+)	759	WP_275601567.1	phosphate ABC transporter ATP-binding protein PstB	-
M8286_RS04090 (M8286_04115)	phoU	832147..832803 (+)	657	WP_002937611.1	phosphate signaling complex protein PhoU	-
M8286_RS04095 (M8286_04120)	-	832969..833415 (+)	447	WP_275601568.1	hypothetical protein	-
M8286_RS04100 (M8286_04125)	ciaR	833616..834287 (+)	672	WP_009909965.1	response regulator transcription factor	Regulator
M8286_RS04105 (M8286_04130)	ciaH	834280..835659 (+)	1380	WP_275601569.1	HAMP domain-containing sensor histidine kinase	Regulator
M8286_RS04110 (M8286_04135)	-	835760..836989 (+)	1230	WP_275601570.1	transglutaminase domain-containing protein	-
M8286_RS04115 (M8286_04140)	rpsT	837256..837504 (-)	249	WP_012027069.1	30S ribosomal protein S20	-
M8286_RS04120 (M8286_04145)	coaA	837563..838483 (-)	921	WP_002935283.1	type I pantothenate kinase	-
M8286_RS04125 (M8286_04150)	-	838592..839182 (+)	591	WP_014635990.1	class I SAM-dependent methyltransferase	-

Sequence

Protein

• Length: 223 a.a.
• Molecular weight: 25290.00 Da
• Isoelectric Point: 4.2183

>NTDB_id=690336 M8286_RS04100 WP_009909965.1 833616..834287(+) (ciaR) [Streptococcus suis strain 3112]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGEEGVYEAETGVYDLILLDLMLPEKDGFQVLKELREKGVTTPVLITTA
KESLEDKGHGFELGADDYLTKPFYLEELKMRIQALLKRAGKFNENTLTFGDVTVDLSTNMTMVNGEEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRIWGFDSDTTISVVEVYVSKIRKKLKGTTFGENLQTLRSVGYILKNA

Nucleotide

• Length: 672 bp

>NTDB_id=690336 M8286_RS04100 WP_009909965.1 833616..834287(+) (ciaR) [Streptococcus suis strain 3112]
ATGATTAAAATATTGTTAGTGGAAGATGATTTAAGTCTATCAAATTCTGTTTTCGATTTCTTAGATGATTTTGCGGATGT
TATGCAGGTTTTTGATGGTGAAGAGGGCGTTTATGAGGCGGAAACAGGCGTTTATGATTTGATTCTTTTGGATTTGATGT
TGCCTGAAAAAGATGGCTTCCAAGTTTTGAAAGAGTTACGTGAAAAAGGTGTTACGACACCTGTTCTGATTACAACAGCC
AAGGAAAGTCTAGAGGATAAAGGCCATGGTTTTGAATTGGGGGCTGATGACTACTTGACAAAACCGTTTTATTTAGAAGA
ATTGAAGATGCGAATTCAAGCTCTATTAAAACGAGCGGGTAAGTTTAATGAAAACACACTAACTTTTGGGGACGTGACCG
TTGACCTATCTACAAATATGACGATGGTAAATGGCGAAGAAGTTGAACTGCTAGGAAAAGAATTTGACCTACTAGTTTAT
TTCTTGCAAAACCAAAATGTTATTTTGCCAAAAACACAAATTTTTGACCGTATTTGGGGCTTTGACAGTGATACTACAAT
TTCAGTAGTAGAAGTATATGTTTCTAAAATTAGGAAAAAGTTGAAAGGAACGACTTTTGGGGAAAATCTTCAAACCCTGC
GTAGTGTCGGATACATTCTAAAAAATGCCTAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

3D structure

• AlphaFold DB: A0A075SH40

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus mutans UA159	90.135	100	0.901
ciaR	Streptococcus pneumoniae Rx1	88.341	100	0.883
ciaR	Streptococcus pneumoniae D39	88.341	100	0.883
ciaR	Streptococcus pneumoniae R6	88.341	100	0.883
ciaR	Streptococcus pneumoniae TIGR4	88.341	100	0.883
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.496	100	0.39
vicR	Streptococcus mutans UA159	35.47	100	0.372
covR	Streptococcus salivarius strain HSISS4	35.841	100	0.363